scholarly journals Shifting Perceptions of Risk and Reward: Use of Anticoagulation in Patients With Acute Brain Ischemia and Atrial Fibrillation

Stroke ◽  
2017 ◽  
Vol 48 (4) ◽  
pp. 1092-1094
Author(s):  
Yvonne Schwammenthal ◽  
Rakefet Tsabari ◽  
David Orion ◽  
Oleg Merzlyak ◽  
Salo Haratz ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Brain Ischemia ◽  
Perceptions Of Risk ◽  
Acute Brain Ischemia

Inflammatory biomarkers in blood of patients with acute brain ischemia

2006 ◽  
Vol 13 (5) ◽  
pp. 505-513 ◽  
Author(s):  
S. Sotgiu ◽  
B. Zanda ◽  
B. Marchetti ◽  
M. L. Fois ◽  
G. Arru ◽  
...  
Keyword(s):  
Brain Ischemia ◽  
Inflammatory Biomarkers ◽  
Acute Brain Ischemia

Abstract 3648: Detection Of Paroxysmal Atrial Fibrillation In Patient With Acute Brain Ischemia Combining Cardiac And Holter Monitoring: Prevalence And Predictors

Stroke ◽  
2012 ◽  
Vol 43 (suppl_1) ◽  
Author(s):  
Patricia Martinez-Sanchez ◽  
Elisa Correas Callero ◽  
Andres Cruz Herranz ◽  
Blanca Fuentes Gimeno ◽  
Angel Martin Montes ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Brain Ischemia ◽  
Paroxysmal Atrial Fibrillation ◽  
Left Atrial ◽  
Duplex Ultrasound ◽  
Unknown Origin ◽  
Holter Monitoring ◽  
Cardiac Monitoring ◽  
Stroke Severity ◽  
Carotid Plaques

INTRODUCTION: The yield of serial electrocardiograms (ECG) plus 72-hour cardiac monitoring and Holter monitoring in detection of paroxysmal atrial fibrillation (PAF) is not well known. METHODS: consecutive patients with stroke or transient ischemic attack (TIA) admitted to a Stroke Unit (SU) during January 2009-June 2010 were studied. Patients underwent serial ECG and cardiac monitoring in the first 72 hours. Furthermore, 24-hours Holter monitoring were performed in patient with brain ischemia of unknown origin or if cardiac embolism was suspected. The presence of atrial fibrillation (AF) and PAF was recorded. RESULTS: 537 patients were included, 59.6% males. Mean age 69.1 (SD 13.5) years. Previous AF was present in 15.8% patients. ECG on admission showed not previously known AF in 22 (4%) patients. Cardiac monitoring and serial ECG in the SU detected PAF in 12 (2.2%) cases more. 24-hours Holter monitoring was completed in 156 patients, in 42 cases PFA was detected, of them 6 had been previously detected by serial ECG/cardiac monitoring. One case of PAF detected by serial ECG was not confirmed by Holter monitoring. In total, 10.8% of patients were diagnosed with new PAF. In multivariate analyses, NIHSS on admission (OR 1.1 for each 1 point increase; 95% CI, 1-1.2), enlarged left atrial (OR 5.8; 95% CI, 2.8-12), absence of carotid plaques by duplex ultrasound (OR 2.1; 95% CI 1-4.4) and hyperlipidemia (OR 2.4; 95% CI 1.119-5) were predictors of PAF. CONCLUSIONS: 24-hours Holter monitoring increased by 6 fold the detection of PAF as compared to ECG plus cardiac monitoring in acute stroke patients. Stroke severity, enlarged left atrial, absence of carotid plaques and hyperlipidemia are associated with PAF.

Clinical neuropsychological pathology profile of Moyamoya disease

2021 ◽  
Vol LII (3) ◽  
pp. 82-87
Author(s):  
Maxim G. Baryshkin ◽  
Alina G. Ahmetshina ◽  
Ksenia V. Pyrkova
Keyword(s):  
Medical History ◽  
Moyamoya Disease ◽  
Brain Ischemia ◽  
Neuropsychological Evaluation ◽  
Acute Brain Ischemia ◽  
The Individual ◽  
Cortical Functions

The goal of this study is to discover and describe the clinical qualities of higher cortical functions in a young Moyamoya patient with acute brain ischemia. We assessed the recovery of higher cortical functions for the period from March 2019 to January 2020. This paper presents the individual patients medical history and the neuropsychological evaluation conducted during the patients rehabilitation in January 2020.

scholarly journals Inflammation and the Emerging Role of the Toll-Like Receptor System in Acute Brain Ischemia

