Art as a Stimulus for Structural DNA Nanotechnology

Leonardo ◽  
2014 ◽  
Vol 47 (2) ◽  
pp. 142-149 ◽  
Author(s):  
Nadrian C. Seeman
Keyword(s):  
Molecular Crystal ◽  
Dna Nanotechnology ◽  
Helical Structure ◽  
Dna Molecules ◽  
Dna Motifs ◽  
Double Helical Structure ◽  
Branched Dna ◽  
Sticky Ends ◽  
Structural Dna Nanotechnology ◽  
The Relationship

The linear, double-helical structure of DNA was initially recognized as beautiful, as well as being informative about the mechanism of heredity. Recently, branched DNA molecules have been used to produce nanoscale objects, crystals and machines, all the products of a new field: structural DNA nanotechnology. The inspiration for much of this work has been art, starting from the notion that Escher's woodcut Depth was analogous to a molecular crystal of branched DNA. The article describes how connecting branched molecules together with the “sticky ends” used by genetic engineers has led to 3D crystals, and how Dalí's Butterfly Landscape illuminates the relationship between wrappings of DNA and the crossings in knots or links. Disparate aesthetic patterns are related to branched DNA motifs and constructions.

scholarly journals DNA enables nanoscale control of the structure of matter

2005 ◽  
Vol 38 (4) ◽  
pp. 363-371 ◽  
Author(s):  
Nadrian C. Seeman
Keyword(s):  
Specific Binding ◽  
Dna Nanotechnology ◽  
Biological Macromolecules ◽  
Structural Transitions ◽  
Dna Molecules ◽  
Borromean Rings ◽  
Periodic Arrays ◽  
Branched Dna ◽  
Structural Dna Nanotechnology ◽  
Structure Of Matter

1. Introduction 3632. Motif and sequence design 3643. Structural and topological constructions 3664. Nanomechanical devices 3675. Conclusions, applications and challenges 3706. Acknowledgments 3717. References 371Structural DNA nanotechnology consists of constructing objects, lattices and devices from branched DNA molecules. Branched DNA molecules open the way for the construction of a variety of N-connected motifs. These motifs can be joined by cohesive interactions to produce larger constructs in a bottom-up approach to nanoconstruction. The first objects produced by this approach were stick polyhedra and topological targets, such as knots and Borromean rings. These were followed by periodic arrays with programmable patterns. It is possible to exploit DNA structural transitions and sequence-specific binding to produce a variety of DNA nanomechanical devices, which include a bipedal walker and a machine that emulates the translational capabilities of the ribosome. Much of the promise of this methodology involves the use of DNA to scaffold other materials, such as biological macromolecules, nanoelectronic components, and polymers. These systems are designed to lead to improvements in crystallography, computation and the production of diverse and exotic materials.

scholarly journals The Helicity of a DNA-2’-Fluoro DNA Hybrid Duplex Structure

2017 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Double Helix ◽  
Dna Nanotechnology ◽  
Helical Structure ◽  
Hydrogen Atoms ◽  
Atomic Force ◽  
Hybrid Duplex ◽  
Dna Backbone ◽  
Helical Turn ◽  
Dna 2 ◽  
Structural Dna Nanotechnology

Structural DNA nanotechnology is a system whereby branched DNA molecules are fashioned into objects, or 1D, 2D and 3D lattices, as well as nanomechanical devices. Normally, one is dealing with the usual B-form DNA molecule, but variations on this theme can lead to alterations in both the structures and the properties of the constructs. 2’-Fluoro DNA (FDNA), wherein one of the hydrogen atoms of the 2’ carbon is replaced by a fluorine atom, is a minimal steric perturbation on the structure of the DNA backbone. The helical structure of this duplex is of great interest for applications in structural DNA nanotechnology, because the DNA-FDNA hybrid assumes an A-form double helix, without the instabilities associated with RNA. Here we have used an atomic force microscopic method to estimate the helicity of DNA-FDNA hybrids, and we find that the structure contains 11.8 nucleotide pairs per helical turn with an error of ± 0.6 nucleotide pairs, similar to other A-form molecules.

Ground Surface Deformation Sensor Based on Cable Impedance

2012 ◽  
Vol 241-244 ◽  
pp. 998-1003
Author(s):  
Ren Yuan Tong ◽  
Qing Li ◽  
Ming Li ◽  
Xiong Li
Keyword(s):  
Surface Deformation ◽  
Ground Surface ◽  
Helical Structure ◽  
Measurement Range ◽  
Impedance Change ◽  
Impedance Analyzer ◽  
Double Helical Structure ◽  
Stretching Deformation ◽  
The Relationship ◽  
Precision Impedance Analyzer

In order to measure ground surface deformation, a sensor based on cable impedance change is studied in this paper. This sensing cable has elastic double helical structure with much larger measurement range than optical fiber distributed deformation technology. Using the precision impedance analyzer, we obtain the relationship between elongation and impedance of the sensing cable and choose one of the frequent as the measurement frequency. A ground surface deformation measuring circuit is designed for the sensing cable. Deformation experiment shows that the relationship between sensing cable impedance and stretching deformation is approximately linearity, when the deformation is small.

Atomistic to Continuum Modeling of DNA Molecules

2010 ◽  
Author(s):  
C. H. Lee ◽  
H. Teng ◽  
J. S. Chen
Keyword(s):  
Mechanical Properties ◽  
Helical Structure ◽  
Confined Space ◽  
Dna Molecules ◽  
Continuum Modeling ◽  
Replication Process ◽  
Double Helical Structure ◽  
Biological Implication

The mechanical properties of DNA has very important biological implication. For example, the bending and twisting rigidities of DNA affect how it wraps around histones to form chromosomes, bends upon interactions with proteins, supercoils during replication process, and packs into the confined space within a virus. Many biologically important processes involving DNA are accompanied by the deformations of double helical structure of DNA.

