scholarly journals Response by Aparicio et al to Letter Regarding Article, “Temporal Trends in Ischemic Stroke Incidence in Younger Adults in the Framingham Study”

Stroke ◽  
2019 ◽  
Vol 50 (12) ◽  
Author(s):  
Hugo J. Aparicio ◽  
Alexa S. Beiser ◽  
Sudha Seshadri
Keyword(s):  
Ischemic Stroke ◽  
Temporal Trends ◽  
Framingham Study ◽  
Younger Adults ◽  
Stroke Incidence

scholarly journals Temporal Trends in Ischemic Stroke Incidence in Younger Adults in the Framingham Study

Stroke ◽  
2019 ◽  
Vol 50 (6) ◽  
pp. 1558-1560 ◽  
Author(s):  
Hugo J. Aparicio ◽  
Jayandra J. Himali ◽  
Claudia L. Satizabal ◽  
Matthew P. Pase ◽  
Jose R. Romero ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Temporal Trends ◽  
Framingham Study ◽  
Younger Adults ◽  
Stroke Incidence

Abstract WP408: Temporal Trends in Pediatric Stroke Hospitalization From 2000 - 2009: Analysis of the KID Inpatient Database

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
John M Taylor ◽  
Paul Horn ◽  
Samrat Yeramaneni ◽  
Heidi Sucharew ◽  
Jane Khoury
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Temporal Trends ◽  
Public Health Problem ◽  
Pediatric Stroke ◽  
Hospitalized Children ◽  
Important Public Health Problem ◽  
Stroke Incidence ◽  
Number Of Discharges ◽  
Inpatient Database

Background/Hypothesis: Stroke in children ≤18 years is an important public health problem. The incidence of stroke in adults has been falling over several decades, likely attributable to better management of vascular risk factors. Children have different risk factors for cerebrovascular disease, however we wanted to see if similar trends were observed in pediatric stroke. We examined pediatric hospital discharges for stroke over the last decade. Methods: We used the Kids’ Inpatient Database (KID) for 2000, 2003, 2006, and 2009 using the published weighting guidelines to estimate the number of overall discharges and number of discharges due to stroke. To identify stroke we queried primary position discharge ICD-9 stroke codes 430, 431, 432.9, 434.X1, 434.9, and 435.9; previously identified to have high PPV for detection of stroke in children in a physician-verified epidemiology stroke study. We calculated incidence for stroke among hospitalized children as number of stroke discharges / total number of discharges, and expressed the ratio per 100,000 discharges. We compared trends in stroke type, age, race and sex over the decade. Results: Stroke incidence in 2000 was 26.4 (95% CI 23.2-29.6). In the 2009 sample, incidence was 30.9 (27.7-34.1) showing a non-significant increasing trend over time. Ischemic stroke was increasingly diagnosed over the same interval with a statistically significantly higher incidence in 2006 and 2009 compared to 2000 (Figure 1). Groups with highest stroke incidence in hospitalized children were 10-14 year olds, males, and children identifying with the racial group “black.” Conclusion: In the KID database, we identified a rising incidence of ischemic stroke diagnosis over the past decade, however the overall rate of pediatric stroke has not increased significantly. The increasing rate of an ischemic stroke discharge diagnosis may be the result of increased awareness of childhood stroke.

Nationwide Trends in Incidence and Mortality of Stroke Among Younger and Older Adults in Denmark

Neurology ◽  
2021 ◽  
Vol 96 (13) ◽  
pp. e1711-e1723
Author(s):  
Nils Skajaa ◽  
Kasper Adelborg ◽  
Erzsébet Horváth-Puhó ◽  
Kenneth J. Rothman ◽  
Victor W. Henderson ◽  
...  
Keyword(s):  
Older Adults ◽  
Ischemic Stroke ◽  
Subarachnoid Hemorrhage ◽  
Intracerebral Hemorrhage ◽  
Temporal Trends ◽  
Age Groups ◽  
Stroke Mortality ◽  
Younger Adults ◽  
Incidence And Mortality ◽  
First Time