Stroke ◽  
2008 ◽  
Vol 40 (3, Supplement 1) ◽  
pp. S34-S37 ◽  
Author(s):  
B. J. Marsh ◽  
S. L. Stevens ◽  
B. Hunter ◽  
M. P. Stenzel-Poore
Keyword(s):  
Brain Ischemia ◽  
Toll Like Receptor ◽  
Receptor System ◽  
Acute Brain Ischemia

236: The Prognostic Value of Serum Troponin T In Acute Brain Ischemia

2010 ◽  
Vol 56 (3) ◽  
pp. S78
Author(s):  
L.G. Stead ◽  
A. Jain ◽  
M. Bellolio ◽  
A. Bhagra ◽  
R.M. Gilmore ◽  
...  
Keyword(s):  
Brain Ischemia ◽  
Prognostic Value ◽  
Troponin T ◽  
Acute Brain Ischemia

S100 as a Marker of Acute Brain Ischemia: A Systematic Review

2007 ◽  
Vol 8 (2) ◽  
pp. 301-307 ◽  
Author(s):  
David L. Nash ◽  
M. Fernanda Bellolio ◽  
Latha G. Stead
Keyword(s):  
Systematic Review ◽  
Brain Ischemia ◽  
Acute Brain Ischemia

scholarly journals Multitracer Studies in Acute Brain Ischemia and Reply

1987 ◽  
Vol 7 (1) ◽  
pp. 132-132
Author(s):  
Jesus A. Bianco ◽  
Steven Jones
Keyword(s):  
Brain Ischemia ◽  
Acute Brain Ischemia

Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia

2015 ◽  
Vol 7 (299) ◽  
pp. 299ra121-299ra121 ◽  
Author(s):  
Gemma Llovera ◽  
Kerstin Hofmann ◽  
Stefan Roth ◽  
Angelica Salas-Pérdomo ◽  
Maura Ferrer-Ferrer ◽  
...  
Keyword(s):  
Brain Ischemia ◽  
Multicenter Trial ◽  
Randomized Controlled ◽  
Acute Brain Ischemia

Abstract 174: Roles of Pericyte NADPH Oxidase 4 in Acute Brain Ischemia

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Ataru Nishimura ◽  
Tetsuro Ago ◽  
Masaki Tachibana ◽  
Noriko Makihara ◽  
Ryu Matsuo ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Brain Ischemia ◽  
Infarct Volume ◽  
Neurovascular Unit ◽  
Double Labeling ◽  
Nadph Oxidase 4 ◽  
Brain Pericytes ◽  
Acute Brain Ischemia ◽  
Nox Family ◽  
The Brain

Pericytes exist abundantly in the brain and compose the neurovascular unit. It has been elucidated that pericytes play a key role in the formation and maintenance of the blood-brain barrier (BBB), thus being considered to play significant roles in brain ischemia. The NADPH oxidase (Nox) family proteins are a major source of reactive oxygen species (ROS). We have reported previously that Nox4 is abundantly expressed in pericytes among the Nox family. Our goal was to elucidate the roles of Nox4 in brain pericytes during acute brain ischemia. We confirmed by quantitative PCR that Nox4 was abundantly expressed in human cultured brain microvascular pericytes (HBMPC) and was significantly upregulated by hypoxia. We produced a mouse middle cerebral artery occlusion (MCAO) stroke model and examined the expression of Nox4 in the brain. Immunofluorescent double labeling demonstrated that Nox4 expression was upregulated in microvessels particularly in peri-infarct areas and was co-stained with PDGFRβ, a pericyte marker. In order to elucidate the role of Nox4 in brain pericyte during brain ischemia, we generated mice with human Nox4 overexpression using a promoter of SM22α, a pericyte/smooth muscle cell marker (Tg-Nox4). We confirmed that SM22α was expressed in mouse brain pericytes by co-immunostaining with PDGFRβ. We isolated microvessels from Tg-Nox4 brain and confirmed that human Nox4 mRNA was highly expressed. In MCAO model, the infarct volume was significantly larger in Tg-Nox4 than in littermate controls. Confocal microscopy demonstrated that IgG leakage in peri-infarct areas was significantly increased in Tg-Nox4, suggesting that Nox4 overexpression in pericytes enhanced BBB breakdown during acute brain ischemia. To elucidate the mechanisms, we induced adenovirus-mediated overexpression of Nox4 in HBMPC. We demonstrated that Nox4 overexpression increased NFκB phosphorylation and MMP9 expression in the cells.In conclusion, Nox4 may be a major source of ROS in brain pericytes and is upregulated directly by hypoxia in peri-infarct areas during acute brain ischemia. Pericyte Nox4 may enhance BBB breakdown through the activation of NFκB-MMP9 signaling during acute brain ischemia.

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