scholarly journals A case of metachronous early gastric cancer was diagnosed 4years after eradication of H. pylori infection

2005 ◽  
Vol 66 (2) ◽  
pp. 54-55
Author(s):  
Mikinori Kataoka ◽  
Takashi Kawai ◽  
Kouhei Kawakami ◽  
Satoru Taira ◽  
Takao Itoi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
H Pylori

Sa1298 – Gastric Xanthoma is a Useful Predictor for Early Gastric Cancer Detected After H. Pylori Eradication

2019 ◽  
Vol 156 (6) ◽  
pp. S-310
Author(s):  
Narihiro Shibukawa ◽  
Shohei Ouchi ◽  
Shuji Wakamatsu ◽  
Yuhei Wakahara ◽  
Akira Kaneko
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
H Pylori

H. Pylori eradication for the prevention of metachronous gastric cancer after endoscopic resection of early gastric cancer

2001 ◽  
Vol 120 (5) ◽  
pp. A744
Author(s):  
Mototsugu Kato ◽  
Kaku Hokari ◽  
Jun Ishizuka ◽  
Takuji Mizushima ◽  
Yoshito Komatsu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Endoscopic Resection ◽  
Metachronous Gastric Cancer ◽  
H Pylori

scholarly journals Evidence of origin with epigenetic change of metachronous lesions in early gastric cancer after endoscopic submucosal dissection

2021 ◽  
Author(s):  
Yo Kubota ◽  
Satoshi Tanabe ◽  
Mizutomo Azuma ◽  
Kazue Horio ◽  
Yoshiki Fujiyama ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Methylation ◽  
Early Gastric Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Operating Characteristic ◽  
Cysteine Dioxygenase ◽  
Epigenetic Change ◽  
Submucosal Dissection ◽  
H Pylori

Abstract Early gastric cancer (EGC) with metachronous lesions developing on scars after endoscopic submucosal dissection (ESD) is extremely rare and hard to treat. We evaluated whether DNA methylation of the cancer-specific methylation gene, cysteine dioxygenase type 1 (CDO1), would predict such lesions. CDO1 methylation (TaqMeth) values were compared between 11 patients with metachronous lesions developing on scars after ESD (M group) identified from 2,055 patients (0.5%) and 33 patients with EGC with no confirmed evidence of metachronous lesions at > 3 years after ESD (solitary [S] group). To assess Helicobacter pylori influence, 11 H. pylori-negative EGC patients (N group) were also analyzed. Each ESD specimen was measured at the tumor (T) and 4-points separated tumor-adjacent noncancerous mucosa (TAM). TaqMeth values for T were significantly higher than TAM (S + M) (P = 0.0019) and TAM (N) (P < 0.0001). Moreover, TAM (M) had significantly higher TaqMeth values than TAM (S) (P < 0.0001) suggesting that TAM (M) exhibited CDO1 hypermethylation similar to T (P = 0.5713). Additionally, TaqMeth values for TAM (S) were significantly higher than TAM (N) (P < 0.0001). The receiver operating characteristic for discriminating the highest TaqMeth values separated TAMs (M) from those of TAMs (S) was 0.81. CDO1 hypermethylation promisingly predicted EGC with metachronous lesions developing on scars after ESD.

scholarly journals The effect of Helicobacter pylori eradication on prognosis of postoperative early gastric cancer: a multicenter study

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Liang Wang ◽  
Jinfeng Wang ◽  
Sha Li ◽  
Fei Bai ◽  
Hailong Xie ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Overall Survival ◽  
Helicobacter Pylori ◽  
Early Gastric Cancer ◽  
Positive Node ◽  
Node Metastasis ◽  
Undifferentiated Type ◽  
Independent Risk Factors ◽  
H Pylori

Abstract Objective To investigate the effect of Helicobacter pylori (H. pylori) eradication on the prognosis of postoperative early gastric cancer (EGC). Methods This is a retrospective study based on data from 6 hospitals. We identified 429 patients with EGC who underwent curative gastrectomy from January 2010 to December 2016. All of the patients were tested for H. pylori. Patients were divided into two groups, the successful H. pylori eradication group (group A, 268 patients) and the non-H. pylori eradication group (group B, 161 patients), for calculating the disease-free survival (DFS) and overall survival (OS) of each group. Result Positive node metastasis (hazard ratio (HR), 3.13; 95% confidence interval (CI), 1.84–5.32; P < 0.001), undifferentiated type (HR, 2.54; 95% CI, 1.51–4.28; P < 0.001), and non-H. pylori eradication (HR, 1.73; 95% CI, 1.08–2.77; P = 0.023) were statistically significantly independent risk factors of recurrence. Patient’s age ≥60 years old (HR, 3.32; 95% CI, 2.00–5.53; P < 0.001), positive node metastasis (HR, 3.71; 95% CI, 2.25–6.12; P < 0.001), undifferentiated type (HR, 3.06; 95% CI, 1.79–5.23; P < 0.001), and non-H. pylori eradication (HR, 1.83; 95% CI, 1.11–3.02; P = 0.018) were statistically significantly independent risk factors of overall survival. Conclusion H. pylori eradication treatment could prevent the recurrence of postoperative EGC to prolong the overall survival of patients with EGC.