ObjectiveTo investigate the extent to which the incidence and mortality of a first-time stroke among younger and older adults changed from 2005 to 2018 in Denmark using nationwide registries.MethodsWe used the Danish Stroke Registry and the Danish National Patient Registry to identify patients 18 to 49 years of age (younger adults) and those ≥50 years of age (older adults) with a first-time ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. We computed age-standardized incidence rates and 30-day and 1-year mortality risks separately for younger and older adults and according to smaller age groups, stroke subtype, sex, and severity (Scandinavian Stroke Scale score). Average annual percentage changes (AAPCs) were computed to assess temporal trends.ResultsWe identified 8,680 younger adults and 105,240 older adults with an ischemic stroke or intracerebral hemorrhage. The incidence rate per 100,000 person-years of ischemic stroke (20.8 in 2005 and 21.9 in 2018, AAPC −0.6 [95% confidence interval (CI) −1.5 to 0.3]) and intracerebral hemorrhage (2.2 in 2005 and 2.5 in 2018, AAPC 0.6 [95% CI −1.0 to 2.3]) remained steady in younger adults. In older adults, rates of ischemic stroke and intracerebral hemorrhage declined, particularly in those ≥70 years of age. Rates of subarachnoid hemorrhage declined, but more so in younger than older adults. Stroke mortality declined over time in both age groups, attributable largely to declines in the mortality after severe strokes. Most trends were similar for men and women.ConclusionThe incidence of ischemic stroke and intracerebral hemorrhage was steady in younger adults from 2005 to 2018, while it dropped in adults >70 years of age. Stroke mortality declined during this time.

Temporal Trends in the Incidence of Ischemic Stroke in Young Adults: Dijon Stroke Registry

2021 ◽  
pp. 1-6
Author(s):  
Yannick Béjot ◽  
Gauthier Duloquin ◽  
Quentin Thomas ◽  
Sophie Mohr ◽  
Lucie Garnier ◽  
...  
Keyword(s):  
Young Adults ◽  
Sex Differences ◽  
Ischemic Stroke ◽  
Temporal Trends ◽  
Population Based ◽  
Incidence Rates ◽  
Stroke Incidence ◽  
Stroke Registry ◽  
Stroke In Young Adults ◽  
Stroke In Young

<b><i>Introduction:</i></b> Stroke is associated with major consequences in terms of socioeconomic impact and lost disability-adjusted life in young victims, thus justifying a careful surveillance of epidemiological trends. This study aimed to assess changes in the incidence of ischemic stroke in young adults over a long period. <b><i>Methods:</i></b> All cases of first-ever ischemic stroke that occurred among adults aged 18–55 years were prospectively recorded using the population-based Dijon Stroke Registry, from 1985 to 2017. Sex-specific annual incidence rates were calculated and were presented according to 6 time periods. Incidence rate ratios (IRRs) were determined to assess sex differences in stroke incidence. <b><i>Results:</i></b> Over the whole study period, 4,451 patients suffered a first-ever ischemic stroke. Among these patients, 469 (10.5%) were young adults (median age: 46 years, IQR: 39–50; 53.9% men). Incidence rates rose from the study period 2003 to 2007 compared with previous periods and remained stable thereafter, both in men and women. Hence, incidence per 100,000 per year was globally 11.0 (95% CI: 9.4–12.7) before 2003 and 22.9 (20.3–25.6) thereafter. In individuals aged 18–45 years, incidence rates were 5.4 (4.3–6.9) overall, 4.1 (2.7–6.0) in men, and 6.7 (4.9–9.0) in women, before 2003. After 2003, incidence rates rose to 12.8 (10.7–15.1) overall, 12.0 (9.2–15.4) in men, and 13.6 (10.6–17.0) in women. In this age group, the men/women IRR was 0.78 (95% CI: 0.62–1.26, <i>p</i> = 0.08), although sex differences decreased over time (IRR = 0.62; 95% CI: 0.36–1.02, <i>p</i> = 0.046 before 2003, vs. IRR = 0.88; 95% CI: 0.62–1.26, <i>p</i> = 0.48 after 2003). In individuals aged 45–55 years, incidence rates before 2003 were 47 (37–61) in men and 25 (17–35) in women (IRR = 1.90; 95% CI: 1.24–2.97, <i>p</i> &#x3c; 0.001), and they increased to 82 (67–100) in men and 46 (35–59) in women (IRR = 1.79; 95% CI: 1.29–2.49, <i>p</i> &#x3c; 0.001) after 2003. <b><i>Conclusions:</i></b> The incidence of ischemic stroke in young adults increased during the early 2000s and remained stable thereafter. These results highlight the priority need for dedicated prevention strategies for the young to reduce the burden of stroke.

