scholarly journals Low-dimensional morphospace of topological motifs in human fMRI brain networks

2018 ◽  
Vol 2 (2) ◽  
pp. 285-302 ◽  
Author(s):  
Sarah E. Morgan ◽  
Sophie Achard ◽  
Maite Termenon ◽  
Edward T. Bullmore ◽  
Petra E. Vértes
Keyword(s):  
World Trade ◽  
Brain Networks ◽  
Small World ◽  
Generative Models ◽  
Data Driven ◽  
Functional Networks ◽  
Network Motifs ◽  
Trade Off ◽  
Network Properties ◽  
Low Dimensional

We present a low-dimensional morphospace of fMRI brain networks, where axes are defined in a data-driven manner based on the network motifs. The morphospace allows us to identify the key variations in healthy fMRI networks in terms of their underlying motifs, and we observe that two principal components (PCs) can account for 97% of the motif variability. The first PC of the motif distribution is correlated with efficiency and inversely correlated with transitivity. Hence this axis approximately conforms to the well-known economical small-world trade-off between integration and segregation in brain networks. Finally, we show that the economical clustering generative model proposed by Vértes et al. ( 2012 ) can approximately reproduce the motif morphospace of the real fMRI brain networks, in contrast to other generative models. Overall, the motif morphospace provides a powerful way to visualize the relationships between network properties and to investigate generative or constraining factors in the formation of complex human brain functional networks.

scholarly journals Low dimensional morphospace of topological motifs in human fMRI brain networks

2017 ◽  
Author(s):  
Sarah E. Morgan ◽  
Sophie Achard ◽  
Maite Termenon ◽  
Petra E. Vértes ◽  
Edward T. Bullmore
Keyword(s):  
Driving Forces ◽  
Average Length ◽  
Brain Networks ◽  
Small World ◽  
Generative Models ◽  
Data Driven ◽  
Long Distance ◽  
Network Properties ◽  
Low Dimensional ◽  
The Cost

AbstractWe present a low-dimensional morphospace of fMRI brain networks, where axes are defined in a data-driven manner based on the network motifs. The morphospace allows us to identify the key variations in healthy fMRI networks in terms of their underlying motifs and we observe that two principal components (PCs) can account for 97% of the motif variability. The first PC corresponds to the small-world axis and correlates strongly with the networks’ global efficiency. There is also some evidence that PC1 correlates with the average length of the 5% of longest edges in the network. Hence this axis represents the trade-off between the cost of long distance edges and their topological benefits. The second PC correlates with the networks’ assortativity. Finally, we show that the economical clustering generative model proposed by Vértes et al. can approximately reproduce the motif PC space of the real fMRI brain networks, in contrast to other generative models. Overall, the motif morphospace provides a powerful way to visualise the relationships between network properties and to study the driving forces behind the topology of fMRI brain networks.

scholarly journals Disrupted resting-state brain network properties in obesity: decreased global and putaminal cortico-striatal network efficiency

2016 ◽  
Vol 47 (4) ◽  
pp. 585-596 ◽  
Author(s):  
K. Baek ◽  
L. S. Morris ◽  
P. Kundu ◽  
V. Voon
Keyword(s):  
Resting State ◽  
Brain Networks ◽  
Brain Network ◽  
Data Driven ◽  
Local Network ◽  
Healthy Controls ◽  
Network Efficiency ◽  
Whole Brain ◽  
Network Properties ◽  
Obese Subjects

BackgroundThe efficient organization and communication of brain networks underlie cognitive processing and their disruption can lead to pathological behaviours. Few studies have focused on whole-brain networks in obesity and binge eating disorder (BED). Here we used multi-echo resting-state functional magnetic resonance imaging (rsfMRI) along with a data-driven graph theory approach to assess brain network characteristics in obesity and BED.MethodMulti-echo rsfMRI scans were collected from 40 obese subjects (including 20 BED patients) and 40 healthy controls and denoised using multi-echo independent component analysis (ME-ICA). We constructed a whole-brain functional connectivity matrix with normalized correlation coefficients between regional mean blood oxygenation level-dependent (BOLD) signals from 90 brain regions in the Automated Anatomical Labeling atlas. We computed global and regional network properties in the binarized connectivity matrices with an edge density of 5%–25%. We also verified our findings using a separate parcellation, the Harvard–Oxford atlas parcellated into 470 regions.ResultsObese subjects exhibited significantly reduced global and local network efficiency as well as decreased modularity compared with healthy controls, showing disruption in small-world and modular network structures. In regional metrics, the putamen, pallidum and thalamus exhibited significantly decreased nodal degree and efficiency in obese subjects. Obese subjects also showed decreased connectivity of cortico-striatal/cortico-thalamic networks associated with putaminal and cortical motor regions. These findings were significant with ME-ICA with limited group differences observed with conventional denoising or single-echo analysis.ConclusionsUsing this data-driven analysis of multi-echo rsfMRI data, we found disruption in global network properties and motor cortico-striatal networks in obesity consistent with habit formation theories. Our findings highlight the role of network properties in pathological food misuse as possible biomarkers and therapeutic targets.

