scholarly journals Response to Letter Regarding Article, “Ischemic Stroke Risk in Patients With Atrial Fibrillation and CHA 2 DS 2 -VASc Score of 1: Systematic Review and Meta-Analysis”

Stroke ◽  
2016 ◽  
Vol 47 (7) ◽  
Author(s):  
Raed A. Joundi ◽  
Lauren E. Cipriano ◽  
Luciano A. Sposato ◽  
Gustavo Saposnik
Keyword(s):  
Atrial Fibrillation ◽  
Systematic Review ◽  
Ischemic Stroke ◽  
Stroke Risk ◽  
Meta Analysis ◽  
Ischemic Stroke Risk

scholarly journals Paraoxonase 1 polymorphisms and ischemic stroke risk: A systematic review and meta-analysis

2010 ◽  
Vol 12 (10) ◽  
pp. 606-615 ◽  
Author(s):  
Issa J Dahabreh ◽  
Georgios D Kitsios ◽  
David M Kent ◽  
Thomas A Trikalinos
Keyword(s):  
Systematic Review ◽  
Ischemic Stroke ◽  
Stroke Risk ◽  
Meta Analysis ◽  
Paraoxonase 1 ◽  
Ischemic Stroke Risk

Refinement of Ischemic Stroke Risk in Patients with Atrial Fibrillation and CHA2DS2-VASc Score of 1

2014 ◽  
Vol 37 (11) ◽  
pp. 1442-1447 ◽  
Author(s):  
DUO HUANG ◽  
LUO ANGUO ◽  
WEN-SHENG YUE ◽  
LIXUE YIN ◽  
HUNG-FAT TSE ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Stroke Risk ◽  
Ischemic Stroke Risk

Correlations of ANP Genetic Polymorphisms and Serum Levels with Ischemic Stroke Risk: A Meta-Analysis

2014 ◽  
Vol 18 (5) ◽  
pp. 349-356 ◽  
Author(s):  
De-Guang Xing ◽  
Dong-Yong Zhang ◽  
Zhan-Fu Wang ◽  
Da-Ling Ding ◽  
Jun Wang ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Genetic Polymorphisms ◽  
Stroke Risk ◽  
Meta Analysis ◽  
Serum Levels ◽  
Ischemic Stroke Risk

Risk of ischemic stroke in asymptomatic atrial fibrillation incidentally-detected in primary care compared with other clinical presentations

2021 ◽  
Author(s):  
Christopher Wallenhorst ◽  
Carlos Martinez ◽  
Ben FREEDMAN
Keyword(s):  
Atrial Fibrillation ◽  
Primary Care ◽  
Ischemic Stroke ◽  
Stroke Risk ◽  
Practice Research ◽  
Mortality Data ◽  
Clinical Practice Research Datalink ◽  
Primary Hospital ◽  
Ischemic Stroke Risk ◽  
The Uk

Background: It is uncertain whether stroke risk of asymptomatic ambulatory atrial fibrillation (AA-AF) incidentally-detected in primary care is comparable with other clinical AF presentations in primary care or hospital. Methods: The stoke risk of 22,035 patients with incident non-valvular AF from the UK primary care Clinical Practice Research Datalink with linkage to hospitalization and mortality data, was compared to 23,605 controls without AF (age and sex-matched 5:1 to 5,409 AA-AF patients). Incident AF included 5,913 with symptomatic ambulatory AF (SA-AF); 4,989 with Primary and 5,724 with non-Primary Hospital AF discharge diagnosis (PH-AF and Non-PH-AF); and 5,409 with AA-AF. Ischemic stroke adjusted subhazard ratios (aSHR) within 3 years of AA-AF were compared with SA-AF, PH-AF, Non-PH-AF and controls, accounting for mortality as competing risk and adjusted for ischemic stroke risk factors. Results: There were 1026 ischemic strokes in 49,544 person-years in patients with incident AF (crude incidence rate 2.1 ischemic strokes/100 person-years). Ischemic stroke aSHR over 3 years showed no differences between AA-AF, and SA-AF, PH-AF and nonPH-AF groups (aSHR 0.87-1.01 vs AA-AF). All AF groups showed a significantly higher aSHR compared to controls. (subhazard rate ratio 0.40 [0.34 - 0.47]. Conclusion: Ischemic stroke risk in patients with AA-AF incidentally-detected in primary care is far from benign, and not less than incident AF presenting clinically in general practice or hospital. This provides justification for identification of previously undetected AF, e.g. by opportunistic screening, and subsequent stroke prevention with thromboprophylaxis, to reduce the approximately 10% of ischemic strokes related to unrecognized AF.

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