scholarly journals Cav-1 (Caveolin-1) and Arterial Remodeling in Adult Moyamoya Disease

Stroke ◽  
2018 ◽  
Vol 49 (11) ◽  
pp. 2597-2604 ◽  
Author(s):  
Jong-Won Chung ◽  
Dong Hee Kim ◽  
Mi Jeong Oh ◽  
Yeon Hee Cho ◽  
Eun Hee Kim ◽  
...  
Keyword(s):  
Moyamoya Disease ◽  
Arterial Remodeling ◽  
Caveolin 1 ◽  
Adult Moyamoya Disease

Abstract 110: Caveolin-1 and Arterial Remodeling in Adult Moyamoya Disease

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Jong-Won Chung ◽  
Hyun Ah Choi ◽  
Mi Ji Lee ◽  
Joon Hwa Lee ◽  
Moo-Seok Park ◽  
...  
Keyword(s):  
Moyamoya Disease ◽  
Vesicular Trafficking ◽  
Conventional Angiography ◽  
Caveolin 1 ◽  
High Resolution Mri ◽  
Distal Internal Carotid Artery ◽  
The Mean ◽  
Male Sex ◽  
Adult Moyamoya Disease ◽  
Cerebrovascular Occlusive Disease

Background and purpose: Moyamoya disease (MMD) is a unique cerebrovascular occlusive disease that is characterized by progressive stenosis and negative remodeling of the distal internal carotid artery (ICA). We hypothesized that caveolin-1, a protein that controls the regulation of endothelial vesicular trafficking and signal transduction, is associated with negative remodeling in MMD. Methods: We prospectively recruited 77 consecutive patients with MMD (49 bilateral and 28 unilateral MMD) diagnosed by conventional angiography. Seventeen patients with intracranial atherosclerotic stroke and no RNF213 mutation served as controls. Distal ICA outer diameters were examined with high-resolution MRI. We evaluated whether the degree of negative remodeling in MMD patients was associated with RNF213 polymorphism, caveolin-1 levels, or various clinical and vascular risk factors. Results: The RNF213 variant was observed in 49 (63.6%) patients with MMD. The serum caveolin-1 (ng/mL) level was lower in MMD patients than in controls (0.47±0.29 vs. 0.86±0.68, P =0.034). The mean ICA diameter was 2.48±0.98 mm (range 0.00-4.76) for the 126 affected distal ICAs in MMD patients and 3.84±0.42 mm for asymptomatic ICAs in controls. After adjusting for possible confounders, male sex (coefficient, 0.396; P =0.029), clinical presentation with ischemic stroke (coefficient, -0.733; P <0.001), and caveolin-1 level (coefficient, 1.018; P <0.001) were independently associated with distal ICA diameter in MMD patients. Conclusion: Our findings suggest that caveolin-1 may play a major role in arterial negative remodeling in MMD patients. Future studies exploring caveolin-1 as a therapeutic target in MMD are warranted.

Intralateral and Perilateral Ventricular Arteries on Original Axial Magnetic Resonance Angiography in Adult Moyamoya Disease

2021 ◽  
Vol 84 (2) ◽  
pp. 119-123
Author(s):  
Mami Ishikawa ◽  
Satoshi Terao ◽  
Hiroshi Kagami ◽  
Makoto Inaba ◽  
Heiji Naritaka
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Angiography ◽  
Cerebral Infarction ◽  
Moyamoya Disease ◽  
Disease Onset ◽  
Time Of Flight ◽  
Unruptured Aneurysms ◽  
Tof Mra ◽  
Adult Moyamoya Disease

<b><i>Background:</i></b> Patients with moyamoya disease often develop cerebral infarction and hemorrhage, but the ischemic and hemorrhagic subtypes are difficult to diagnose prior to disease onset. We aimed to differentiate the ischemic and hemorrhagic subtypes of moyamoya disease by analyzing the intralateral and perilateral ventricular arteries on the original axial magnetic resonance angiography (MRA) images. <b><i>Methods:</i></b> We retrospectively analyzed the intralateral and perilateral ventricular arteries on the original axial time-of-flight (TOF)-MRA images of 18 patients with hemorrhagic moyamoya disease, 25 patients with ischemic moyamoya disease, and 22 control patients with unruptured aneurysms. <b><i>Results:</i></b> There were significantly more intralateral and perilateral ventricular arteries on the original axial MRA images in the patients with hemorrhagic moyamoya disease (6.3 ± 2.7) than in those with ischemic moyamoya disease (0.8 ± 0.9) and those with unruptured aneurysms (0.4 ± 0.8). <b><i>Conclusion:</i></b> The intralateral and perilateral ventricular arteries on the original axial TOF-MRA images might suggest the hemorrhagic type of moyamoya disease prior to onset.

Evaluation of neuronal loss in adult moyamoya disease by 123I-iomazenil SPECT

1999 ◽  
Vol 51 (2) ◽  
pp. 158-163 ◽  
Author(s):  
Shinya Sato ◽  
Reizo Shirane ◽  
Shin Maruoka ◽  
Takashi Yoshimoto
Keyword(s):  
Moyamoya Disease ◽  
Neuronal Loss ◽  
Adult Moyamoya Disease

Intracerebral hemorrhage after prophylactic revascularization in a patient with adult moyamoya disease

2007 ◽  
Vol 68 (3) ◽  
pp. 335-337 ◽  
Author(s):  
Yasunari Otawara ◽  
Kuniaki Ogasawara ◽  
Kaoru Seki ◽  
Michihiro Kibe ◽  
Yoshitaka Kubo ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Moyamoya Disease ◽  
Adult Moyamoya Disease

Cerebral hemodynamics and metabolism in adult moyamoya disease: Comparison of angiographic collateral circulation

2004 ◽  
Vol 18 (2) ◽  
pp. 115-121 ◽  
Author(s):  
Rishu Piao ◽  
Naohiko Oku ◽  
Kazuo Kitagawa ◽  
Masao Imaizumi ◽  
Kohji Matsushita ◽  
...  
Keyword(s):  
Moyamoya Disease ◽  
Collateral Circulation ◽  
Cerebral Hemodynamics ◽  
Adult Moyamoya Disease

An atypical case of adult Moyamoya disease with initial onset of brain stem ischemia

1998 ◽  
Vol 157 (1) ◽  
pp. 100-104 ◽  
Author(s):  
Teruyuki Hirano ◽  
Eiichiro Uyama ◽  
Kazuhiro Tashima ◽  
Shuji Mita ◽  
Makoto Uchino
Keyword(s):  
Brain Stem ◽  
Moyamoya Disease ◽  
Atypical Case ◽  
Initial Onset ◽  
Adult Moyamoya Disease ◽  
Brain Stem Ischemia

scholarly journals Edaravone Reduces Hyperperfusion-Related Neurological Deficits in Adult Moyamoya Disease

Stroke ◽  
2016 ◽  
Vol 47 (7) ◽  
pp. 1930-1932 ◽  
Author(s):  
Haruto Uchino ◽  
Naoki Nakayama ◽  
Ken Kazumata ◽  
Satoshi Kuroda ◽  
Kiyohiro Houkin
Keyword(s):  
Moyamoya Disease ◽  
Neurological Deficits ◽  
Adult Moyamoya Disease
Sign in / Sign up

Export Citation Format

Share Document