scholarly journals A case report of multiple gastric cancer with positive-microsatellite instability and metachronous multiple cororectal cancer

2001 ◽  
Vol 59 (2) ◽  
pp. 84-85
Author(s):  
Takaaki Kobayashi ◽  
Takeshi Omura ◽  
Hiroaki Nozawa ◽  
Hiroyoshi Morita ◽  
Takayoshi Sekikawa ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Case Report ◽  
Microsatellite Instability ◽  
Multiple Gastric Cancer

scholarly journals Haploinsufficiency by minute MutL homolog 1 promoter DNA methylation may represent unique phenotypes of microsatellite instability-gastric carcinogenesis

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0260303
Author(s):  
Hiroki Harada ◽  
Yusuke Nie ◽  
Ippeita Araki ◽  
Takafumi Soeno ◽  
Motohiro Chuman ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Methylation ◽  
Microsatellite Instability ◽  
Methylation Status ◽  
Gastric Carcinogenesis ◽  
Primary Gastric Cancer ◽  
Promoter Dna Methylation ◽  
Mutl Homolog 1 ◽  
Multiple Gastric Cancer ◽  
Promoter Dna

Promoter DNA methylation of MutL homolog 1 (MLH1) is considered to play a causative role in microsatellite instability (MSI) carcinogenesis in primary gastric cancer, and a high MSI status is associated with treatment sensitivity to human cancers. Nevertheless, clinicopathological analysis is defective for MLH1 methylation status in a quantitative manner. We newly developed quantitative methylation specific PCR using a TaqMan probe and applied it to 138 patients with primary gastric cancer who underwent gastrectomy in addition to basic molecular features such as MSI, Epstein Barr virus, and other DNA methylation status. (1) In primary gastric cancer, median methylation value was 0.055, ranging from 0 to 124.3. First, MLH1 hypermethylation was strongly correlated with MSI-High/MSI-Low status and suppressed immunostaining (P < 0.0001). (2) The MLH1 hypermethylation was associated with advanced age (P = 0.0048), antral location (P = 0.0486), synchronous multiple gastric cancer (P = 0.0001), and differentiated histology (P = 0.028). (3) Log-rank plot analysis identified the most relevant cut-off value (0.23) to reflect gentle phenotypes in MLH1 hypermethylation cases (P = 0.0019), especially in advanced gastric cancer (P = 0.0132), which are designated as haploinsufficiency of MSI (MSI-haplo) phenotype in this study. (4) In synchronous multiple gastric cancer, MLH1 hypermethylation was not necessarily confirmed as field cancerization. (5) MSI-haplo defined by MLH1 methylation status represented distinct prognostic phenotype even after molecular classifications. MLH1 hypermethylation designated as MSI-haplo may represent unique prognostic phenotype during gastric carcinogenesis.

scholarly journals A CASE REPORT OF RESECTED SYNCHRONOUS DOUBLE CANCER WITH PANCREATIC CANCER AND MULTIPLE GASTRIC CANCER

1995 ◽  
Vol 56 (9) ◽  
pp. 1856-1861
Author(s):  
You KAWARADA ◽  
Ken KANAOKA ◽  
Kouhei TAKANO ◽  
Kazuaki HAZAMA ◽  
Tomozki TAKADA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Pancreatic Cancer ◽  
Case Report ◽  
Double Cancer ◽  
Multiple Gastric Cancer

scholarly journals Microsatellite instability in Gastric Cancer: Between lights and shadows

2021 ◽  
Vol 95 ◽  
pp. 102175
Author(s):  
Elisabetta Puliga ◽  
Simona Corso ◽  
Filippo Pietrantonio ◽  
Silvia Giordano
Keyword(s):  
Gastric Cancer ◽  
Microsatellite Instability

scholarly journals P44-4 A case report of four patients received ramucirumab monotherapy as second-line treatment for advanced gastric cancer

2021 ◽  
Vol 32 ◽  
pp. S353
Author(s):  
Kei Onodera ◽  
Akiko Ichiyanagi ◽  
Akari Ueno ◽  
Motohiro Tani ◽  
Shuji Sato ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Case Report ◽  
Advanced Gastric Cancer ◽  
Line Treatment ◽  
Second Line

scholarly journals Intratumoral pseudoaneurysm within a liver metastasis of gastric cancer: a case report

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Hiroki Ohara ◽  
Yuji Ishibashi ◽  
Shuntaro Yoshimura ◽  
Ryoto Yamazaki ◽  
Fumihiko Hatao ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Case Report ◽  
Liver Metastasis
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