scholarly journals Comparison of digoxin concentration in plastic serum tubes with clot activator and heparinized plasma tubes

2014 ◽  
pp. 146-150
Author(s):  
Lora Dukic ◽  
Ana-Maria Simundic ◽  
Davorin Malogorski
Keyword(s):  
Digoxin Concentration ◽  
Clot Activator

The effect of extracorporeal circulation upon the tissue digoxin concentration in the dog

1962 ◽  
Vol 61 (2) ◽  
pp. 281
Author(s):  
Nicholas T. Kouchoukos ◽  
David Goldring ◽  
Robert Main Burton
Keyword(s):  
Extracorporeal Circulation ◽  
Digoxin Concentration

Therapeutic Serum Digoxin Concentration: Relation to Age, Weight, Sex, and Serum Creatinine Levels‡‡

1973 ◽  
Vol 3 (6) ◽  
pp. 606-613 ◽  
Author(s):  
G. J. Schapel ◽  
B. P. McGrath ◽  
K. D. G. Edwards ◽  
M. R. Hawkins ◽  
A. S. Mitchell
Keyword(s):  
Serum Creatinine ◽  
Digoxin Concentration ◽  
Serum Digoxin Concentration ◽  
Serum Digoxin

Effect of Clarithromycin on Steady-State Digoxin Concentrations

2003 ◽  
Vol 37 (2) ◽  
pp. 178-181 ◽  
Author(s):  
Hideko Tanaka ◽  
Kana Matsumoto ◽  
Kazuyuki Ueno ◽  
Mayumi Kodama ◽  
Kohji Yoneda ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Digoxin Concentration ◽  
Concomitant Administration ◽  
Percentage Increase ◽  
P Glycoprotein ◽  
Before And After ◽  
Glycoprotein Inhibitors ◽  
Dose Dependent ◽  
Digoxin Therapy

OBJECTIVE: To evaluate the magnitude and dose-relatedness of the effect of clarithromycin on the pharmacokinetics of digoxin, and to compare the effects of clarithromycin with those of P-glycoprotein inhibitors. METHODS: Eight Japanese inpatients with congestive heart failure participated in this study. Each patient received oral digoxin therapy for at least 7 days and were coadministered oral clarithromycin to prevent or treat pneumonia. To evaluate the effects of clarithromycin on the pharmacokinetics of digoxin, digoxin concentrations were compared before and after coadministration of clarithromycin. RESULTS: Digoxin concentrations were higher after coadministration of clarithromycin in all patients (before, 0.838 ± 0.329 ng/mL; after, 1.36 ± 0.619 ng/mL); (p < 0.005). A significant correlation was observed between the dose of clarithromycin and the percentage of increase in the digoxin concentration. CONCLUSIONS: Digoxin concentrations increased during concomitant administration of clarithromycin, and this effect was dose-dependent on clarithromycin. The percentage increase in digoxin concentrations after the usual oral dose of clarithromycin (400 mg/d) is approximately 70%. Therefore, digoxin concentrations must be monitored carefully after coadministration of clarithromycin, and the doses of digoxin may need readjustment in patients who are concomitantly receiving clarithromycin.

scholarly journals The Concentration of Digoxin Activity after Intravenous in Three Compartments Mathematical Model

2019 ◽  
Vol 8 (2S11) ◽  
pp. 3653-3657
Keyword(s):  
Mathematical Model ◽  
Laplace Transform ◽  
Digoxin Concentration ◽  
Compartment Model ◽  
System Of Equations ◽  
Transfer Coefficients ◽  
Linear Ordinary Differential Equations ◽  
Concentration Time ◽  
The Laplace Transform ◽  
Three Compartment Model

Present paper is designed to compare the distribution of digoxin in three compartment model administered through an intravenous (i.v). These models under consideration is denoted by a system of non-linear ordinary differential equations. The Eigenvalue and the Laplace transform methods were used to solve the system of equations. Digoxin was administered to five subjects through Intravenous then, the serum digoxin concentrations were measured respectively over a period of 72 hours. The transfer coefficients were obtained from observed digoxin concentrations using method of residuals and the variation of digoxin concentration – time curves plotted using MATLAB.

