scholarly journals Usefulness of cytologic examination using pancreatic duct lavage fluid for diagnosis of pancreatic ductal carcinoma -A novel examination developed for pancreatic ductal carcinoma-

2003 ◽  
Vol 62 (2) ◽  
pp. 55-59
Author(s):  
Tsunao Imamura ◽  
Hitoshi Yoshida ◽  
Katsuya Kitamura ◽  
Tatsurou Yanagawa ◽  
Takeshi Saito ◽  
...  
Keyword(s):  
Pancreatic Duct ◽  
Ductal Carcinoma ◽  
Lavage Fluid ◽  
Pancreatic Ductal Carcinoma ◽  
Cytologic Examination ◽  
Duct Lavage

Pancreatic duct lavage fluid can improve ERCP diagnostic accuracy in early pancreatic ductal carcinoma

Pancreatology ◽  
2016 ◽  
Vol 16 (4) ◽  
pp. S144
Author(s):  
Tsunao Imamura ◽  
Rikako Koyama ◽  
Yuko Koizumi ◽  
Tetsuo Tamura ◽  
Yuji Urasaki
Keyword(s):  
Diagnostic Accuracy ◽  
Pancreatic Duct ◽  
Ductal Carcinoma ◽  
Lavage Fluid ◽  
Pancreatic Ductal Carcinoma ◽  
Duct Lavage

EFFECTIVENESS OF CYTODIAGNOSIS WITH PANCREATIC DUCT LAVAGE FLUID FOR PANCREATIC DUCTAL CARCINOMA: NEW SAMPLING TECHNIQUE

2006 ◽  
Vol 18 (4) ◽  
pp. 303-307 ◽  
Author(s):  
Tsunao Imamura ◽  
Rie Takeshita ◽  
Rikako Koyama ◽  
Chikao Okuda ◽  
Kazuo Takeuchi ◽  
...  
Keyword(s):  
Pancreatic Duct ◽  
Ductal Carcinoma ◽  
Sampling Technique ◽  
Lavage Fluid ◽  
Pancreatic Ductal Carcinoma ◽  
Duct Lavage

Effectiveness of cytodiagnosis with pancreatic duct lavage fluid for pancreatic ductal cancer

Pancreatology ◽  
2016 ◽  
Vol 16 (4) ◽  
pp. S117
Author(s):  
Yoshitaka Nakai ◽  
Kiyonori Kusumoto ◽  
Takeharu Nakamura ◽  
Yoshio Itokawa
Keyword(s):  
Pancreatic Duct ◽  
Lavage Fluid ◽  
Ductal Cancer ◽  
Duct Lavage

scholarly journals Favorable Response After Gemcitabine-Radiotherapy for Invasive Pancreatic Intraductal Papillary Mucinous Neoplasm: A Case Report

2013 ◽  
Vol 98 (4) ◽  
pp. 340-345 ◽  
Author(s):  
Takanori Ochiai ◽  
Kimihiro Igari ◽  
Takaki Furuyama ◽  
Hiromitsu Ito ◽  
Yusuke Mitsunori ◽  
...  
Keyword(s):  
Pancreatic Duct ◽  
Intraductal Papillary Mucinous Neoplasm ◽  
Ductal Carcinoma ◽  
Total Pancreatectomy ◽  
Surgical Margin ◽  
Resected Specimen ◽  
Pancreatic Ductal Carcinoma ◽  
Positive Surgical Margin ◽  
Mucinous Neoplasm ◽  
Remnant Pancreas

Abstract The efficacy of chemoradiotherapy for invasive pancreatic ductal carcinoma derived from an intraductal papillary mucinous neoplasm (IPMN) has not been established. The subject of the present report was a 53-year-old man admitted for the treatment of IPMN. The tumor, located in the pancreatic body, was of the mixed type of IPMN, and it involved the branch duct, where it was 38 mm in diameter, and the main duct, where it was 6 mm in diameter. Distal pancreatectomy was performed and the postoperative course was uneventful; however, histopathologic diagnosis revealed invasive ductal carcinoma with a positive surgical margin in the pancreatic duct. Although total pancreatectomy was recommended, chemoradiotherapy (50.4-Gy irradiation and gemcitabine) was preferred by the patient. At 9-month follow up, computed tomography and magnetic resonance imaging showed a cystic mass at the surgical margin of the pancreas. Endoscopic ultrasonography showed a 44-mm cystic lesion with nodules in the remnant pancreas, on the basis of which he underwent total pancreatectomy. Pathologic examination of the resected specimen revealed absence of the epithelium at the surgical margin of the main pancreatic duct, and malignant cells were not detected.

scholarly journals Ca2+ Signaling and Its Potential Targeting in Pancreatic Ductal Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 3085
Author(s):  
Louay Bettaieb ◽  
Maxime Brulé ◽  
Axel Chomy ◽  
Mel Diedro ◽  
Malory Fruit ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Exocrine Pancreas ◽  
Ductal Carcinoma ◽  
Ductal Adenocarcinoma ◽  
Molecular Devices ◽  
Pancreatic Ductal Carcinoma ◽  
Aberrant Expression ◽  
Common Cause ◽  
Cancer Hallmarks ◽  
Cancer Mutations

