scholarly journals A case of early gastric adenocarcinoma associated with type A gastritis, treated by endoscopic submucosal dissection

2015 ◽  
Vol 87 (1) ◽  
pp. 112-113
Author(s):  
Takahito Minaguchi ◽  
Naoto Yoshitake ◽  
Hitoshi Kino ◽  
Yoshihito Kaneko ◽  
Masakazu Nakano ◽  
...  
Keyword(s):  
Endoscopic Submucosal Dissection ◽  
Gastric Adenocarcinoma ◽  
Type A ◽  
Type A Gastritis ◽  
Submucosal Dissection

Histopathologic Change of a Case of Gastric Oxyntic Neoplasm (Gastric Adenocarcinoma of Fundic Gland Mucosa Type) Through 5 Years With Concurrent Other Oxyntic Gland Lesions

2020 ◽  
pp. 106689692096257
Author(s):  
Yoko Sato ◽  
Taiki Sato ◽  
Jun Matsushima ◽  
Akiko Fujii ◽  
Yuko Ono ◽  
...  
Keyword(s):  
Endoscopic Submucosal Dissection ◽  
Gastric Adenocarcinoma ◽  
Chief Cell ◽  
Fundic Gland ◽  
Submucosal Dissection ◽  
Epithelial Neoplasms ◽  
Oxyntic Gland ◽  
Gland Type ◽  
Histological Progression

Some gastric epithelial neoplasms show predominant chief cell differentiation (oxyntic gland neoplasms), in which the entity of “gastric adenocarcinoma of fundic gland type” was firstly designated, whereas a possible more aggressive subgroup “gastric adenocarcinoma of fundic gland mucosa type” (GA-FGM) was subsequently proposed. However, the histopathologic progression mode of these neoplasms has not been sufficiently reported. In this article, we describe a case of GA-FGM in which we could observe its progression during 5 years. The tumor was removed by endoscopic submucosal dissection 5 years after the first biopsy, which had already shown a feature of oxyntic gland neoplasm. During the follow-up period, the endoscopy revealed little change in the tumor appearance. However, the histology of endoscopic submucosal dissection showed submucosal extension with its histological progression. Besides, other oxyntic gland neoplasms of the stomach were observed metachronously or synchronously, giving an implication about a common pathogenetic basis of these lesions.

scholarly journals Gastric adenocarcinoma of the fundic gland type: clinicopathological features of eight patients treated with endoscopic submucosal dissection

2020 ◽  
Author(s):  
Chengfang Li ◽  
Xinglong Wu ◽  
Shuang Yang ◽  
Xiaorong Yang ◽  
Jin Yao ◽  
...  
Keyword(s):  
Endoscopic Submucosal Dissection ◽  
Gastric Adenocarcinoma ◽  
Narrow Band Imaging ◽  
Clinicopathological Features ◽  
World Health ◽  
Low Grade ◽  
Fundic Gland ◽  
Pepsinogen I ◽  
Submucosal Dissection ◽  
Gland Type

Abstract BackgroundGastric adenocarcinoma of the fundic gland type (GA-FG) has been added to the 2019 edition of the World Health Organization’s list of digestive system-associated cancers. This lesion differentiates toward the fundic gland and mostly involves chief cell-predominant differentiation with low-grade cytology. Clinicians and pathologists are still unaware of this rare disease; consequently, some cases are incorrectly diagnosed. This study aimed to investigate the clinicopathological features of GA-FG using retrospective analyses of endoscopic and pathological findings. Materials and methodsSamples were collected from patients diagnosed with GA-FG. The clinical courses of all patients were monitored prospectively and reviewed retrospectively. Available clinical information, endoscopic features, pathological appearance, and follow-up data were assessed. Immunohistochemistry [mucin (MUC) 2, MUC5, MUC6, P53, CDX2, Ki67, SYN, CD56, CGA, β-catenin, and pepsinogen-I] was examined using Envision two-step method.ResultsEight cases of endoscopic submucosal dissection (ESD) were obtained from our institution. Patient age ranged from 48-80 years (mean, 65 years). Some patients were on acid-suppressing medication. Most lesions were located in the upper third (n = 7) and one was in the middle third of the stomach. Six lesions were of the superficial flat type, whereas two were of the superficial elevated type. Narrow-band imaging using magnifying endoscopy showed irregular microvascular patterns (MVPs) in four cases and regular MVPs in the remaining cases. All lesions were primarily solitary and ~6 mm in diameter (largest, 12 mm). All tumors were localized in the mucosal layer with six cases of invasion into the submucosal layer. Well-formed glands of chief cells were predominant. Tumor cells were positive for pepsinogen-I, MUC6, SYN, and CD56. Lymphatic and vascular infiltration and metastatic and recurrent disease were not observed in any case.CONCLUSIONGA-FG, a well-differentiated adenocarcinoma with mild atypia, can be completely removed using ESD, with a favorable prognosis in patients.