Peak Plasma Digoxin Concentration and Cardiotoxicity

1978 ◽  
pp. 273-283 ◽  
Author(s):  
B. F. Johnson ◽  
D. J. Chapple ◽  
R. Hughes ◽  
J. LaBrooy ◽  
I. Smith
Keyword(s):  
Peak Plasma ◽  
Digoxin Concentration ◽  
Plasma Digoxin ◽  
Plasma Digoxin Concentration

Improved micro-radioimmunoassay of digoxin in serum, with use of 125I-labeled digoxin.

1976 ◽  
Vol 22 (6) ◽  
pp. 903-905 ◽  
Author(s):  
B Calesnick ◽  
A Dinan
Keyword(s):  
Venous Blood ◽  
Digoxin Concentration ◽  
Blood Sampling ◽  
Excellent Correlation ◽  
Accurate Procedure ◽  
Digoxin Therapy

Abstract A micro-radioimmunoassay of 125I-labeled digoxin is described in which 10-mul rather than 50-mul aliquots of sera are required. The method is a modification of a simplified, rapid, and accurate procedure, which is commercially available as a kit. There is excellent correlation between results by these two methods, in which lyophilized digoxin standards and insoluble antibody polymer are used. The digoxin concentration in capillary sera was not significantly different from that in the corresponding venous blood. It is clinically useful to monitor digoxin therapy in capillary sera, particularly in patients in whom blood sampling by venipuncture is inconvenient or difficult.

scholarly journals A comparative evaluation of lithium estimation for samples collected in different tubes and its stability on storage

2018 ◽  
Vol 10 (01) ◽  
pp. 056-059
Author(s):  
Saidaiah Ikkurthi ◽  
Srinivas Balachander ◽  
Bela Goyal ◽  
Altaf Ahmad Mir ◽  
Subho Chakrabarti ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Therapeutic Index ◽  
Blood Collection ◽  
Narrow Therapeutic Index ◽  
Glass Vial ◽  
Reference Collection ◽  
Collection Tube ◽  
Allowable Error ◽  
Bipolar Affective Disorders ◽  
Clot Activator

Abstract PURPOSE: Lithium (Li) is a well-established drug for the treatment of bipolar affective disorders. Li as a drug is known to possess a narrow therapeutic index. Thus, regular monitoring of blood Li in patients receiving Li therapy is essential. Plain tubes with clot activator are known to interfere with Li estimation. The current study was planned to compare Li estimation in sera from vacutainers with clot activator, and plasma from sodium heparinized vacutainers with that of Li estimation in sera from glass vials. The time-dependant stability of Li estimation on storage at 2°C–8°C for 48 h in these three set of tubes was also evaluated. MATERIALS AND METHODS: Blood from the patients on Li therapy (n = 100) was collected in 3 different collection tubes: plain vacutainer with clot activator (S), Sodium heparinized vacutainer (P) and Glass vial (G) and was analyzed by ion selective electrode (ISE) analyzer for Li levels. Secondary aliquots were also taken from each type of collection tube and stored at 2°C–8°C. Time-dependant stability of Li estimation was checked at 12 h, 24 h, and 48 h. ANOVA followed by Tukey's posttest was performed to calculate statistical significance taking glass vial as reference collection tube. Bland–Altman plots were plotted to compare between three collection tubes at baseline. Stability on storage was defined when >95% of the samples were within allowable error limit for that time point taking baseline levels as reference. RESULTS: A mean bias of 0.18 mmol/L and mean percentage bias of 19.9% in Li levels was observed between serum from (S) than serum from (G). This difference was found to be statistically significant. However, statistically nonsignificant mean bias of 0.02 mmol/L and mean percentage bias of 3.34% in Li levels was observed between plasma from (P) and serum from (G). Time-dependant stability was observed more in glass vials as compared to vacutainers with clot activator or sodium heparin. CONCLUSION: Serum from glass vial should be the preferred method for blood collection to determine Li levels.

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