The effects of different syringe volume, needle size and sample volume on blood gas analysis in syringes washed with heparin

Abstract Purpose Delayed cord clamping for at least 60 s is recommended to improve neonatal outcomes. The aim of this study is to evaluate whether there are differences in cord BGA between samples collected after double clamping the cord or without clamping the cord, when blood collection occurs within 60 s from birth in both groups. Methods A cross-sectional study was carried out, collecting data from 6884 high-risk women who were divided into two groups based on the method of cord sampling (clamped vs unclamped). Results There were significant decrease in pH and BE values into unclamped group compared with the clamped group. This difference remained significant when considering pathological blood gas analysis parameters, with a higher percentage of pathological pH or BE values in the unclamped group. Conclusion Samples from the unclamped cord alter the acid–base parameters compared to collection from the clamped cord; however, this difference does not appear to be of clinical relevance. Findings could be due to the large sample size, which allowed to achieve a high power and to investigate very small numerical changes between groups, leading to a statistically significant difference in pH and BE between samples even when we could not appreciate any clinical relevant difference of pH or BE between groups. When blood gas analysis is indicated, the priority should be given to the timing of blood collection to allow reliable results, to assess newborns status at birth and intervene when needed.

Download Full-text

AN IMPROVEMENT IN THE VAN SLYKE METHOD FOR BLOOD GAS ANALYSIS

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)75786-4 ◽

1934 ◽

Vol 104 (1) ◽

pp. 29-31

Author(s):

Friedrich Rappaport ◽

Klara Köck-Molnar

Keyword(s):

Blood Gas Analysis ◽

Gas Analysis ◽

Blood Gas

Download Full-text

Validation of transcutaneous carbon dioxide monitoring using an artificial lung during adult pulsatile cardiopulmonary bypass

The International Journal of Artificial Organs ◽

10.1177/0391398820987855 ◽

2021 ◽

pp. 039139882098785

Author(s):

Lawrence Garrison ◽

Jeffrey B Riley ◽

Steve Wysocki ◽

Jennifer Souai ◽

Hali Julick

Keyword(s):

Carbon Dioxide ◽

Cardiopulmonary Bypass ◽

Gold Standard ◽

Blood Gas Analysis ◽

Gas Analysis ◽

Artificial Lung ◽

Blood Gas ◽

Median Difference ◽

Transcutaneous Carbon Dioxide ◽

Arterial Blood

Measurements of transcutaneous carbon dioxide (tcCO2) have been used in multiple venues, such as during procedures utilizing jet ventilation, hyperbaric oxygen therapy, as well as both the adult and neo-natal ICUs. However, tcCO2 measurements have not been validated under conditions which utilize an artificial lung, such cardiopulmonary bypass (CPB). The purpose of this study was to (1) validate the use of tcCO2 using an artificial lung during CPB and (2) identify a location for the sensor that would optimize estimation of PaCO2 when compared to the gold standard of blood gas analysis. tcCO2 measurements ( N = 185) were collected every 30 min during 54 pulsatile CPB procedures. The agreement/differences between the tcCO2 and the PaCO2 were compared by three sensor locations. Compared to the earlobe or the forehead, the submandibular PtcCO2 values agreed best with the PaCO2 and with a median difference of –.03 mmHg (IQR = 5.4, p < 0.001). The small median difference and acceptable IQR support the validity of the tcCO2 measurement. The multiple linear regression model for predicting the agreement between the submandibular tcCO2 and PaCO2 included the SvO2, the oxygenator gas to blood flow ratio, and the native perfusion index ( R2 = 0.699, df = 1, 60; F = 19.1, p < 0.001). Our experience in utilizing tcCO2 during CPB has demonstrated accuracy in estimating PaCO2 when compared to the gold standard arterial blood gas analysis, even during CO2 flooding of the surgical field.

Download Full-text

A 24‐HOUR BLOOD‐GAS ANALYSIS SERVICE

The Medical Journal of Australia ◽

10.5694/j.1326-5377.1972.tb103679.x ◽

1972 ◽

Vol 2 (18) ◽

pp. 997-999

Author(s):

N. B. Pinkus ◽

B. MacC. Jones ◽

L. W. Faulks

Keyword(s):

Blood Gas Analysis ◽

Gas Analysis ◽

Blood Gas

Download Full-text

StatPal II pH and Blood Gas Analysis System evaluated

Clinical Chemistry ◽

10.1093/clinchem/40.1.124 ◽

1994 ◽

Vol 40 (1) ◽

pp. 124-129 ◽

Cited By ~ 7

Author(s):

R J Wong ◽

J J Mahoney ◽

J A Harvey ◽

A L Van Kessel

Keyword(s):

Point Of Care ◽

Blood Gases ◽

Blood Gas Analysis ◽

Gas Analysis ◽

Portable Instrument ◽

Blood Gas ◽

Target Value ◽

Analysis System

Abstract We evaluated a new portable instrument, the PPG StatPal II pH and Blood Gas Analysis System, designed for "point-of-care" measurements of blood gases and pH. Inaccuracy (% of target value) and imprecision (CV%) were assessed by blood tonometry and comparison with a Corning 178. Within-day results for PCO2 inaccuracy and imprecision ranged from 98.2% to 102.9% and 3.3% to 3.9%, respectively; for PO2, these were 95.5% to 102.3% and 2.3% to 3.0%, respectively. Between-day results for PCO2 inaccuracy and imprecision ranged from 99.2% to 99.3% and from 2.9% to 3.2%, respectively; for PO2, the ranges were 96.2% to 98.2% and 2.6% to 3.0%, respectively. Two PCO2 outliers (in 645 samples = 0.3%) were observed. In general, tonometry recovery, measurement stability, and pH bias results for the StatPal II and Corning 178 were comparable. We conclude that the StatPal II performs within acceptable ranges of inaccuracy and imprecision.

Download Full-text