Temporal Trends in Ischemic Stroke Rates by Ethnicity, Sex, and Age 2000–2017: The Brain Attack Surveillance in Corpus Christi Project

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000012877
Author(s):  
Lynda D. Lisabeth ◽  
Devin L. Brown ◽  
Darin B. Zahuranec ◽  
Sehee Kim ◽  
Jaewon Lim ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Mexican Americans ◽  
Temporal Trends ◽  
Age Groups ◽  
Population Based ◽  
Relative Increase ◽  
Stroke Incidence ◽  
Corpus Christi ◽  
Time Interaction ◽  
Diagnosis Codes

Objective:To compare 18-year (2000-2017) temporal trends in ischemic stroke rates by ethnicity, sex and age.Methods:Data are from a population-based stroke surveillance study conducted in Nueces County, Texas, USA, a geographically isolated, bi-ethnic, urban community. Active (screening hospital admission logs, hospital wards, intensive care units) and passive (screening inpatient/ED discharge diagnosis codes) surveillance were used to identify cases aged ≥45 (n=4,874) validated by stroke physicians using a consistent stroke definition over time. Ischemic stroke rates were derived from Poisson regression using annual population counts from US Census to estimate at-risk population.Results:In those aged 45-59, rates increased in non-Hispanic Whites (104.3% relative increase; p<0.001) but decreased in Mexican Americans (-21.9%; p=0.03) such that rates were significantly higher in non-Hispanic Whites in 2016-2017 (p for ethnicity-time interaction<0.001). In those age 60-74, rates declined in both groups but more so in Mexican Americans (non-Hispanic Whites -18.2%, p=0.05; Mexican Americans -40.1%, p=0.002) resulting in similar rates for the two groups in 2016-2017 (p for ethnicity-time interaction=0.06). In those aged ≥75, trends did not vary by ethnicity, with declines noted in both groups (non-Hispanic Whites -33.7%, p=0.002; Mexican Americans -26.9%, p=0.02). Decreases in rates were observed in men (age 60-74 -25.7%, p=0.009; age ≥75 -39.2% p=0.002) and women (age 60-74 -34.3%, p=0.007; age ≥75 -24.0% p=0.02) in the two older age groups, while rates did not change in either sex in those age 45-59.Interpretation:Previously documented ethnic stroke incidence disparities have ended as a result of declining rates in Mexican Americans and increasing rates in non-Hispanic whites, most notably in midlife.

scholarly journals Impact of COVID-19 on Future Ischemic Stroke Incidence

2021 ◽  
Vol 22 ◽  
pp. 100325
Author(s):  
Aisha Elfasi ◽  
Franklin D. Echevarria ◽  
Robert Rodriguez ◽  
Yoram A. Roman Casul ◽  
Anna Yuzefovich Khanna ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Stroke Incidence

scholarly journals Disparities in the Use of Intravenous t-PA among Ischemic Stroke Patients: Population-based Recent Temporal Trends

2019 ◽  
Vol 28 (5) ◽  
pp. 1243-1251 ◽  
Author(s):  
Mohammad A. Faysel ◽  
Jonathan Singer ◽  
Caroline Cummings ◽  
Dimitre G. Stefanov ◽  
Steven R. Levine
Keyword(s):  
Ischemic Stroke ◽  
Temporal Trends ◽  
Population Based ◽  
Stroke Patients
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