scholarly journals Target Practice: Aiming for Automated Perfusion in Childhood Stroke

Stroke ◽  
2021 ◽  
Author(s):  
Sarah Lee ◽  
Catherine M. Amlie-Lefond
Keyword(s):  
Childhood Stroke

Symptom patterns in childhood arterial ischemic stroke: Analysis of a population-based study in Germany

2018 ◽  
Vol 230 (06) ◽  
pp. 319-325
Author(s):  
Lucia Gerstl ◽  
Raphael Weinberger ◽  
Rüdiger von Kries ◽  
Florian Heinen ◽  
Andreas Sebastian Schroeder ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Clinical Symptoms ◽  
Population Based ◽  
Case Definition ◽  
Childhood Stroke ◽  
Older Children ◽  
Arterial Ischemic Stroke ◽  
Focal Neurological Deficit ◽  
Symptom Patterns ◽  
Specific Symptoms

Hintergrund Die zeitliche Verzögerung zwischen Symptombeginn und Diagnose ist eine Herausforderung in der Behandlung von Kindern mit arteriell ischämischem Schlaganfall. Frühere Studien zur klinischen Präsentation beschäftigten sich v. a. mit kumulativen Symptomen. Zielsetzung Ziel dieser Studie ist es, mögliche Symptommuster aufzuzeigen. Methoden In einer aktiven Beobachtungsstudie zwischen 01/2015 und 12/2016 (ESPED-Studie) wurden Kinder mit Erstdiagnose eines arteriell ischämischen Schlaganfalls eingeschlossen. Isoliert auftretende Erstsymptome wurden verschiedenen Symptomkombinationen gegenübergestellt. Zudem wurde untersucht, inwieweit ein als „akut“ oder „progredient“ klassifiziertes Auftreten der Symptome Rückschlüsse auf die zugrundeliegende Ätiologie erlaubt. Ergebnisse Es wurden 99 Kinder in die Studie eingeschlossen. Unabhängig vom Alter traten überwiegend fokale Symptome auf (86%). Krampfanfälle als Initialsymptom wurden insbesondere bei Säuglingen beschrieben (67%), wohin-gegen diffuse, unspezifische Symptome vor allem bei Vorschulkindern (38%) und älteren Kindern (59%) auftraten. Isoliert traten fokale Symptome bei 37 Kindern auf, 48 Kinder zeigten zusätzlich unspezifische Symptome, darunter auch 9 Kinder mit Krampfanfällen. Isolierte unspezifische Symptome zeigten sich lediglich bei 7 Kindern, 2 Kinder wurden nur mit Krampfanfällen symptomatisch. Die Akuität des Symptombeginns wurde bei 53/78 als „akut“ und bei “25/78 Fällen als „progredient“ klassifiziert, lieferte jedoch keinen Hinweis auf die zugrundeliegende Ätiologie. Schlussfolgerung Jedes neue fokal neurologische Defizit sollte unabhängig vom Auftreten (isoliert oder kombiniert, akut oder progredient) an einen kindlichen Schlaganfall denken lassen. Background Time delay between onset of clinical symptoms and diagnosis is a challenge in childhood arterial ischemic stroke. Most previous studies reported cumulative symptoms. Objective We attempted to identify typical symptom patterns and assessed their emergence in childhood stroke. Methods Prospective active surveillance in ESPED, a hospital based Pediatric Surveillance Unit for rare diseases in Germany, between January 2015 and December 2016. Case definition: first diagnosis of a radiologically confirmed arterial ischemic stroke. Symptom patterns were identified as occurring in isolation or in combination. We distinguished acute vs. progressive onset. We ascertained risk factors to identify the possible etiology. Results 99 children with childhood arterial ischemic stroke were reported. Focal symptoms were the predominant presenting feature (86%), independent of age. Seizures were more often seen in infants < 1 year (67%), whereas diffuse symptoms were more present in pre-school children (38%) and older children (59%). 37 children had focal features alone and 48 additional non-specific features, including 9 with seizures. Isolated non-specific features accounted for 7 cases, and 2 children had (focal) seizures as the only symptom. In 77% of all cases at least one risk factor was identified. The emergence of symptoms was acute in 53/78 cases and progressive in 25/78 cases. The pattern of emergence was unrelated to the underlying etiology. Conclusions Any new focal neurological deficit in isolation, or associated with seizures or further non-specific symptoms should alert to childhood stroke.

