scholarly journals Quantitative Lesion Water Uptake in Acute Stroke Computed Tomography Is a Predictor of Malignant Infarction

Stroke ◽  
2018 ◽  
Vol 49 (8) ◽  
pp. 1906-1912 ◽  
Author(s):  
Gabriel Broocks ◽  
Fabian Flottmann ◽  
Alexandra Scheibel ◽  
Annette Aigner ◽  
Tobias D. Faizy ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Acute Stroke ◽  
Water Uptake ◽  
Malignant Infarction

Elevated early lesion water uptake in acute stroke predicts poor outcome despite successful recanalization – When “tissue clock” and “time clock” are desynchronized

2019 ◽  
pp. 174749301988452 ◽  
Author(s):  
Jawed Nawabi ◽  
Fabian Flottmann ◽  
Andre Kemmling ◽  
Helge Kniep ◽  
Hannes Leischner ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Acute Stroke ◽  
Water Uptake ◽  
Quantitative Imaging ◽  
Receiver Operating Curve ◽  
Imaging Biomarker ◽  
Poor Clinical Outcome ◽  
Similar Time ◽  
Poor Outcome ◽  
Malignant Infarction

Background Ischemic water uptake in acute stroke is a reliable indicator of lesion age. Nevertheless, inter-individually varying edema progression has been observed and elevated water uptake has recently been described as predictor of malignant infarction. Aims We hypothesized that early-elevated lesion water uptake indicates accelerated “tissue clock” desynchronized with “time clock” and therefore predicts poor clinical outcome despite successful recanalization. Methods Acute middle cerebral artery stroke patients with multimodal admission-CT who received successful thrombectomy (TICI 2b/3) were analyzed. Net water uptake (NWU), a quantitative imaging biomarker of ischemic edema, was determined in admission-CT and tested as predictor of clinical outcome using modified Rankin Scale (mRS) after 90 days. A binary outcome was defined for mRS 0–4 and mRS 5–6. Results Seventy-two patients were included. The mean NWU (SD) in patients with mRS 0–4 was lower compared to patients with mRS 5–6 (5.0% vs. 12.1%; p < 0.001) with similar time from symptom onset to imaging (2.6 h vs. 2.4 h; p = 0.7). Based on receiver operating curve analysis, NWU above 10% identified patients with very poor outcome with high discriminative power (AUC 0.85), followed by Alberta Stroke Program Early CT Score (ASPECTS) (AUC: 0.72) and National Institutes of Health Stroke Scale (NIHSS) (AUC: 0.72). Conclusions Quantitative NWU may serve as an indicator of “tissue clock” and pronounced early brain edema with elevated NWU might suggest a desynchronized “tissue clock” with real “time clock” and therefore predict futile recanalization with poor clinical outcome.

scholarly journals NEURAL NETWORK-BASED SYSTEM OF ACUTE STROKE NON-CONTRAST COMPUTED TOMOGRAPHY DIAGNOSTICS: A COMPARATIVE STUDY

2020 ◽  
Vol 10 (3) ◽  
pp. 36-45
Author(s):  
A. Prokhorikhin ◽  
◽  
V. Baystrukov ◽  
A. Boykov ◽  
D. Malaev ◽  
...  
Keyword(s):  
Neural Network ◽  
Computed Tomography ◽  
Comparative Study ◽  
Acute Stroke

scholarly journals Ischemic Lesion Water Uptake in Acute Stroke: Is Blood Glucose Related to Cause and Effect?

2019 ◽  
Vol 21 (3) ◽  
pp. 347-349 ◽  
Author(s):  
Gabriel Broocks ◽  
Andre Kemmling ◽  
Jens Aberle ◽  
Helge Kniep ◽  
Matthias Bechstein ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Acute Stroke ◽  
Water Uptake ◽  
Ischemic Lesion ◽  
Cause And Effect

Computed Tomography Angiography and Perfusion Imaging of Acute Stroke

2003 ◽  
pp. 165-178
Author(s):  
George Hunter ◽  
Leena M. Hamberg ◽  
Michael H. Lev ◽  
Ramon Gilberto Gonzales
Keyword(s):  
Computed Tomography ◽  
Acute Stroke ◽  
Perfusion Imaging ◽  
Computed Tomography Angiography

scholarly journals Effect of Clinical History on Interpretation of Computed Tomography for Acute Stroke

2019 ◽  
Vol 9 (3) ◽  
pp. 140-143 ◽  
Author(s):  
Peter Hung ◽  
Caitlin Finn ◽  
Monica Chen ◽  
Ashley Knight-Greenfield ◽  
Hediyeh Baradaran ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Acute Stroke ◽  
Clinical History
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