scholarly journals Multiple Functional Brain Networks Related to Pain Perception Revealed by fMRI

2021 ◽  
Author(s):  
Matteo Damascelli ◽  
Todd S. Woodward ◽  
Nicole Sanford ◽  
Hafsa B. Zahid ◽  
Ryan Lim ◽  
...  
Keyword(s):  
Pain Perception ◽  
Brain Networks ◽  
Data Driven ◽  
Functional Networks ◽  
Brain State ◽  
Imaging Data ◽  
Whole Brain ◽  
Functional Brain ◽  
Network Activation ◽  
Functional Brain Networks

AbstractThe rise of functional magnetic resonance imaging (fMRI) has led to a deeper understanding of cortical processing of pain. Central to these advances has been the identification and analysis of “functional networks”, often derived from groups of pre-selected pain regions. In this study our main objective was to identify functional brain networks related to pain perception by examining whole-brain activation, avoiding the need for a priori selection of regions. We applied a data-driven technique—Constrained Principal Component Analysis for fMRI (fMRI-CPCA)—that identifies networks without assuming their anatomical or temporal properties. Open-source fMRI data collected during a thermal pain task (33 healthy participants) were subjected to fMRI-CPCA for network extraction, and networks were associated with pain perception by modelling subjective pain ratings as a function of network activation intensities. Three functional networks emerged: a sensorimotor response network, a salience-mediated attention network, and the default-mode network. Together, these networks constituted a brain state that explained variability in pain perception, both within and between individuals, demonstrating the potential of data-driven, whole-brain functional network techniques for the analysis of pain imaging data.

Extended-Range Prediction with Low-Dimensional, Stochastic-Dynamic Models: A Data-driven Approach

2012 ◽  
Author(s):  
Michael Ghil ◽  
Mickael D. Chekroun ◽  
Dmitri Kondrashov ◽  
Michael K. Tippett ◽  
Andrew Robertson ◽  
...  
Keyword(s):  
Dynamic Models ◽  
Data Driven ◽  
Stochastic Dynamic ◽  
Extended Range ◽  
Data Driven Approach ◽  
Low Dimensional

Network Embedding on Hierarchical Community Structure Network

2021 ◽  
Vol 15 (4) ◽  
pp. 1-23
Author(s):  
Guojie Song ◽  
Yun Wang ◽  
Lun Du ◽  
Yi Li ◽  
Junshan Wang
Keyword(s):  
Community Structure ◽  
Structural Information ◽  
Spherical Surface ◽  
Network Embedding ◽  
The Galaxy ◽  
Community Information ◽  
The Hierarchical Structure ◽  
Network Properties ◽  
Multi Class Classification ◽  
Low Dimensional

Network embedding is a method of learning a low-dimensional vector representation of network vertices under the condition of preserving different types of network properties. Previous studies mainly focus on preserving structural information of vertices at a particular scale, like neighbor information or community information, but cannot preserve the hierarchical community structure, which would enable the network to be easily analyzed at various scales. Inspired by the hierarchical structure of galaxies, we propose the Galaxy Network Embedding (GNE) model, which formulates an optimization problem with spherical constraints to describe the hierarchical community structure preserving network embedding. More specifically, we present an approach of embedding communities into a low-dimensional spherical surface, the center of which represents the parent community they belong to. Our experiments reveal that the representations from GNE preserve the hierarchical community structure and show advantages in several applications such as vertex multi-class classification, network visualization, and link prediction. The source code of GNE is available online.

Computational Capacity of Complex Memcapacitive Networks

2021 ◽  
Vol 17 (2) ◽  
pp. 1-25
Author(s):  
Dat Tran ◽  
Christof Teuscher
Keyword(s):  
Power Consumption ◽  
Small World ◽  
Fading Memory ◽  
Reservoir Computing ◽  
Topological Transformation ◽  
Trade Off ◽  
Topological Structures ◽  
Computational Capacity ◽  
Computational Capability ◽  
Comparable Performance

Emerging memcapacitive nanoscale devices have the potential to perform computations in new ways. In this article, we systematically study, to the best of our knowledge for the first time, the computational capacity of complex memcapacitive networks, which function as reservoirs in reservoir computing, one of the brain-inspired computing architectures. Memcapacitive networks are composed of memcapacitive devices randomly connected through nanowires. Previous studies have shown that both regular and random reservoirs provide sufficient dynamics to perform simple tasks. How do complex memcapacitive networks illustrate their computational capability, and what are the topological structures of memcapacitive networks that solve complex tasks with efficiency? Studies show that small-world power-law (SWPL) networks offer an ideal trade-off between the communication properties and the wiring cost of networks. In this study, we illustrate the computing nature of SWPL memcapacitive reservoirs by exploring the two essential properties: fading memory and linear separation through measurements of kernel quality. Compared to ideal reservoirs, nanowire memcapacitive reservoirs had a better dynamic response and improved their performance by 4.67% on three tasks: MNIST, Isolated Spoken Digits, and CIFAR-10. On the same three tasks, compared to memristive reservoirs, nanowire memcapacitive reservoirs achieved comparable performance with much less power, on average, about 99× , 17×, and 277×, respectively. Simulation results of the topological transformation of memcapacitive networks reveal that that topological structures of the memcapacitive SWPL reservoirs did not affect their performance but significantly contributed to the wiring cost and the power consumption of the systems. The minimum trade-off between the wiring cost and the power consumption occurred at different network settings of α and β : 4.5 and 0.61 for Biolek reservoirs, 2.7 and 1.0 for Mohamed reservoirs, and 3.0 and 1.0 for Najem reservoirs. The results of our research illustrate the computational capacity of complex memcapacitive networks as reservoirs in reservoir computing. Such memcapacitive networks with an SWPL topology are energy-efficient systems that are suitable for low-power applications such as mobile devices and the Internet of Things.