Abstract 542: CEACAM6 is upregulated by the H Pylori CAG-A oncoprotein, and is a candidate biomarker for the diagnosis of early gastric cancer

2015 ◽  
Author(s):  
Anand D. Jeyasekharan ◽  
Rony K. Roy ◽  
Michal M. Hoppe ◽  
Kar Tong Tan ◽  
Henry Yang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
H Pylori ◽  
Cag A

scholarly journals Helicobacter pylori Infection following Endoscopic Resection of Early Gastric Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Lan Li ◽  
Chaohui Yu
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Early Gastric Cancer ◽  
Endoscopic Resection ◽  
Precancerous Lesions ◽  
Cost Effective ◽  
Reduce Healthcare Cost ◽  
Metachronous Gastric Cancer ◽  
H Pylori ◽  
Meta Analyses

The role of Helicobacter pylori (H. pylori) infection in patients following endoscopic resection of early gastric cancer (EGC) remains unclear. This article presents a review of literature published in the past 15 years. H. pylori‐mediated persistent methylation levels are associated with the development of metachronous gastric cancer. The methylation of certain specific genes can be used to identify patients with a high risk of metachronous gastric cancer even after H. pylori eradication. H. pylori eradication after endoscopic resection should be performed as early as possible for eradication success and prevention of metachronous precancerous lesions. Although whether the eradication of H. pylori could prevent the development of metachronous cancer after endoscopic resection is controversial, several meta‐analyses concluded that H. pylori eradication could reduce the incidence of metachronous gastric cancer significantly. In addition, H. pylori eradication in gastric cancer survivors after endoscopic resection could reduce healthcare cost and save lives in a cost‐effective way. Taken together, H. pylori eradication after endoscopic resection of EGC is recommended as prevention for metachronous precancerous lesions and metachronous gastric cancer.

T2067 Prospective Analysis of Metachronous Early Gastric Cancer in High Risk Patients After H. pylori Eradication

2008 ◽  
Vol 134 (4) ◽  
pp. A-612
Author(s):  
Akiko Shiotani ◽  
Noriya Uedo ◽  
Tomoari Kamada ◽  
Hiroyasu Iishi ◽  
Masaharu Tatsuta ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Risk ◽  
Early Gastric Cancer ◽  
Prospective Analysis ◽  
High Risk Patients ◽  
Risk Patients ◽  
H Pylori

scholarly journals Gastric Xanthoma Associated with Gastric Cancer Development: An Updated Review

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Faycal Awaleh Moumin ◽  
Abdimajid Ahmed Mohamed ◽  
Abdirahman Ahmed Osman ◽  
Jianting Cai
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Chronic Gastritis ◽  
Incidental Finding ◽  
Predictive Marker ◽  
Cancer Development ◽  
Hyperplastic Polyps ◽  
Benign Lesions ◽  
H Pylori ◽  
Foamy Macrophages

Gastric xanthelasma (GX) is a rare tumor-like lesion customarily found as an incidental finding due to its asymptomatic appearance. Grossly, it is a well-marked yellow-white plaque created in the lamina propria by microscopic clusters of foamy macrophages. Xanthelasma is rarely correlated with gastric hyperplastic polyps; gastric xanthomas are rare benign lesions that appear to be associated with inflammation of the gastric mucosa. Etiopathogenesis is also unclear, but it has been suggested to be involved in chronic gastritis, infection with Helicobacter pylori (H. pylori), diabetes mellitus, and hyperlipidemia. The gastric xanthoma prevalence ranges from 0.23% to 7%. Orth first described the condition in 1887. It has been found that xanthelasmas are associated with chronic gastritis, gastrointestinal anastomosis, intestinal metaplasia, and H. pylori infection. These lesions predispose patients to gastric cancer conditions. Xanthoma (GX) was reported to be a predictive marker for early gastric cancer. However, the effectiveness of these scores and xanthoma (GX) as predictive markers for early gastric cancer detected after H. pylori eradication remains unknown.

scholarly journals Increased Reflux Esophagitis after Helicobacter pylori Eradication Therapy in Cases Undergoing Endoscopic Submucosal Dissection for Early Gastric Cancer

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1779
Author(s):  
Masaki Katsurahara ◽  
Ichiro Imoto ◽  
Yuhei Umeda ◽  
Hiroshi Miura ◽  
Junya Tsuboi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Early Gastric Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Reflux Esophagitis ◽  
Eradication Therapy ◽  
Submucosal Dissection ◽  
Before And After ◽  
H Pylori

Background: The role of Helicobacter pylori in the pathogenesis of reflux esophagitis is controversial. This study investigated the frequency of reflux esophagitis before and after H. pylori eradication in patients having endoscopic submucosal dissection for early gastric cancer. Methods: This study included 160 patients that fulfilled the study’s criteria. Endoscopy was performed before and after H. pylori eradication, and reflux esophagitis was evaluated during the follow-up period. Results: Seropositivity for H. pylori in patients with early gastric cancer was 68.8%, 101 of them received eradication therapy. During the follow-up period, the incidence of reflux esophagitis increased from 3.1% to 18.8% in the successful eradication group but no case of reflux esophagitis was observed in the failed eradication group. The univariate and multivariate analyses showed a significant correlation between successful H. pylori eradication rate and the development of reflux esophagitis. Conclusions: This study demonstrated that a successful H. pylori eradication therapy is a risk factor for newly developed reflux esophagitis in patients with endoscopic submucosal dissection for early gastric cancer.

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