scholarly journals Response by Castonguay et al to Letter Regarding Article “Intraarterial Thrombolysis as Rescue Therapy for Large Vessel Occlusions”

Stroke ◽  
2019 ◽  
Vol 50 (7) ◽  
Author(s):  
Alicia C. Castonguay ◽  
Mouhammad A. Jumaa ◽  
Syed F. Zaidi
Keyword(s):  
Rescue Therapy ◽  
Large Vessel ◽  
Intraarterial Thrombolysis

scholarly journals Intraarterial Thrombolysis as Rescue Therapy for Large Vessel Occlusions

Stroke ◽  
2019 ◽  
Vol 50 (4) ◽  
pp. 1003-1006 ◽  
Author(s):  
Syed F. Zaidi ◽  
Alicia C. Castonguay ◽  
Mouhammad A. Jumaa ◽  
Tim W. Malisch ◽  
Italo Linfante ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Stroke ◽  
Acute Ischemic Stroke ◽  
Rescue Therapy ◽  
Stent Retriever ◽  
Large Vessel ◽  
Stroke Patients ◽  
Stroke Registry ◽  
The North ◽  
Intraarterial Thrombolysis

Background and Purpose— Mechanical thrombectomy (MT) devices have led to improved reperfusion and clinical outcomes in acute ischemic stroke patients with emergent large vessel occlusions; however, less than one-third of patients achieve complete reperfusion. Use of intraarterial thrombolysis in the context of MT may provide an opportunity to enhance these results. Here, we evaluate the use of intraarterial rtPA (recombinant tissue-type plasminogen activator) as rescue therapy (RT) after failed MT in the North American Solitaire Stent-Retriever Acute Stroke registry. Methods— The North American Solitaire Stent-Retriever Acute Stroke registry recruited sites within North America to submit data on acute ischemic stroke patients treated with the Solitaire device. After restricting the population of 354 patients to use of RT and anterior emergent large vessel occlusions, we compared patients who were treated with and without intraarterial rtPA after failed MT. Results— A total of 37 and 44 patients was in the intraarterial rtPA RT and the no intraarterial rtPA RT groups, respectively. Revascularization success (modified Thrombolysis in Cerebral Infarction ≥2b) was achieved in more intraarterial rtPA RT patients (61.2% versus 46.6%; P =0.13) with faster times to recanalization (100±85 versus 164±235 minutes; P =0.36) but was not statistically significant. The rate of symptomatic intracranial hemorrhage (13.9% versus 6.8%; P =0.29) and mortality (42.9% versus 44.7%; P =0.87) were similar between the groups. Good functional outcome (modified Rankin Scale score of ≤2) was numerically higher in intraarterial rtPA patients (22.9% versus 18.4%; P =0.64). Further restriction of the RT population to M1 occlusions only and time of onset to groin puncture ≤8 hours, resulted in significantly higher successful revascularization rates in the intraarterial rtPA RT cohort (77.8% versus 38.9%; P =0.02). Conclusions— Intraarterial rtPA as RT demonstrated a similar safety and clinical outcome profile, with higher reperfusion rates achieved in patients with M1 occlusions. Prospective studies are needed to delineate the role of intraarterial thrombolysis in MT.

SOFIA catheter for direct aspiration of large vessel occlusion stroke: A single-center cohort and meta-analysis

2021 ◽  
pp. 159101992110053
Author(s):  
Federico Bolognini ◽  
Pablo A Lebedinsky ◽  
Mariano Musacchio ◽  
Mariette Delaitre ◽  
Abdoulaye M Traoré ◽  
...  
Keyword(s):  
Rescue Therapy ◽  
Meta Analysis ◽  
Functional Independence ◽  
Large Vessel ◽  
Study Cohort ◽  
Large Vessel Occlusion ◽  
First Line ◽  
Vessel Occlusion ◽  
Global Rate ◽  
Symptomatic Intracranial Hemorrhage