Deep Learning for the Automated Classification of Functional Brain Networks in fMRI (Preprint)

2021 ◽  
Author(s):  
Lukman Ismael ◽  
Pejman Rasti ◽  
Florian Bernard ◽  
Philippe Menei ◽  
Aram Ter Minassian ◽  
...  
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Learning Algorithms ◽  
Brain Networks ◽  
Learning Model ◽  
Machine Learning Algorithms ◽  
Functional Networks ◽  
Functional Brain ◽  
Functional Brain Networks ◽  
Deep Learning Model

BACKGROUND The functional MRI (fMRI) is an essential tool for the presurgical planning of brain tumor removal, allowing the identification of functional brain networks in order to preserve the patient’s neurological functions. One fMRI technique used to identify the functional brain network is the resting-state-fMRI (rsfMRI). However, this technique is not routinely used because of the necessity to have a expert reviewer to identify manually each functional networks. OBJECTIVE We aimed to automatize the detection of brain functional networks in rsfMRI data using deep learning and machine learning algorithms METHODS We used the rsfMRI data of 82 healthy patients to test the diagnostic performance of our proposed end-to-end deep learning model to the reference functional networks identified manually by 2 expert reviewers. RESULTS Experiment results show the best performance of 86% correct recognition rate obtained from the proposed deep learning architecture which shows its superiority over other machine learning algorithms that were equally tested for this classification task. CONCLUSIONS The proposed end-to-end deep learning model was the most performant machine learning algorithm. The use of this model to automatize the functional networks detection in rsfMRI may allow to broaden the use of the rsfMRI, allowing the presurgical identification of these networks and thus help to preserve the patient’s neurological status. CLINICALTRIAL Comité de protection des personnes Ouest II, decision reference CPP 2012-25)

scholarly journals Psychological resilience correlates with EEG source-space brain network flexibility

2019 ◽  
Vol 3 (2) ◽  
pp. 539-550 ◽  
Author(s):  
Véronique Paban ◽  
Julien Modolo ◽  
Ahmad Mheich ◽  
Mahmoud Hassan
Keyword(s):  
Brain Networks ◽  
Brain Regions ◽  
Brain Network ◽  
Personality Testing ◽  
Functional Networks ◽  
Psychological Resilience ◽  
Full Spectrum ◽  
Sliding Windows ◽  
Resilience Scale ◽  
Network Flexibility

We aimed at identifying the potential relationship between the dynamical properties of the human functional network at rest and one of the most prominent traits of personality, namely resilience. To tackle this issue, we used resting-state EEG data recorded from 45 healthy subjects. Resilience was quantified using the 10-item Connor-Davidson Resilience Scale (CD-RISC). By using a sliding windows approach, brain networks in each EEG frequency band (delta, theta, alpha, and beta) were constructed using the EEG source-space connectivity method. Brain networks dynamics were evaluated using the network flexibility, linked with the tendency of a given node to change its modular affiliation over time. The results revealed a negative correlation between the psychological resilience and the brain network flexibility for a limited number of brain regions within the delta, alpha, and beta bands. This study provides evidence that network flexibility, a metric of dynamic functional networks, is strongly correlated with psychological resilience as assessed from personality testing. Beyond this proof-of-principle that reliable EEG-based quantities representative of personality traits can be identified, this motivates further investigation regarding the full spectrum of personality aspects and their relationship with functional networks.

scholarly journals Small world in a seismic network: the California case

2008 ◽  
Vol 15 (3) ◽  
pp. 389-395 ◽  
Author(s):  
A. Jiménez ◽  
K. F. Tiampo ◽  
A. M. Posadas
Keyword(s):  
Complex Networks ◽  
Recent Work ◽  
Brain Activity ◽  
Social Systems ◽  
Small World ◽  
Functional Networks ◽  
Topological Properties ◽  
Southern California Region ◽  
Seismic Area ◽  
The Brain

Abstract. Recent work has shown that disparate systems can be described as complex networks i.e. assemblies of nodes and links with nontrivial topological properties. Examples include technological, biological and social systems. Among them, earthquakes have been studied from this perspective. In the present work, we divide the Southern California region into cells of 0.1°, and calculate the correlation of activity between them to create functional networks for that seismic area, in the same way that the brain activity is studied from the complex network perspective. We found that the network shows small world features.

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