scholarly journals Gastric adenocarcinoma of the fundic gland type: clinicopathological features of eight patients treated with endoscopic submucosal dissection

2020 ◽  
Author(s):  
Chengfang Li ◽  
Xinglong Wu ◽  
Shuang Yang ◽  
Xiaorong Yang ◽  
Jin Yao ◽  
...  
Keyword(s):  
Endoscopic Submucosal Dissection ◽  
Gastric Adenocarcinoma ◽  
Clinicopathological Features ◽  
World Health ◽  
Low Grade ◽  
Main Body ◽  
Fundic Gland ◽  
Pepsinogen I ◽  
Submucosal Dissection ◽  
Gland Type

Abstract Background Gastric adenocarcinoma of the fundic gland type (GA-FG) has been added to the 2019 edition of the World Health Organization’s list of digestive system-associated cancers. This lesion differentiates toward the fundic gland and mostly involves chief cell-predominant differentiation with low-grade cytology. Clinicians and pathologists are still unaware of this rare disease; consequently, some cases are incorrectly diagnosed. This study aimed to investigate the clinicopathological features of GA-FG using retrospective analyses of endoscopic and pathological findings. Materials and methods Samples were collected from patients diagnosed with GA-FG. The clinical courses of all patients were monitored prospectively and reviewed retrospectively. Available clinical information, endoscopic features, pathological appearance, and follow-up data were assessed. Immunohistochemistry [mucin (MUC) 2, MUC5, MUC6, P53, CDX2, Ki67, SYN, CD56, CGA, β-catenin, and pepsinogen-I] was examined using Envision two-step method.Results Eight cases of endoscopic submucosal dissection (ESD) were obtained from our institution. Patient age ranged from 48-80 years (mean, 65 years). Some patients were on acid-suppressing medication. Most lesions were located in the upper third (n = 7) and one was in the middle third of the stomach. Six lesions were of the superficial flat type, whereas two were of the superficial elevated type. Narrow-band imaging using magnifying endoscopy showed irregular microvascular patterns (MVPs) in four cases and regular MVPs in the remaining cases. All lesions were primarily solitary and ~6 mm in diameter (largest, 12 mm). The main body of the tumors were localized in the mucosal layer, of which six cases invade into the submucosal layer. Well-formed glands of chief cells were predominant. Tumor cells were positive for pepsinogen-I, MUC6, SYN, and CD56. Lymphatic and vascular infiltration and metastatic and recurrent disease were not observed in any case.Conclusion GA-FG, a well-differentiated adenocarcinoma with mild atypia, can be completely removed using ESD, with a favorable prognosis in patients.

scholarly journals Sa1222 VALIDATION OF EXPANDED ENDOSCOPIC SUBMUCOSAL DISSECTION CRITERIA FOR TREATMENT OF EARLY GASTRIC ADENOCARCINOMA IN A WESTERN CENTER

2018 ◽  
Vol 87 (6) ◽  
pp. AB170-AB171
Author(s):  
Fernanda C. Pessorrusso ◽  
Aloisio Felipe-Silva ◽  
Carlos E. Jacob ◽  
Marcus F. Ramos ◽  
Bruno Zilberstein ◽  
...  
Keyword(s):  
Endoscopic Submucosal Dissection ◽  
Gastric Adenocarcinoma ◽  
Submucosal Dissection
Sign in / Sign up

Export Citation Format

Share Document