scholarly journals Functional, cognitive and school outcomes after childhood stroke

2014 ◽  
Vol 57 ◽  
pp. e19
Author(s):  
E. Yvon Chaou ◽  
D. Lamotte ◽  
A. Tiberghien ◽  
A. Mardaye ◽  
M. De Agostini ◽  
...  
Keyword(s):  
School Outcomes ◽  
Childhood Stroke

Childhood Stroke

2013 ◽  
pp. 392-392
Author(s):  
Satinder Aneja
Keyword(s):  
Childhood Stroke

MR Imaging Diagnosis of ACTA2

Neurographics ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 409-413
Author(s):  
R. Farias-Moeller ◽  
S.M. Lew ◽  
R. Sacho ◽  
T.G. Kelly
Keyword(s):  
Smooth Muscle ◽  
Clinical Manifestations ◽  
Muscle Dysfunction ◽  
Imaging Features ◽  
Imaging Diagnosis ◽  
Childhood Stroke ◽  
Intestinal Dysmotility ◽  
Prognostic Implications ◽  
Smooth Muscle Dysfunction ◽  
Large Vessel Disease

Smooth muscle alpha-2 actin (ACTA2) mutations are associated with diffuse smooth-muscle dysfunction syndrome and produce distinct imaging features. Clinical manifestations include intrathoracic large-vessel disease, nonreactive mydriasis, bladder hypotonia, and intestinal dysmotility. ACTA2 mutations are associated with childhood stroke due to diffuse cerebral arteriopathy distinct from moyamoya disease. Recognition of this syndrome has important clinical and prognostic implications. The purpose of this article is to review the unique imaging phenotypes associated with ACTA2 mutations, including vascular and nonvascular abnormalities.

Pediatric Stroke Impairs Theory of Mind Performance

2019 ◽  
Vol 35 (3) ◽  
pp. 228-234
Author(s):  
Warren Lo ◽  
Xiangrui Li ◽  
Kristen Hoskinson ◽  
Kelly McNally ◽  
Melissa Chung ◽  
...  
Keyword(s):  
Social Cognition ◽  
Theory Of Mind ◽  
Resting State ◽  
Network Connectivity ◽  
Brain Regions ◽  
Childhood Stroke ◽  
Magnetic Resonance Imaging Mri ◽  
And Gender ◽  
Resting State Connectivity ◽  
Control Study

Aim: This pilot study explored whether childhood stroke impairs performance on theory of mind (ToM) tasks and whether ToM task performance correlates with resting state connectivity in brain regions linked with social cognition. Method: We performed a case-control study of 10 children with stroke and 10 age- and gender-matched controls. They completed 2 ToM tasks, and resting state connectivity was measured with functional magnetic resonance imaging (MRI). Results: Children with stroke performed worse than controls on conative ToM tasks. Resting state connectivity in the central executive network was significantly higher and connectivity between right and left inferior parietal lobules was significantly decreased in children with stroke. Resting state activity and ToM performance were not significantly correlated. Interpretation: Childhood stroke results in poorer performance on specific ToM tasks. Stroke is associated with changes in resting state connectivity in networks linked with social cognition including ToM. Although the basis for these changes in connectivity is not well understood, these results may provide preliminary insights into potential mechanisms affecting social cognition after stroke. The findings suggest that further study of the effect of childhood stroke on network connectivity may yield insights as to how stroke affects cognitive functions in children.

Focal cerebral arteriopathy and childhood stroke

2020 ◽  
Vol 33 (1) ◽  
pp. 37-46 ◽  
Author(s):  
Nicola D. Fearn ◽  
Mark T. Mackay
Keyword(s):  
Childhood Stroke ◽  
Cerebral Arteriopathy
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