Pancreatic cancer (PC) is a major cause of cancer-associated mortality in Western countries (and estimated to be the second cause of cancer deaths by 2030). The main form of PC is pancreatic adenocarcinoma, which is the fourth most common cause of cancer-related death, and this situation has remained virtually unchanged for several decades. Pancreatic ductal adenocarcinoma (PDAC) is inherently linked to the unique physiology and microenvironment of the exocrine pancreas, such as pH, mechanical stress, and hypoxia. Of them, calcium (Ca2+) signals, being pivotal molecular devices in sensing and integrating signals from the microenvironment, are emerging to be particularly relevant in cancer. Mutations or aberrant expression of key proteins that control Ca2+ levels can cause deregulation of Ca2+-dependent effectors that control signaling pathways determining the cells’ behavior in a way that promotes pathophysiological cancer hallmarks, such as enhanced proliferation, survival and invasion. So far, it is essentially unknown how the cancer-associated Ca2+ signaling is regulated within the characteristic landscape of PDAC. This work provides a complete overview of the Ca2+ signaling and its main players in PDAC. Special consideration is given to the Ca2+ signaling as a potential target in PDAC treatment and its role in drug resistance.

scholarly journals Pre-Operative Imaging and Pathological Diagnosis of Localized High-Grade Pancreatic Intra-Epithelial Neoplasia without Invasive Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 945
Author(s):  
Ryota Sagami ◽  
Kentaro Yamao ◽  
Jun Nakahodo ◽  
Ryuki Minami ◽  
Masakatsu Tsurusaki ◽  
...  
Keyword(s):  
Pancreatic Duct ◽  
Invasive Carcinoma ◽  
Current Knowledge ◽  
Precancerous Lesions ◽  
Ductal Adenocarcinoma ◽  
Pancreatic Ducts ◽  
High Grade ◽  
Cytologic Examination ◽  
Imaging Characteristics ◽  
Retention Cysts

Pancreatic ductal adenocarcinoma (PDAC) arises from precursor lesions, such as pancreatic intra-epithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN). The prognosis of high-grade precancerous lesions, including high-grade PanIN and high-grade IPMN, without invasive carcinoma is good, despite the overall poor prognosis of PDAC. High-grade PanIN, as a lesion preceding invasive PDAC, is therefore a primary target for intervention. However, detection of localized high-grade PanIN is difficult when using standard radiological approaches. Therefore, most studies of high-grade PanIN have been conducted using specimens that harbor invasive PDAC. Recently, imaging characteristics of high-grade PanIN have been revealed. Obstruction of the pancreatic duct due to high-grade PanIN may induce a loss of acinar cells replaced by fibrosis and lobular parenchymal atrophy. These changes and additional inflammation around the branch pancreatic ducts (BPDs) result in main pancreatic duct (MPD) stenosis, dilation, retention cysts (BPD dilation), focal pancreatic parenchymal atrophy, and/or hypoechoic changes around the MPD. These indirect imaging findings have become important clues for localized, high-grade PanIN detection. To obtain pre-operative histopathological confirmation of suspected cases, serial pancreatic-juice aspiration cytologic examination is effective. In this review, we outline current knowledge on imaging characteristics of high-grade PanIN.

scholarly journals Efficacy of contrast-enhanced harmonic endoscopic ultrasonography in the diagnosis of pancreatic ductal carcinoma

2016 ◽  
Vol 22 (3) ◽  
pp. 198 ◽  
Author(s):  
Toshiyuki Uekitani ◽  
Seiji Kaino ◽  
Hirofumi Harima ◽  
Shigeyuki Suenaga ◽  
Manabu Sen-yo ◽  
...  
Keyword(s):  
Endoscopic Ultrasonography ◽  
Ductal Carcinoma ◽  
Pancreatic Ductal Carcinoma ◽  
Contrast Enhanced

scholarly journals Cutaneous Malassezia: Commensal, Pathogen, or Protector?

2021 ◽  
Vol 10 ◽  
Author(s):  
Shree Harsha Vijaya Chandra ◽  
Ramasamy Srinivas ◽  
Thomas L. Dawson ◽  
John E. Common
Keyword(s):  
Rational Design ◽  
Health Knowledge ◽  
Ductal Carcinoma ◽  
Genetic Manipulation ◽  
Seborrheic Dermatitis ◽  
Treatment Options ◽  
Pancreatic Ductal Carcinoma ◽  
Skin Microbiome ◽  
Targeted Interventions ◽  
Host Microbe Interactions

The skin microbial community is a multifunctional ecosystem aiding prevention of infections from transient pathogens, maintenance of host immune homeostasis, and skin health. A better understanding of the complex milieu of microbe-microbe and host-microbe interactions will be required to define the ecosystem’s optimal function and enable rational design of microbiome targeted interventions. Malassezia, a fungal genus currently comprising 18 species and numerous functionally distinct strains, are lipid-dependent basidiomycetous yeasts and integral components of the skin microbiome. The high proportion of Malassezia in the skin microbiome makes understanding their role in healthy and diseased skin crucial to development of functional skin health knowledge and understanding of normal, healthy skin homeostasis. Over the last decade, new tools for Malassezia culture, detection, and genetic manipulation have revealed not only the ubiquity of Malassezia on skin but new pathogenic roles in seborrheic dermatitis, psoriasis, Crohn’s disease, and pancreatic ductal carcinoma. Application of these tools continues to peel back the layers of Malassezia/skin interactions, including clear examples of pathogenicity, commensalism, and potential protective or beneficial activities creating mutualism. Our increased understanding of host- and microbe-specific interactions should lead to identification of key factors that maintain skin in a state of healthy mutualism or, in turn, initiate pathogenic changes. These approaches are leading toward development of new therapeutic targets and treatment options. This review discusses recent developments that have expanded our understanding of Malassezia’s role in the skin microbiome, with a focus on its multiple roles in health and disease as commensal, pathogen, and protector.

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