scholarly journals Relationship between serum interleukin-1β levelsand acute phase response proteins in patients with familial Mediterranean fever

2012 ◽  
pp. 109-113 ◽  
Author(s):  
Kadir Yildrim ◽  
Hulya Uzkeser ◽  
Mustafa Keles ◽  
Saliha Karatay ◽  
Ahmet Kiziltunc ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Phase Response ◽  
Interleukin 1Β ◽  
Mediterranean Fever

Acute phase response and oxidative stress status in familial Mediterranean fever (FMF)

2012 ◽  
Vol 22 (3) ◽  
pp. 431-437 ◽  
Author(s):  
Savas Guzel ◽  
Gulnur Andican ◽  
Arzu Seven ◽  
Mahmure Aslan ◽  
Murat Bolayirli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Familial Mediterranean Fever ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Phase Response ◽  
Oxidative Stress Status ◽  
Mediterranean Fever ◽  
And Oxidative Stress

scholarly journals Familial Mediterranean Fever: Diagnosing as Early as 3 Months of Age

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Gonca Keskindemirci ◽  
Nuray Aktay Ayaz ◽  
Esin Aldemir ◽  
Çiğdem Aydoğmuş ◽  
Gönül Aydoğan ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Autosomal Recessive ◽  
Autosomal Recessive Disease ◽  
Phase Response ◽  
Recurrent Fever ◽  
Ankle Joints ◽  
Mediterranean Fever ◽  
Homozygous Mutations

Familial Mediterranean Fever is an autosomal recessive disease. Major symptoms of disease are recurrent fever accompanied by serositis attacks. The disease is usually diagnosed before 20 years of age. Symptoms related to FMF are noted when children become more verbal, usually after 2 years of age. In this case report, the youngest patient with the diagnosis of FMF is presented. She was consulted to pediatric rheumatology for the high acute phase response and fever. It was learned that her mother had recurrent swelling of her ankle joints. Mutation analysis was performed and two homozygous mutations (M694V and R202Q) were identified. She was diagnosed as FMF at 3 months of age and colchicine was started. She responded to colchicine. Her uncontrolled acute phase response declined gradually. This case was reported to point out the importance of early remembrance of autoinflammatory diseases even at very early ages especially at endemic countries.

scholarly journals Update on the management of colchicine resistant Familial Mediterranean Fever (FMF)

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Georges El Hasbani ◽  
Ali Jawad ◽  
Imad Uthman
Keyword(s):  
Familial Mediterranean Fever ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Autoinflammatory Disease ◽  
Tnf Inhibitors ◽  
Phase Response ◽  
Autoinflammatory Diseases ◽  
Tnf Alpha ◽  
Main Body ◽  
Mediterranean Fever

Abstract Background Familial Mediterranean Fever (FMF), an autoinflammatory disease, is characterized by self-limited inflammatory attacks of fever and polyserositis along with high acute phase response. Although colchicine remains the mainstay in treatment, intolerance and resistance in a certain portion of patients have been posing a problem for physicians. Main body Like many autoimmune and autoinflammatory diseases, many colchicine-resistant or intolerant FMF cases have been successfully treated with biologics. In addition, many studies have tested the efficacy of biologics in treating FMF manifestations. Conclusion Since carriers of FMF show significantly elevated levels of serum TNF alpha, IL-1, and IL-6, FMF patients who failed colchicine were successfully treated with anti IL-1, anti IL-6, or TNF inhibitors drugs. It is best to use colchicine in combination with biologics.

Follistatin concentrations in male sheep increase following sham castration/castration or injection of interleukin-1β

1996 ◽  
Vol 151 (1) ◽  
pp. 119-124 ◽  
Author(s):  
D J Phillips ◽  
M P Hedger ◽  
J R McFarlane ◽  
R Klein ◽  
I J Clarke ◽  
...  
Keyword(s):  
Acute Phase ◽  
Acute Phase Response ◽  
Interleukin 2 ◽  
Inhibitory Effect ◽  
Phase Response ◽  
Interleukin 1Β ◽  
Tnf Α ◽  
Recombinant Interleukin 2 ◽  
Factor Α ◽  
Male Sheep

Abstract Plasma follistatin (FS) concentrations were determined after castration (n=5) or sham castration (n=4) of mature rams. Both treatments resulted in a prolonged increase in FS between 7 and 19 h after surgery, which returned to pretreatment concentrations by 24 h. Tumour necrosis factor-α (TNF-α), a sensitive marker of an acute-phase response, was undetectable in plasma, indicating that the FS response was not induced by trauma due to surgery. In a second experiment, injection of castrated rams (n=4) with ovine recombinant interleukin-1β, an acute-phase mediator, resulted in a sustained rise in FS concentrations within 4 h of injection. Plasma TNF-α concentrations increased transiently within 1 h of interleukin-1β injection, indicating that an acute-phase response had been initiated. Plasma follicle-stimulating hormone (FSH) concentrations were significantly decreased at 8 and 24 h after interleukin-1β injection, strongly suggestive of an inhibitory effect of increased FS concentrations on the secretion of FSH. Injection of castrated rams (n=2) with a control preparation of recombinant interleukin-2 did not induce an acute-phase response, and plasma FS and FSH concentrations were unaffected. These data show that the testis is not a major source of circulating FS, that the increase in circulating FS following sham castration/castration is not due to an acute-phase response, but that conversely FS concentrations are modulated by the acute-phase mediator, interleukin-1β. Journal of Endocrinology (1996) 151, 119–124

scholarly journals Resistance to fever induction and impaired acute-phase response in interleukin-1β-deficient mice

Immunity ◽  
1995 ◽  
Vol 3 (1) ◽  
pp. 9-19 ◽  
Author(s):  
Hui Zheng ◽  
Daniel Fletcher ◽  
Wieslaw Kozak ◽  
Minghao Jiang ◽  
Kathryn J. Hofmann ◽  
...  
Keyword(s):  
Acute Phase ◽  
Acute Phase Response ◽  
Phase Response ◽  
Interleukin 1Β ◽  
Deficient Mice
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