Background and Purpose Direct aspiration (DA) using large-bore distal aspiration catheters is an established strategy for the endovascular thrombectomy (EVT) of large-vessel occlusion stroke (LVOS). However, the performance of individual catheters like SOFIA has yet to be examined. Methods We present a cohort of 144 consecutive patients treated with first-line DA and SOFIA 6 F Plus catheter for LVOS. We also conducted a systematic review of the literature searching multiple databases for reports on thrombectomy with DA and SOFIA catheters and performed a meta-analysis of recanalization, safety, and clinical outcomes. Results In the study cohort a successful recanalization (mTICI 2b-3) rate of 75.7% was achieved with DA alone, the global rate for functional independence (90-day mRS 0-2) was 40.3%. For the metanalysis we selected nine articles that included a total of 758 patients treated with first-line thrombectomy with the SOFIA catheters. The mTICI 2b-3 rate was 71.6% (95%CI, 66.3-76.5%) while a rescue stent-retriever was used in 24.1% (95%CI, 17.7-31.9%) of cases. The overall mTICI2b-3 rate after DA and rescue therapy was 88.9% (95%CI, 82.6-93.1%). We found a pooled estimate of 45.6% (95%CI, 38.6-52.8%) for functional independence, a mortality within 90 days of 19% (95%CI, 14.1-25.0%) and a rate of 5.8% (95%CI, 4.2-8.0%) of symptomatic intracranial hemorrhage. Conclusion The DA approach for LVOS with the SOFIA catheters is highly effective with an efficacy and safety profile comparable to those found in contemporary thrombectomy trials and observational studies that use other devices or approaches.

Comparison of aspiration-first versus stentriever-first techniques in performing mechanical thrombectomy for large vessel occlusions

2020 ◽  
pp. neurintsurg-2020-016547
Author(s):  
Vance L Fredrickson ◽  
Phillip A Bonney ◽  
Shivani D Rangwala ◽  
Joshua S Catapano ◽  
Tyler S Cole ◽  
...  
Keyword(s):  
Retrospective Cohort ◽  
Mechanical Thrombectomy ◽  
Rescue Therapy ◽  
Multivariable Analysis ◽  
Large Vessel ◽  
Aspiration Thrombectomy ◽  
Patient Demographics ◽  
Radiographic Outcomes ◽  
Operator Series ◽  
First Pass

BackgroundBoth stentriever and direct-aspiration thrombectomy effectively treat large-vessel occlusions. However, data are limited comparing clinical outcomes after aspiration-first versus stentriever-assisted aspiration for thrombectomy.MethodsA retrospective cohort study compared procedure times and radiographic outcomes after two mechanical thrombectomy techniques (aspiration first or stentriever). To minimize bias and variability inherent to multi-operator series, we assessed consecutive patients with cerebrovascular occlusions treated by a single surgeon during a 1 year period at two stroke centers. Expanded Thrombolysis in Cerebral Infarction (eTICI) grades were assessed by an investigator blinded to treatment.ResultsData from 93 patients (median age 70 years) were analyzed: 73 patients (78.5%) were treated with a strentriever-first strategy and 20 (21.5%) were treated with aspiration first, with stentriever rescue therapy required in only three of these cases following unsuccessful aspiration. There were no significant differences in patient demographics, sites of occlusion, or rates of tandem occlusions between aspiration-first and stentriever-assisted groups (p≥0.36). The rate of first-pass eTICI ≥2b was 75.0% (15/20) for aspiration-first and 52.1% (38/73) for strentriever-first groups (p=0.07), while the rate of final eTICI ≥2b was 100% (20/20) and 82.2% (60/72), respectively (p=0.04). The aspiration-first technique was associated with procedural times ≤25 min in a multivariable analysis (adjusted OR 4.77, 95% CI 1.15 to 18.39; p=0.03).ConclusionsIn this single-surgeon series, an aspiration-first technique was associated with a statistically significant improvement in eTICI outcomes and faster procedure times compared with stentriever-assisted aspiration. Further prospective studies are necessary to minimize selection bias inherent in this study design.

scholarly journals Outcomes of Rescue Endovascular Treatment of Emergent Large Vessel Occlusion in Patients With Underlying Intracranial Atherosclerosis: Insights From STAR

2021 ◽  
Author(s):  
Sami Al Kasab ◽  
Eyad Almallouhi ◽  
Ali Alawieh ◽  
Stacey Wolfe ◽  
Kyle M. Fargen ◽  
...  
Keyword(s):  
Balloon Angioplasty ◽  
Rescue Therapy ◽  
Hemorrhagic Transformation ◽  
Large Vessel ◽  
Intracranial Atherosclerosis ◽  
Vessel Occlusion ◽  
Procedural Time ◽  
The Difference ◽  
And Control

