scholarly journals Valproate Reduces Delayed Brain Injury in a Rat Model of Subarachnoid Hemorrhage

Stroke ◽  
2017 ◽  
Vol 48 (2) ◽  
pp. 452-458 ◽  
Author(s):  
Arend M. Hamming ◽  
Annette van der Toorn ◽  
Umesh S. Rudrapatna ◽  
Lisha Ma ◽  
Hine J.A. van Os ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Rat Model ◽  
Delayed Brain Injury

Treatment of early brain injury after subarachnoid hemorrhage in the rat model by inhibiting p53-induced ferroptosis

2021 ◽  
pp. 136134
Author(s):  
Hong Kuang ◽  
Tianhong Wang ◽  
Lei Liu ◽  
Chunhai Tang ◽  
Tao Li ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Rat Model ◽  
Early Brain Injury

Tetramethylpyrazine Protects Against Early Brain Injury and Inhibits the PERK/Akt Pathway in a Rat Model of Subarachnoid Hemorrhage

2018 ◽  
Vol 43 (8) ◽  
pp. 1650-1659 ◽  
Author(s):  
Zhengkai Shao ◽  
Pei Wu ◽  
Xuefeng Wang ◽  
Meishan Jin ◽  
Shuang Liu ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Rat Model ◽  
Early Brain Injury ◽  
Akt Pathway

PARP inhibition attenuates early brain injury through NF-κB/MMP-9 pathway in a rat model of subarachnoid hemorrhage

2016 ◽  
Vol 1644 ◽  
pp. 32-38 ◽  
Author(s):  
Ting Chen ◽  
Wei Wang ◽  
Jian-Ru Li ◽  
Hang-Zhe Xu ◽  
Yu-Cong Peng ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Rat Model ◽  
Early Brain Injury ◽  
Parp Inhibition

Microglia inflict delayed brain injury after subarachnoid hemorrhage

2015 ◽  
Vol 130 (2) ◽  
pp. 215-231 ◽  
Author(s):  
Ulf C. Schneider ◽  
Anja-Maria Davids ◽  
Susan Brandenburg ◽  
Annett Müller ◽  
Anna Elke ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Delayed Brain Injury

scholarly journals Melatonin affects hypoxia-inducible factor 1α and ameliorates delayed brain injury following subarachnoid hemorrhage via H19/miR-675/HIF1A/TLR4

2020 ◽  
Author(s):  
Da-yong Xia ◽  
Xiao-chun Jiang ◽  
Zhen-bao Li ◽  
Yi Dai ◽  
Zi-huan Zhang ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Hypoxia Inducible Factor ◽  
Luciferase Assay ◽  
Tlr4 Expression ◽  
Hypoxia Inducible Factor 1Α ◽  
Protein Levels ◽  
Transcription Efficiency ◽  
Delayed Brain Injury ◽  
Neurobehavioral Deficits

Abstract Background: This study was aimed to investigate the molecular mechanism of how melatonin interferes with hypoxia-inducible factor 1α (HIF1A) and TLR4 expression, which is implicated in the management of delayed brain injury (DBI) after subarachnoid hemorrhage (SAH). Method: Luciferase assay, real-time PCR, Western-blot analysis and immunohistochemistry (IHC) assays were utilized to explore the interaction among H19, miR-675, HIF1A and TLR4, and to evaluate the effect of MT on the expression of above transcripts in different groups. Results: MT enhanced H19 expression by promoting the transcription efficiency of H19 promoter, and HIF1A was identified as a target of miR-675. HIF1A enhanced TLR4 expression via promoting the transcription efficiency of TLR4 promoter. Furthermore, administration of MT up-regulated miR-675 but suppressed the expressions of HIF1A and TLR4. Treatment with MT alleviated neurobehavioral deficits and apoptosis induced by SAH. According to the result of IHC, HIF1A and TLR4 protein levels in the SAH group were much higher than those in the SAH+MT group. Therefore, the administration of MT increased the levels of H19 and miR-675 which have been inhibited by SAH. In a similar way, treatment with MT decreased the levels of HIF1A and TLR4 which have been enhanced by SAH. Conclusion: MT could down-regulate the expression of HIF1A and TLR4 via the H19/miR-675/HIF1A/TLR4 signaling pathway, while TLR4 is crucial to the release of pro-inflammatory cytokines. Therefore, the treatment with MT could ameliorate post-SAH DBI.

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