scholarly journals A Case of Serous cystic neoplasm (SCN) with back pain

2008 ◽  
Vol 72 (2) ◽  
pp. 114-115
Author(s):  
Hiroyuki Ariga ◽  
Junya Kashimura ◽  
Toshihiro Minakawa ◽  
Kyouko Minakawa ◽  
Futoshi Hirai ◽  
...  
Author(s):  
Chengwei Shao ◽  
Xiaochen Feng ◽  
Jieyu Yu ◽  
Yinghao Meng ◽  
Fang Liu ◽  
...  

2016 ◽  
Vol 77 (6) ◽  
pp. 1551-1556
Author(s):  
Yu YOSHIDA ◽  
Makoto MURAKAMI ◽  
Takanori GOI ◽  
Kanji KATAYAMA ◽  
Yoshiyuki IMAMURA ◽  
...  

Pancreas ◽  
2012 ◽  
Vol 41 (3) ◽  
pp. 380-387 ◽  
Author(s):  
Wataru Kimura ◽  
Toshiyuki Moriya ◽  
Keiji Hanada ◽  
Hideki Abe ◽  
Akio Yanagisawa ◽  
...  

Suizo ◽  
2018 ◽  
Vol 33 (2) ◽  
pp. 131-139 ◽  
Author(s):  
Wataru KIMURA ◽  
Toshihiro WATANABE

2021 ◽  
Vol 54 (7) ◽  
pp. 471-479
Author(s):  
Takashi Shigeno ◽  
Koji Ito ◽  
Yoshiteru Ohata ◽  
Hiroki Ueda ◽  
Toshiro Tanioka ◽  
...  

2020 ◽  
Vol 4 (2) ◽  
pp. e201900503
Author(s):  
Wen-Cheng Chung ◽  
Lavanya Challagundla ◽  
Yunyun Zhou ◽  
Min Li ◽  
Azeddine Atfi ◽  
...  

Notch signaling exerts both oncogenic and tumor-suppressive functions in the pancreas. In this study, deletion of Jag1 in conjunction with oncogenic KrasG12D expression in the mouse pancreas induced rapid development of acinar-to-ductal metaplasia and early stage pancreatic intraepithelial neoplasm; however, culminating in cystic neoplasms rather than ductal adenocarcinoma. Most cystic lesions in these mice were reminiscent of serous cystic neoplasm, and the rest resembled intraductal papillary mucinous neoplasm. Jag1 expression was lost or decreased in cystic lesions but retained in adenocarcinoma in these mice, so was the expression of Sox9. In pancreatic cancer patients, JAG1 expression is higher in cancerous tissue, and high JAG1 is associated with poor overall survival. Expression of SOX9 is correlated with JAG1, and high SOX9 is also associated with poor survival. Mechanistically, Jag1 regulates expression of Lkb1, a tumor suppressor involved in the development of pancreatic cystic neoplasm. Collectively, Jag1 can act as a tumor suppressor in the pancreas by delaying precursor lesions, whereas loss of Jag1 promoted a phenotypic switch from malignant carcinoma to benign cystic lesions.


Pancreatology ◽  
2017 ◽  
Vol 17 (5) ◽  
pp. S16
Author(s):  
M.A. Casi Villarroya ◽  
D. Ruiz-Clavijo García ◽  
B. Gonzálezde la Higuera Carnicer ◽  
C. Marra-López Valenciano ◽  
S. López López ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document