Background Some emergent large vessel occlusions (ELVOs) are refractory to reperfusion because of underlying intracranial atherosclerosis (ICAS), often requiring rescue therapy (RT) with balloon angioplasty, stenting, or both. In this study, we investigate the safety, efficacy, and long‐term outcomes of RT in the setting of mechanical thrombectomy for ICAS‐related ELVO. Methods and Results We queried the databases of 10 thrombectomy‐capable centers in North America and Europe included in STAR (Stroke Thrombectomy and Aneurysm Registry). Patients with ELVO who underwent ICAS‐related RT were included. A matched sample was produced for variables of age, admission National Institute of Health Stroke Scale, Alberta Stroke Program Early CT Score, onset to groin puncture time, occlusion site, and final recanalization. Out of 3025 patients with MT, 182 (6%) patients required RT because of underlying ICAS. Balloon angioplasty was performed on 122 patients, and 117 patients had intracranial stenting. In the matched analysis, 141 patients who received RT matched to a similar number of controls. The number of thrombectomy passes was higher (3 versus 1, P <0.001), and procedural time was longer in the RT group (52 minutes versus 36 minutes, P =0.004). There was a higher rate of symptomatic hemorrhagic transformation in the RT group (7.8% versus 4.3%, P =0.211), however, the difference was not significant. There was no difference in 90‐day modified Rankin scale of 0 to 2 (44% versus 47.5%, P =0.543) between patients in the RT and control groups. Conclusions In patients with ELVO with underlying ICAS requiring RT, despite longer procedure time and a more thrombectomy passes, the 90 days favorable outcomes were comparable with patients with embolic ELVO.

Abstract 130: Outcomes of Rescue Endovascular Treatment of Acute Ischemic Stroke in Patients With Underlying Intracranial Atherosclerosis- Insights From the STAR Registry

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Sami Al Kasab ◽  
Eyad Almallouhi ◽  
Michael A Casey ◽  
Ali Alawieh ◽  
Reda M Chalhoub ◽  
...  
Keyword(s):  
Balloon Angioplasty ◽  
Rescue Therapy ◽  
Large Vessel ◽  
Complication Rates ◽  
Intracranial Atherosclerosis ◽  
Large Vessel Occlusion ◽  
Vessel Occlusion ◽  
Long Term Outcome ◽  
Procedural Time

Introduction: Mechanical Thrombectomy (MT) is currently the standard of care for patients presenting with emergent large vessel occlusion (ELVO) with salvageable tissue. A subgroup of patients with ELVO are found to have refractory occlusion due to underlying intracranial atherosclerosis (ICAS), often requiring angioplasty with or without stenting. Whether this treatment is safe or effective in this group of patients remains to be established. The purpose of this study is to investigate the safety, efficacy and long-term outcome of MT with rescue therapy in patients with ICAS. Methods: STAR registry combined prospectively maintained databases of 11 thrombectomy-capable centers in the US, Europe and Asia. In this analysis, we included patients who underwent rescue balloon angioplasty and/or stenting in the setting of ELVO. A matched sample was produced by matching on the variables of age, admission NIHSS, and location of occlusion. Results: Out of 2827 thrombectomy patients included in STAR registry, 190 patients received MT and required rescue angioplasty and/or stenting. Balloon angioplasty was performed on 116 patients, and 84 patients had intracranial stenting. Compared to the 161 ICAS patients matched to similar number of controls. There was no difference in age, race, sex, rate of IV tPA administration, ASPECTS score, or onset to groin time. Successful first attempt was higher in patients with embolic LVO (22 vs 52, p=0.001), procedural time was longer in patients with ICAS (47 min Vs 31 min, p=<0.001). There was no difference in symptomatic intracranial hemorrhage, or long term functional outcome. Conclusion: In patients with ELVO with underlying ICAS requiring rescue angioplasty and/or stenting; despite longer procedural time and lower rate of first pass revascularization, rescue therapy appears to be safe with similar complication rates and long-term functional outcomes compared to patients with large vessel occlusion from embolic source. Table 1:

The Chemical Optimization of Cerebral Embolectomy trial: Study protocol

2019 ◽  
pp. 174749301989565 ◽  
Author(s):  
Arturo Renú ◽  
Jordi Blasco ◽  
Mónica Millán ◽  
Joan Martí-Fàbregas ◽  
Pere Cardona ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Sample Size ◽  
Primary Outcome ◽  
Mechanical Thrombectomy ◽  
Large Vessel ◽  
Modified Rankin Scale ◽  
Large Vessel Occlusion ◽  
Vessel Occlusion ◽  
Intraarterial Thrombolysis ◽  
Infarct Expansion

