scholarly journals Inhibition of Thrombin-Activatable Fibrinolysis Inhibitor and Plasminogen Activator Inhibitor-1 Reduces Ischemic Brain Damage in Mice

Stroke ◽  
2016 ◽  
Vol 47 (9) ◽  
pp. 2419-2422 ◽  
Author(s):  
Frederik Denorme ◽  
Tine Wyseure ◽  
Miet Peeters ◽  
Nele Vandeputte ◽  
Ann Gils ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Brain Damage ◽  
Plasminogen Activator Inhibitor ◽  
Plasminogen Activator Inhibitor 1 ◽  
Thrombin Activatable Fibrinolysis Inhibitor ◽  
Ischemic Brain Damage ◽  
Ischemic Brain ◽  
Fibrinolysis Inhibitor ◽  
Activator Inhibitor ◽  
Inhibition Of Thrombin

scholarly journals Increased plasminogen activator inhibitor-1, decreased tissue factor pathway inhibitor, and unchanged thrombin-activatable fibrinolysis inhibitor levels in patients with primary hyperparathyroidism

2009 ◽  
Vol 160 (5) ◽  
pp. 863-868 ◽  
Author(s):  
Cihangir Erem ◽  
Mustafa Kocak ◽  
İrfan Nuhoglu ◽  
Mustafa Yilmaz ◽  
Ozge Ucuncu
Keyword(s):  
Plasminogen Activator ◽  
Tissue Factor Pathway Inhibitor ◽  
Plasminogen Activator Inhibitor ◽  
Plasminogen Activator Inhibitor 1 ◽  
Thrombin Activatable Fibrinolysis Inhibitor ◽  
Tissue Plasminogen ◽  
Fibrinolysis Inhibitor ◽  
Tissue Factor Pathway ◽  
Activator Inhibitor ◽  
Pai 1

Background and objectivesPrimary hyperparathyroidism (PHPT) is associated with increased cardiovascular mortality and morbidity. Little is known about hemostatic features of patients with PHPT. To our knowledge, plasma tissue factor pathway inhibitor (TFPI) and thrombin-activatable fibrinolysis inhibitor (TAFI) levels in these patints have not been investigated. Therefore, the main purpose of this study was to evaluate the markers of endogenous coagulation/fibrinolysis, including TFPI and TAFI, and to investigate the relationships between serum calcium and PTH and these hemostatic parameters in patients with PHPT.Design and methodsTwenty-four patients with PHPT and 20 age-, sex-, and-weight-matched healthy controls were included in the study. Tissue plasminogen activator (t-PA), tissue plasminogen activator inhibitor-1 (PAI-1), TFPI, and TAFI were measured. The relationships between serum calcium, phosphorus, and PTH and these hemostatic parameters were examinated.ResultsCompared with the control subjects, t-PA, PAI-1, and PAI-1/t-PA ratios were significantly increased in patients with PHPT (P<0.0001), whereas TFPI levels were significantly decreased (P<0.0001). Plasma TAFI Ag levels did not significantly change in patients with PHPT compared with the controls. In patients with PHPT, serum phosphorus was negatively correlated with plasma PAI-1 Ag levels and PAI-1/t-PA ratio (r: −0.453,P<0.05;r: −0.580,P<0.01 respectively). There was a positive correlation between Cl/P ratio and plasma PAI-1 levels and PAI-1/t-PA ratio (r: 0.434,P<0.05;r: 0.528,P<0.05 respectively). iPTH was positively correlated with plasma PAI-1/t-PA ratio (r: 0.429,P<0.05).Interpretation and conclusionsIn conclusion, we found some important differences in the hemostatic parameters between the patients with PHPT and healthy controls. Increased PAI-1, PAI-1/t-PA ratios and decreased TFPI levels in these patients represent a potential hypercoagulable and hypofibrinolytic state, which might augment the risk for atherosclerotic and atherothrombotic complications. This condition may contribute to the excess mortality due to cardiovascular disease seen in patients with PHPT.

scholarly journals Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) Antigen and Activity Assay in Patients With Primary Hypothyroidism

2009 ◽  
Vol 16 (5) ◽  
pp. 568-573 ◽  
Author(s):  
Nilay Ermantas ◽  
Sibel Guldiken ◽  
Muzaffer Demir ◽  
Armagan Tugrul
Keyword(s):  
Plasminogen Activator ◽  
Plasminogen Activator Inhibitor ◽  
Plasminogen Activator Inhibitor 1 ◽  
Thrombin Activatable Fibrinolysis Inhibitor ◽  
Fibrinolysis Inhibitor ◽  
Euthyroid Status ◽  
Hypothyroid Patients ◽  
Activator Inhibitor ◽  
Pai 1 ◽  
Tsh Levels

Hypothyroidism causes a tendency for cardiovascular diseases. It was recently shown that thrombin-activatable fibrinolysis inhibitor (TAFI) attenuates fibrinolysis and also fibrin-plasminogen interaction by the removal of lysine and arginine residues from fibrin monomers. The aim of this study was to determine the effects of overt hypothyroidism on the levels of TAFI antigen (TAFI Ag) and TAFI activity (TAFIa). Thirty-one overt primary hypothyroid patients and age- and gender-matched 25 healthy controls were enrolled in the study. Patients were treated with L-thyroxine after the collection of blood samples. Thyroid functions were reevaluated following the achievement of euthyroid status. Thrombin-activatable fibrinolysis inhibitor Ag, tissue plasminogen activator (t-PA), and plasminogen activator inhibitor 1 (PAI-1) levels were measured with the enzyme-linked immunosorbent assay (ELISA). Thrombin-activatable fibrinolysis inhibitor activity was assessed with the chromogenic assay. Thrombin-activatable fibrinolysis inhibitor Ag (1.63% ± 0.42% vs 1.32% ± 0.36%, P < .01) and TAFIa (14.2 ± 4.12 vs 11.6 ± 3.49 μg/mL, P < .05) levels were elevated in hypothyroid patient compared to controls. Plasminogen activator inhibitor 1 and t-PA levels were not significantly different between both groups. In hypothyroid patients, TAFI Ag levels were correlated with free T4 (r = -.373, P < .05) and thyroid-stimulating hormone (TSH) levels (r = .748, P < .001). Regression analysis showed that TSH levels were predictors of TAFI Ag levels (P < .001, β =.671, 95% confidence interval [CI]: 0.008-0.017). Following L-thyroxine treatment, TAFI Ag (1.63% ± 0.42%, 1.34% ± 0.33%, P < .05) and TAFIa (14.2 ± 4.12 μg/mL, 12.0 ± 2.77 μg/mL, P < .05) levels were significantly decreased, but t-PA and PAI-1 levels remained unchanged. This results point out that the fibrinolytic activity was decreased in hypothyroid patients, and therefore the achievement of euthyroid status is important in ameliorating the increased risk of cardiovascular disease.

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