scholarly journals Gamma heavy-chain disease accompanied with follicular lymphoma: a case report

2018 ◽  
Vol 28 (1) ◽  
Author(s):  
Paula San-José ◽  
Vicente Aguadero ◽  
Granada Perea ◽  
Meritxell Estrada ◽  
Eugenio Berlanga
Keyword(s):  
Case Report ◽  
Follicular Lymphoma ◽  
Heavy Chain ◽  
Heavy Chain Disease

Heavy chain disease: a rare case report of adult nephrotic syndrome

2019 ◽  
Vol 19 (4) ◽  
pp. 129
Author(s):  
ChettipunyamSounderrajan Chetan ◽  
SanjeevS Manjunath ◽  
Satish Suchitha ◽  
Gangadhar Chirag
Keyword(s):  
Nephrotic Syndrome ◽  
Case Report ◽  
Heavy Chain ◽  
Rare Case ◽  
Rare Case Report ◽  
Heavy Chain Disease

scholarly journals T cell receptor rearrangements in a patient with γ-heavy chain disease: A case report

2016 ◽  
Vol 11 (6) ◽  
pp. 4147-4151
Author(s):  
HEBING ZHOU ◽  
WENMING CHEN ◽  
JUAN ZHANG ◽  
HUI ZENG ◽  
YUAN JIAN ◽  
...  
Keyword(s):  
Case Report ◽  
T Cell ◽  
T Cell Receptor ◽  
Heavy Chain ◽  
Cell Receptor ◽  
Heavy Chain Disease

Successful Treatment of µ-Heavy Chain Disease with Fludarabine Monophosphate: A Case Report

2004 ◽  
Vol 79 (2) ◽  
pp. 174-177 ◽  
Author(s):  
Machi Yanai ◽  
Akinori Maeda ◽  
Naoko Watanabe ◽  
Naoshi Sugimoto ◽  
Akiko Matsushita ◽  
...  
Keyword(s):  
Case Report ◽  
Heavy Chain ◽  
Successful Treatment ◽  
Fludarabine Monophosphate ◽  
Heavy Chain Disease

scholarly journals Gamma Heavy Chain Disease with T-cell Large Granular Lymphocytic Leukemia: A Case Report and Review of the Literature

2016 ◽  
Vol 55 (4) ◽  
pp. 399-403 ◽  
Author(s):  
Masahide Iijima ◽  
Naohiro Sekiguchi ◽  
Akihisa Nagata ◽  
Miyuki Wagatsuma ◽  
Kiyoe Midorikawa ◽  
...  
Keyword(s):  
Case Report ◽  
T Cell ◽  
Heavy Chain ◽  
Lymphocytic Leukemia ◽  
Review Of The Literature ◽  
Large Granular Lymphocytic Leukemia ◽  
Heavy Chain Disease

Heavy chain disease

1972 ◽  
Vol 129 (5) ◽  
pp. 836a-837
Author(s):  
B. H. Novis
Keyword(s):  
Heavy Chain ◽  
Heavy Chain Disease

scholarly journals Gamma heavy chain disease: clinical aspects and characterization of a deleted, noncovalently linked gamma1 heavy chain dimer (BAZ)

Blood ◽  
1977 ◽  
Vol 49 (4) ◽  
pp. 495-505 ◽  
Author(s):  
GB Faguet ◽  
BP Barton ◽  
LL Smith ◽  
FA Garver
Keyword(s):  
Heavy Chain ◽  
Plasma Cells ◽  
Clinical Feature ◽  
Clinical Aspects ◽  
Submaxillary Glands ◽  
Underlying Malignancy ◽  
V Region ◽  
Allotypic Marker ◽  
Heavy Chain Disease

Abstract This report describes the clinical and immunoglobulin features of a patient with gamma heavy chain disease (HCD), who presented with a clinical picture suggestive of an underlying malignancy rather than the usual picture of lymphoma or granulomatous disease. A unique clinical feature was the nearly total replacement of the submaxillary glands by plasma cells. The patient's serum and urine contained a paraprotein, gammaHCD protein BAZ, which belongs to the gamma1 subclass and forms noncovalently linked dimers with a molecular weight of approximately 60,000 daltons. This mutant protein exhibited a deletion which encompassed most of the variable (V) region, the first constant domain (CH 1), and the hinge region. In addition, preliminary structural analyses demonstrated the replacement of alanine by glycine in position 431 of the carboxyterminal octadecapeptide. This substitution may possibly represent another allotypic marker on IgG1 proteins.

Heavy-Chain Disease

1968 ◽  
Vol 278 (22) ◽  
pp. 1195-1201 ◽  
Author(s):  
Leonard L. Ellman ◽  
Kurt J. Bloch
Keyword(s):  
Heavy Chain ◽  
Heavy Chain Disease

Follicular Lymphoma With a Burkitt Translocation—Predictor of an Aggressive Clinical Course: A Case Report and Review of the Literature

2004 ◽  
Vol 128 (2) ◽  
pp. 210-213 ◽  
Author(s):  
Peter M. Voorhees ◽  
Kathryn A. Carder ◽  
Scott V. Smith ◽  
Lanier H. Ayscue ◽  
Kathleen W. Rao ◽  
...  
Keyword(s):  
Case Report ◽  
Follicular Lymphoma ◽  
Clinical Course ◽  
Lymphoblastic Leukemia ◽  
Initial Diagnosis ◽  
Indolent Lymphoma ◽  
Review Of The Literature ◽  
Cell Type ◽  
Aberrant Expression ◽  
Aggressive Clinical Course

Abstract Follicular lymphoma is an indolent lymphoma characterized by the (14;18) translocation, which leads to aberrant expression of Bcl-2. Translocations involving 8q24 are most commonly associated with Burkitt lymphoma and result in c-Myc overexpression. We report a case of follicular lymphoma of predominant small cleaved-cell type (grade 1) associated with both a t(14;18)(q32;q21) and a t(8;22)(q24;q11). The 8q24 translocation predicted an aggressive clinical course, as the lymphoma transformed into acute lymphoblastic leukemia within a year of initial diagnosis. Routine cytogenetic analysis is recommended at initial diagnosis of follicular lymphoma to better identify abnormalities that may predict prognosis and influence therapy.

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