Rationale The potential value of rescue intraarterial thrombolysis in patients with large vessel occlusion stroke treated with mechanical thrombectomy has not been assessed in randomized trials. Aim The CHemical OptImization of Cerebral Embolectomy trial aims to establish whether rescue intraarterial thrombolysis is more effective than placebo in improving suboptimal reperfusion scores in patients with large vessel occlusion stroke treated with mechanical thrombectomy. Sample size estimates A sample size of 200 patients allocated 1:1 to intraarterial thrombolysis or intraarterial placebo will have >95% statistical power for achieving the primary outcome (5% in the control versus 60% in the treatment group) for a two-sided (5% alpha, and 5% lost to follow-up). Methods and design We conducted a multicenter, randomized, placebo-controlled, double blind, phase 2b trial. Eligible patients are 18 or older with symptomatic large vessel occlusion treated with mechanical thrombectomy resulting in a modified treatment in cerebral ischemia score 2b at end of the procedure. Patients will receive 20–30 min intraarterial infusion of recombinant tissue plasminogen activator or placebo (0.5 mg/ml, maximum dose limit 22.5 mg). Study outcome(s) The primary outcome is the proportion of patients with an improved modified treatment in cerebral ischemia score 10 min after the end of the study treatment. Secondary outcomes include the shift analysis of the modified Rankin Scale, the infarct expansion ratio, the proportion of excellent outcome (modified Rankin Scale 0–1), the proportion of infarct expansion, and the infarction volume. Mortality and symptomatic intracerebral bleeding will be assessed. Discussion The study will provide evidence whether rescue intraarterial thrombolysis improves brain reperfusion in patients with large vessel occlusion stroke and incomplete reperfusion (modified treatment in cerebral ischemia 2b) at the end of mechanical thrombectomy.

scholarly journals Efficacy and Safety of Recanalization Therapy for Acute Ischemic Stroke With Large Vessel Occlusion

Stroke ◽  
2020 ◽  
Vol 51 (7) ◽  
pp. 2026-2035 ◽  
Author(s):  
Wen Hui ◽  
Chuanjie Wu ◽  
Wenbo Zhao ◽  
Huan Sun ◽  
Jun Hao ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Meta Analysis ◽  
Assessment Tools ◽  
Large Vessel ◽  
Cochrane Central Register ◽  
Large Vessel Occlusion ◽  
Vessel Occlusion ◽  
Intraarterial Thrombolysis

Background and Purpose: The optimal recanalization strategy for acute ischemic stroke with large vessel occlusion continues to be an area of active interest. Network meta-analysis can provide insight when direct comparative evidence is lacking. Methods: A systematic review of the literature using PubMed, Embase, the Cochrane Central Register of Controlled Trials, and SinoMed was performed, and a search was conducted for clinical trials on ClinicalTrials.gov, the World Health Organization International Clinical Trials Registry Platform, and StrokeCenter.org. Four independent reviewers conducted the study selection, data abstraction, and quality assessments. Results: The literature review identified 17 trials including 3236 patients and 8 ongoing clinical trials. Sample sizes ranged from 7 to 656 participants. Intravenous thrombolysis (IVT) was the most common intervention, followed by IVT plus mechanical thrombectomy (MT), IVT plus intraarterial thrombolysis, intraarterial thrombolysis alone, and MT alone. In the pooled network meta-analysis, IVT+MT was associated with a higher rate of independent functioning. In contrast, IVT was ranked as the most ineffective treatment strategy with respect to neurological functions, while direct MT was ranked as the least safe intervention with respect to all-cause mortality. Also, irrespective of assessment tools, endovascular treatment plus IVT led to higher successful recanalization rate than thrombolysis alone. Conclusions: Compared with other recanalization treatments, IVT+MT seems to be the most effective strategy, without increasing detrimental effects, for thrombolysis-eligible patients with large vessel occlusion-acute ischemic stroke. To improve the current evidentiary basis for recanalization treatment, future trials and real-world studies are warranted and should use unified definitions of symptomatic intracranial hemorrhage and recanalization.

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