scholarly journals Moving average procedures as an additional tool for real-time analytical quality control: challenges and opportunities of implementation in small-volume medical laboratories

2021 ◽  
Vol 32 (1) ◽  
Author(s):  
Vera Lukić ◽  
Svetlana Ignjatović
Keyword(s):  
Quality Control ◽  
Real Time ◽  
Small Volume ◽  
Moving Average ◽  
Analytical Quality Control ◽  
Analytical Quality ◽  
Additional Tool ◽  
Medical Laboratories ◽  
Challenges And Opportunities

Benefits, limitations, and controversies on patient-based real-time quality control (PBRTQC) and the evidence behind the practice

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Huub H. van Rossum ◽  
Andreas Bietenbeck ◽  
Mark A. Cervinski ◽  
Alex Katayev ◽  
Tze Ping Loh ◽  
...  
Keyword(s):  
Quality Control ◽  
Real Time ◽  
Cost Efficiency ◽  
Moving Average ◽  
Daily Practice ◽  
Added Value ◽  
Current Status ◽  
Average Quality ◽  
Medical Laboratories ◽  
Recent Developments

Abstract Background In recent years, there has been renewed interest in the “old” average of normals concept, now generally referred to as moving average quality control (MA QC) or patient-based real-time quality control (PBRTQC). However, there are some controversies regarding PBRTQC which this review aims to address while also indicating the current status of PBRTQC. Content This review gives the background of certain newly described optimization and validation methods. It also indicates how QC plans incorporating PBRTQC can be designed for greater effectiveness and/or (cost) efficiency. Furthermore, it discusses controversies regarding the complexity of obtaining PBRTQC settings, the replacement of iQC, and software functionality requirements. Finally, it presents evidence of the added value and practicability of PBRTQC. Outlook Recent developments in, and availability of, simulation methods to optimize and validate laboratory-specific PBRTQC procedures have enabled medical laboratories to implement PBRTQC in their daily practice. Furthermore, these methods have made it possible to demonstrate the practicability and added value of PBRTQC by means of two prospective “clinical” studies and other investigations. Although internal QC will remain an essential part of any QC plan, applying PBRTQC can now significantly improve its performance and (cost) efficiency.

Implementation and application of moving average as continuous analytical quality control instrument demonstrated for 24 routine chemistry assays

2017 ◽  
Vol 55 (8) ◽  
pp. 1142-1151 ◽  
Author(s):  
Huub H. van Rossum ◽  
Hans Kemperman
Keyword(s):  
Quality Control ◽  
Moving Average ◽  
Working Hours ◽  
Daily Practice ◽  
Analytical Quality Control ◽  
Analytical Quality ◽  
Simple Method ◽  
Control Instrument ◽  
Significant Difference ◽  
Bias Detection

Abstract Background: General application of a moving average (MA) as continuous analytical quality control (QC) for routine chemistry assays has failed due to lack of a simple method that allows optimization of MAs. A new method was applied to optimize the MA for routine chemistry and was evaluated in daily practice as continuous analytical QC instrument. Methods: MA procedures were optimized using an MA bias detection simulation procedure. Optimization was graphically supported by bias detection curves. Next, all optimal MA procedures that contributed to the quality assurance were run for 100 consecutive days and MA alarms generated during working hours were investigated. Results: Optimized MA procedures were applied for 24 chemistry assays. During this evaluation, 303,871 MA values and 76 MA alarms were generated. Of all alarms, 54 (71%) were generated during office hours. Of these, 41 were further investigated and were caused by ion selective electrode (ISE) failure (1), calibration failure not detected by QC due to improper QC settings (1), possible bias (significant difference with the other analyzer) (10), non-human materials analyzed (2), extreme result(s) of a single patient (2), pre-analytical error (1), no cause identified (20), and no conclusion possible (4). Conclusions: MA was implemented in daily practice as a continuous QC instrument for 24 routine chemistry assays. In our setup when an MA alarm required follow-up, a manageable number of MA alarms was generated that resulted in valuable MA alarms. For the management of MA alarms, several applications/requirements in the MA management software will simplify the use of MA procedures.

Analytical Quality Control (AQC) For Monitoring Trace Metals in the Coastal and Estuarine Environment

1986 ◽  
Vol 18 (4-5) ◽  
pp. 35-41 ◽  
Author(s):  
M. J. Gardner ◽  
D T. E. Hunt ◽  
G. Topping
Keyword(s):  
Quality Control ◽  
Trace Metals ◽  
Marine Pollution ◽  
Pollution Monitoring ◽  
Research Centre ◽  
Analytical Quality Control ◽  
Analytical Quality ◽  
Management Group ◽  
Analytical Results ◽  
Saline Waters

It is widely recognised that, unless special steps are taken, analytical results from a group of laboratories engaged in a monitoring programme are likely to be of poor comparability. This in turn can prejudice the conclusions drawn from the results of monitoring. On the basis of previous studies, the problem is known to be particularly acute for measurements of trace metals in saline waters. Recognising the difficulty, the Marine Pollution Monitoring Management Group (MPMMG) and the Water Research centre (WRc) have organised a programme of Analytical Quality Control (AQC). This has the objective of ensuring that analytical results for filterable cadmium and mercury in saline waters, obtained by water industry and other relevant laboratories, are of adequate accuracy and comparability for their intended uses. WRc is to coordinate a series of tests, some involving distributions of standards and samples, which the participating laboratories undertake; this series of tests, the background to the approach and some of the results obtained to date are described here.

Importance of implementing an analytical quality control system in a core laboratory

2015 ◽  
Vol 30 (6) ◽  
pp. 302-309 ◽  
Author(s):  
F. Marques-Garcia ◽  
M.F. Garcia-Codesal ◽  
M.R. Caro-Narros ◽  
T. Contreras-SanFeliciano
Keyword(s):  
Quality Control ◽  
Control System ◽  
Quality Control System ◽  
Analytical Quality Control ◽  
Analytical Quality

scholarly journals In situ Analytical Quality Control of chemotherapeutic solutions in infusion bags by Raman spectroscopy

Talanta ◽  
2021 ◽  
Vol 228 ◽  
pp. 122137
Author(s):  
Alaa A. Makki ◽  
Suha Elderderi ◽  
Victor Massot ◽  
Renaud Respaud ◽  
Hugh.J. Byrne ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Quality Control ◽  
Analytical Quality Control ◽  
Analytical Quality

scholarly journals Production and Use of BCR Reference Materials for Quality Assurance in Environmental Analysis: An Update

2001 ◽  
Vol 84 (6) ◽  
pp. 1786-1792 ◽  
Author(s):  
Philippe Quevauviller
Keyword(s):  
Quality Control ◽  
Quality Assurance ◽  
Reference Materials ◽  
Environmental Analysis ◽  
Control Charts ◽  
Certified Reference Materials ◽  
Background Information ◽  
Analytical Quality Control ◽  
Analytical Quality ◽  
Invaluable Tool

Abstract Reference materials represent an invaluable tool for analytical quality control. Certified Reference Materials (CRMs) are used for the validation of methods, whereas various types of (uncertified) Reference Materials (RMs) are used for routine quality control (establishment of control charts) and interlaboratory testing (e.g., proficiency testing). This paper provides background information on the production and use of environmental RMs and describes recent CRMs produced by the BCR (European Commission) for quality assurance in environmental analysis.

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