Single-molecule methods in structural DNA nanotechnology

2020 ◽  
Vol 49 (13) ◽  
pp. 4220-4233 ◽  
Author(s):  
Casey M. Platnich ◽  
Felix J. Rizzuto ◽  
Gonzalo Cosa ◽  
Hanadi F. Sleiman
Keyword(s):  
Single Molecule ◽  
Method Development ◽  
Dna Nanotechnology ◽  
Dna Nanostructures ◽  
Structural Dna Nanotechnology ◽  
The Relationship

In this tutorial review, we explore the suite of single-molecule techniques currently available to probe DNA nanostructures and highlight the relationship between single-molecule method development and DNA nanotechology.

scholarly journals Strategies to Build Hybrid Protein–DNA Nanostructures

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1332
Author(s):  
Armando Hernandez-Garcia
Keyword(s):  
Dynamic Systems ◽  
Dna Nanotechnology ◽  
Chemical Properties ◽  
Hybrid Nanostructures ◽  
Advanced Materials ◽  
Dna Nanostructures ◽  
Hybrid Protein ◽  
Structural Protein ◽  
The Individual ◽  
Structural Dna Nanotechnology

Proteins and DNA exhibit key physical chemical properties that make them advantageous for building nanostructures with outstanding features. Both DNA and protein nanotechnology have growth notably and proved to be fertile disciplines. The combination of both types of nanotechnologies is helpful to overcome the individual weaknesses and limitations of each one, paving the way for the continuing diversification of structural nanotechnologies. Recent studies have implemented a synergistic combination of both biomolecules to assemble unique and sophisticate protein–DNA nanostructures. These hybrid nanostructures are highly programmable and display remarkable features that create new opportunities to build on the nanoscale. This review focuses on the strategies deployed to create hybrid protein–DNA nanostructures. Here, we discuss strategies such as polymerization, spatial directing and organizing, coating, and rigidizing or folding DNA into particular shapes or moving parts. The enrichment of structural DNA nanotechnology by incorporating protein nanotechnology has been clearly demonstrated and still shows a large potential to create useful and advanced materials with cell-like properties or dynamic systems. It can be expected that structural protein–DNA nanotechnology will open new avenues in the fabrication of nanoassemblies with unique functional applications and enrich the toolbox of bionanotechnology.

scholarly journals Hybrid Nanoassemblies from Viruses and DNA Nanostructures

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1413
Author(s):  
Sofia Ojasalo ◽  
Petteri Piskunen ◽  
Boxuan Shen ◽  
Mauri A. Kostiainen ◽  
Veikko Linko
Keyword(s):  
Cell Activation ◽  
Immune Cell ◽  
Dna Nanotechnology ◽  
Biological Properties ◽  
Dna Nanostructures ◽  
Dna Structures ◽  
Nanoscale Structures ◽  
Immune Cell Activation ◽  
Wide Range ◽  
Structural Dna Nanotechnology

Viruses are among the most intriguing nanostructures found in nature. Their atomically precise shapes and unique biological properties, especially in protecting and transferring genetic information, have enabled a plethora of biomedical applications. On the other hand, structural DNA nanotechnology has recently emerged as a highly useful tool to create programmable nanoscale structures. They can be extended to user defined devices to exhibit a wide range of static, as well as dynamic functions. In this review, we feature the recent development of virus-DNA hybrid materials. Such structures exhibit the best features of both worlds by combining the biological properties of viruses with the highly controlled assembly properties of DNA. We present how the DNA shapes can act as “structured” genomic material and direct the formation of virus capsid proteins or be encapsulated inside symmetrical capsids. Tobacco mosaic virus-DNA hybrids are discussed as the examples of dynamic systems and directed formation of conjugates. Finally, we highlight virus-mimicking approaches based on lipid- and protein-coated DNA structures that may elicit enhanced stability, immunocompatibility and delivery properties. This development also paves the way for DNA-based vaccines as the programmable nano-objects can be used for controlling immune cell activation.

scholarly journals Living supramolecular polymerization of fluorinated cyclohexanes

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Oleksandr Shyshov ◽  
Shyamkumar Vadakket Haridas ◽  
Luca Pesce ◽  
Haoyuan Qi ◽  
Andrea Gardin ◽  
...  
Keyword(s):  
Dipole Moment ◽  
Self Assembly ◽  
Materials Science ◽  
Helical Structure ◽  
The Self ◽  
Supramolecular Polymers ◽  
Aliphatic Compound ◽  
Double Helical Structure ◽  
Key Driver ◽  
Supramolecular Polymerization

AbstractThe development of powerful methods for living covalent polymerization has been a key driver of progress in organic materials science. While there have been remarkable reports on living supramolecular polymerization recently, the scope of monomers is still narrow and a simple solution to the problem is elusive. Here we report a minimalistic molecular platform for living supramolecular polymerization that is based on the unique structure of all-cis 1,2,3,4,5,6-hexafluorocyclohexane, the most polar aliphatic compound reported to date. We use this large dipole moment (6.2 Debye) not only to thermodynamically drive the self-assembly of supramolecular polymers, but also to generate kinetically trapped monomeric states. Upon addition of well-defined seeds, we observed that the dormant monomers engage in a kinetically controlled supramolecular polymerization. The obtained nanofibers have an unusual double helical structure and their length can be controlled by the ratio between seeds and monomers. The successful preparation of supramolecular block copolymers demonstrates the versatility of the approach.

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