Role of Exercise and Lung Function in Predicting Work Status in Cystic Fibrosis

2003 ◽  
Vol 167 (2) ◽  
pp. 150-157 ◽  
Author(s):  
Despina D. Frangolias ◽  
Caroline L. Holloway ◽  
Sverre Vedal ◽  
Pearce G. Wilcox
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Work Status

scholarly journals Risk factors for respiratory Aspergillus fumigatus in German Cystic Fibrosis patients and impact on lung function

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Uta Düesberg ◽  
Julia Wosniok ◽  
Lutz Naehrlich ◽  
Patience Eschenhagen ◽  
Carsten Schwarz
Keyword(s):  
Risk Factors ◽  
Cystic Fibrosis ◽  
Lung Function ◽  
Aspergillus Fumigatus ◽  
Age Groups ◽  
Antibiotic Use ◽  
Lower Lung ◽  
Lung Infections ◽  
The Impact

Abstract Airway inflammation and chronic lung infections in cystic fibrosis (CF) patients are mostly caused by bacteria, e.g. Pseudomonas aeruginosa (PA). The role of fungi in the CF lung is still not well elucidated, but evidence for a harmful and complex role is getting stronger. The most common filamentous fungus in CF is Aspergillus fumigatus (AF). Age and continuous antibiotic treatment have been discussed as risk factors for AF colonisation but did not differentiate between transient and persistent AF colonisation. Also, the impact of co-colonisation of PA and AF on lung function is still under investigation. Data from patients with CF registered in the German Cystic Fibrosis Registry database in 2016 and 2017 were retrospectively analysed, involving descriptive and multivariate analysis to assess risk factors for transient or persistent AF colonisation. Age represented an independent risk factor for persistent AF colonisation. Prevalence was low in children less than ten years, highest in the middle age and getting lower in higher age (≥ 50 years). Continuous antibiotic lung treatment was significantly associated with AF prevalence in all age groups. CF patients with chronic PA infection had a lower lung function (FEV1%predicted), which was not influenced by an additional AF colonisation. AF colonisation without chronic PA infection, however, was significantly associated with a lower function, too. Older age up to 49 years and continuous antibiotic use were found to be the main risk factors for AF permanent colonisation. AF might be associated with decrease of lung function if not disguised by chronic PA infection.

scholarly journals Ceramide in Cystic Fibrosis: A Potential New Target for Therapeutic Intervention

2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Gabriella Wojewodka ◽  
Juan B. De Sanctis ◽  
Danuta Radzioch
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Inflammatory Response ◽  
Therapeutic Intervention ◽  
Bacterial Infections ◽  
Potential Role ◽  
Cell Signalling ◽  
Membrane Microdomains ◽  
Molecular Processes

Patients with cystic fibrosis (CF) are afflicted with many symptoms but the greatest challenge is the fight against chronic bacterial infections, leading to decreased lung function and ultimately death. Our group has recently found reduced levels of ceramides in CF patients and mice. Ceramides are sphingolipids involved in the structure of cell membranes but also participate in the inflammatory response, in cell signalling through membrane microdomains (lipid rafts), and in apoptosis. These characteristics of ceramides make them strong candidates for therapeutic intervention in CF. As more studies have come to evaluate the role of ceramide in CF, conflicting results have been described. This paper discusses various views regarding the potential role of ceramide in CF, summarizes methods of ceramide detection and their role in the regulation of cellular and molecular processes.

scholarly journals Cystic fibrosis-related diabetes and lung disease: an update

2021 ◽  
Vol 30 (159) ◽  
pp. 200293
Author(s):  
Bernadette J. Prentice ◽  
Adam Jaffe ◽  
Shihab Hameed ◽  
Charles F. Verge ◽  
Shafagh Waters ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
High Glucose ◽  
Potential Role ◽  
Early Mortality ◽  
Genetic Modifiers ◽  
Immunomodulatory Effects ◽  
Glucose Levels ◽  
The Many

The development of cystic fibrosis-related diabetes (CFRD) often leads to poorer outcomes in patients with cystic fibrosis including increases in pulmonary exacerbations, poorer lung function and early mortality. This review highlights the many factors contributing to the clinical decline seen in patients diagnosed with CFRD, highlighting the important role of nutrition, the direct effect of hyperglycaemia on the lungs, the immunomodulatory effects of high glucose levels and the potential role of genetic modifiers in CFRD.

scholarly journals Clinafloxacin for Treatment of Burkholderia cenocepacia Infection in a Cystic Fibrosis Patient

2015 ◽  
Vol 60 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Akshu Balwan ◽  
David P. Nicolau ◽  
Minkey Wungwattana ◽  
Jonathan B. Zuckerman ◽  
Valerie Waters
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Cystic Fibrosis Patient ◽  
Respir Crit ◽  
Burkholderia Cenocepacia ◽  
Content Type ◽  
Link Type ◽  
Potential Therapeutic Role ◽  
Established Infection

ABSTRACTRespiratory infection withBurkholderia cenocepaciais associated with accelerated decline in lung function and increased mortality in cystic fibrosis (CF) patients (A. M. Jones, M. E. Dodd, J. R. W. Govan, V. Barcus, C. J. Doherty, J. Morris, and A. K. Webb, Thorax 59:948–951, 2004,http://dx.doi.org/10.1136/thx.2003.017210).B. cenocepaciaoften possesses innate resistance to multiple antimicrobial classes, making eradication uncommon in established infection (P. B. Davis, Am J Respir Crit Care Med 173:475–482, 2006,http://dx.doi.org/10.1164/rccm.200505-840OE). We report the use of clinafloxacin in a CF patient with advancedB. cenocepaciainfection, present pharmacokinetic (PK) data, and discuss the potential therapeutic role of clinafloxacin in patients with this condition.

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