scholarly journals Sustained Neurological Recovery After Stroke in Aged Rats Treated With a Novel Prostacyclin Analog

Stroke ◽  
2017 ◽  
Vol 48 (7) ◽  
pp. 1948-1956 ◽  
Author(s):  
Changjun Yang ◽  
Kelly M. DeMars ◽  
Jon C. Alexander ◽  
Marcelo Febo ◽  
Eduardo Candelario-Jalil
Keyword(s):  
Neurological Recovery ◽  
Aged Rats ◽  
Prostacyclin Analog

scholarly journals Diabetes Mellitus Impairs Cognitive Function in Middle-Aged Rats and Neurological Recovery in Middle-Aged Rats After Stroke

Stroke ◽  
2016 ◽  
Vol 47 (8) ◽  
pp. 2112-2118 ◽  
Author(s):  
Li Zhang ◽  
Michael Chopp ◽  
Yanlu Zhang ◽  
Ye Xiong ◽  
Chao Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Cognitive Function ◽  
Neurological Recovery ◽  
Aged Rats ◽  
Middle Aged

scholarly journals Mesenchymal stromal cell-derived small extracellular vesicles promote neurological recovery and brain remodeling after distal middle cerebral artery occlusion in aged rats

GeroScience ◽  
2021 ◽  
Author(s):  
Danut-Adrian Dumbrava ◽  
Roxana Surugiu ◽  
Verena Börger ◽  
Mihai Ruscu ◽  
Tobias Tertel ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Middle Cerebral Artery Occlusion ◽  
Brain Tissue ◽  
Motor Coordination ◽  
Artery Occlusion ◽  
Neurological Recovery ◽  
Aged Rats ◽  
Brdu Immunohistochemistry ◽  
Cerebral Artery Occlusion ◽  
Brain Macrophage

AbstractSmall extracellular vesicles (sEVs) obtained from mesenchymal stromal cells (MSCs) promote neurological recovery after middle cerebral artery occlusion (MCAO) in young rodents. Ischemic stroke mainly affects aged humans. MSC-sEV effects on stroke recovery in aged rodents had not been assessed. In a head-to-head comparison, we exposed young (4–5 months) and aged (19–20 months) male Sprague–Dawley rats to permanent distal MCAO. At 24 h, 3 and 7 days post-stroke, vehicle or MSC-sEVs (2 × 106 or 2 × 107 MSC equivalents/kg) were intravenously administered. Neurological deficits, ischemic injury, brain inflammatory responses, post-ischemic angiogenesis, and endogenous neurogenesis were evaluated over 28 days. Post-MCAO, aged vehicle-treated rats exhibited more severe motor-coordination deficits evaluated by rotating pole and cylinder tests and larger brain infarcts than young vehicle-treated rats. Although infarct volume was not influenced by MSC-sEVs, sEVs at both doses effectively reduced motor-coordination deficits in young and aged rats. Brain macrophage infiltrates in periinfarct tissue, which were evaluated as marker of a recovery-aversive inflammatory environment, were significantly stronger in aged than young vehicle-treated rats. sEVs reduced brain macrophage infiltrates in aged, but not young rats. The tolerogenic shift in immune balance paved the way for structural brain tissue remodeling. Hence, sEVs at both doses increased periinfarct angiogenesis evaluated by CD31/BrdU immunohistochemistry in young and aged rats, and low-dose sEVs increased neurogenesis in the subventricular zone examined by DCX/BrdU immunohistochemistry. Our study provides robust evidence that MSC-sEVs promote functional neurological recovery and brain tissue remodeling in aged rats post-stroke. This study encourages further proof-of-concept studies in clinic-relevant stroke settings.

The role of asymmetric dimethylarginine in myocardial aging of aged rats and its mechanisms

2010 ◽  
Vol 34 (8) ◽  
pp. S29-S29
Author(s):  
Ru Zhang ◽  
Yong Zhen Gong ◽  
Wen Juan Xu ◽  
Yao Pan ◽  
Yan Xiong
Keyword(s):  
Asymmetric Dimethylarginine ◽  
Aged Rats ◽  
Myocardial Aging

Butea Frondosa, A Rho Kinase 2 and Phosphodiesterase 5 Enzyme Inhibitor, Increases Sexual Function In Young And Aged Rats

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
S Kumar Goswami ◽  
M Naseeruddin Inamdar ◽  
S Dethe ◽  
A Agarwal
Keyword(s):  
Sexual Function ◽  
Enzyme Inhibitor ◽  
Rho Kinase ◽  
Aged Rats ◽  
Phosphodiesterase 5

On the Fibrinolytic System in Aged Rats, and Its Reactivity to Endotoxin and Cytokines

1992 ◽  
Vol 67 (06) ◽  
pp. 697-701 ◽  
Author(s):  
J J Emeis ◽  
A Brouwer ◽  
R J Barelds ◽  
M A Horan ◽  
S K Durham ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Fibrinolytic Activity ◽  
Fibrinolytic System ◽  
Tissue Type ◽  
High Dose ◽  
Base Line ◽  
Aged Rats ◽  
Tissue Type Plasminogen Activator ◽  
Young Rats ◽  
Type Plasminogen Activator

SummaryAged rats are more susceptible to endotoxin-induced effects, including microthrombosis and platelet aggregation, than are young rats. To investigate whether changes in the fibrinolytic system might be involved, we investigated the fibrinolytic activity in plasma euglobulin fractions and tissues (lung and heart) of young (6-months old) and aged (24-months old) rats under baseline conditions and after challenge with endotoxin. Aged rats had lower plasma levels of tissue-type plasminogen activator (t-PA) and of urokinase-type PA (u-PA) activity. PA inhibitor (PAI) activity was higher in the plasma of aged rats, as was t-PA activity in lung and heart.Rats were treated with either a low dose (1 μg/kg) or a high dose (10 mg/kg) of endotoxin. Both treatments induced a transient phase of increased blood fibrinolytic activity, as evidenced by higher levels of tissue-type plasminogen activator (t-PA) activity and decreased levels of PA inhibitor (PAI) activity. Over time, the fibrinolytic activity decreased, probably due to increased levels of PA inhibitor.Both the early increase in t-PA activity, and the subsequent increase in PAI activity, were more pronounced in the aged rats, as compared with the younger rats, after the high dose of endotoxin. The aged rats also responded to an injection of interleukin-1β or tumor necrosis factor-α with a larger increase of PAI activity than did the younger rats.Together the data suggest that, compared to young rats, aged rats have a decreased base-line plasma fibrinolytic activity, while their fibrinolytic system is more responsive to challenge by endotoxin and cytokines.

Accelerated infarct development, cytogenesis and apoptosis following cerebral ischaemia in aged rats

2006 ◽  
Vol 33 (S 1) ◽  
Author(s):  
A. Popa-Wagner ◽  
M. Sascau ◽  
Y. Suofu ◽  
C. Kessler
Keyword(s):  
Cerebral Ischaemia ◽  
Aged Rats

Impact of Various Regimens of Rhythmic Extreme Cold Exposures on Hormone and Lipid Content in Blood Serum of Young and Aged Rats

2019 ◽  
Vol 29 (3) ◽  
pp. 206-220
Author(s):  
Volodymyr Kulik ◽  
◽  
Georgiy Babiichuk ◽  
Vladyslav Babiichuk ◽  
Natalya Malova ◽  
...  
Keyword(s):  
Blood Serum ◽  
Lipid Content ◽  
Aged Rats ◽  
Extreme Cold
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