scholarly journals Characterization of White Matter Injury in a Rat Model of Chronic Cerebral Hypoperfusion

Stroke ◽  
2016 ◽  
Vol 47 (2) ◽  
pp. 542-547 ◽  
Author(s):  
Bo-Ryoung Choi ◽  
Dong-Hee Kim ◽  
Dong Bin Back ◽  
Chung Hwan Kang ◽  
Won-Jin Moon ◽  
...  
Keyword(s):  
White Matter ◽  
Rat Model ◽  
Chronic Cerebral Hypoperfusion ◽  
White Matter Injury ◽  
Cerebral Hypoperfusion

The Effects of Astrocyte and Oligodendrocyte Lineage Cell Interaction on White Matter Injury under Chronic Cerebral Hypoperfusion

Neuroscience ◽  
2019 ◽  
Vol 406 ◽  
pp. 167-175 ◽  
Author(s):  
Shunsuke Magami ◽  
Nobukazu Miyamoto ◽  
Yuji Ueno ◽  
Kenichiro Hira ◽  
Ryota Tanaka ◽  
...  
Keyword(s):  
White Matter ◽  
Cell Interaction ◽  
Chronic Cerebral Hypoperfusion ◽  
White Matter Injury ◽  
Cerebral Hypoperfusion

scholarly journals The protective effect of Thai Herbal Sahatsatara formula against white matter injury after chronic cerebral hypoperfusion in middle-aged rats

ScienceAsia ◽  
2020 ◽  
Vol 46 (6) ◽  
pp. 713
Author(s):  
Saruda Kuraeiad ◽  
Anchalee Vattarakorn ◽  
Onusa Thamsermsang ◽  
Pravit Akarasereenont ◽  
Sompol Tapechum ◽  
...  
Keyword(s):  
White Matter ◽  
Protective Effect ◽  
Chronic Cerebral Hypoperfusion ◽  
White Matter Injury ◽  
Cerebral Hypoperfusion ◽  
Aged Rats ◽  
Middle Aged

scholarly journals Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion

2018 ◽  
Vol 138 ◽  
pp. 360-370 ◽  
Author(s):  
Amanda Santiago ◽  
Lígia Mendes Soares ◽  
Melissa Schepers ◽  
Humberto Milani ◽  
Tim Vanmierlo ◽  
...  
Keyword(s):  
White Matter ◽  
Chronic Cerebral Hypoperfusion ◽  
White Matter Injury ◽  
Cerebral Hypoperfusion ◽  
Aged Rats ◽  
Memory Recovery

scholarly journals Characterization of Tauopathy in a Rat Model of Post-Stroke Dementia Combining Acute Infarct and Chronic Cerebral Hypoperfusion

2020 ◽  
Vol 21 (18) ◽  
pp. 6929
Author(s):  
Dong Bin Back ◽  
Bo-Ryoung Choi ◽  
Jung-Soo Han ◽  
Kyoung Ja Kwon ◽  
Dong-Hee Choi ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Cognitive Impairment ◽  
Acute Ischemic Stroke ◽  
Rat Model ◽  
Artery Occlusion ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Tau Hyperphosphorylation ◽  
Post Stroke

Post-stroke dementia (PSD) is a major neurodegenerative consequence of stroke. Tauopathy has been reported in diverse neurodegenerative diseases. We investigated the cognitive impairment and pathomechanism associated with tauopathy in a rat model of PSD by modeling acute ischemic stroke and underlying chronic cerebral hypoperfusion (CCH). We performed middle cerebral artery occlusion (MCAO) surgery in rats to mimic acute ischemic stroke, followed by bilateral common carotid artery occlusion (BCCAo) surgery to mimic CCH. We performed behavioral tests and focused on the characterization of tauopathy through histology. Parenchymal infiltration of cerebrospinal fluid (CSF) tracers after intracisternal injection was examined to evaluate glymphatic function. In an animal model of PSD, cognitive impairment was aggravated when BCCAo was combined with MCAO. Tauopathy, manifested by tau hyperphosphorylation, was prominent in the peri-infarct area when CCH was combined. Synergistic accentuation of tauopathy was evident in the white matter. Microtubules in the neuronal axon and myelin sheath showed partial colocalization with the hyperphosphorylated tau, whereas oligodendrocytes showed near-complete colocalization. Parenchymal infiltration of CSF tracers was attenuated in the PSD model. Our experimental results suggest a hypothesis that CCH may aggravate cognitive impairment and tau hyperphosphorylation in a rat model of PSD by interfering with tau clearance through the glymphatic system. Therapeutic strategies to improve the clearance of brain metabolic wastes, including tau, may be a promising approach to prevent PSD after stroke.

scholarly journals Characterization of White Matter Injury in a Hypoxic-Ischemic Neonatal Rat Model by Diffusion Tensor MRI

Stroke ◽  
2008 ◽  
Vol 39 (8) ◽  
pp. 2348-2353 ◽  
Author(s):  
Silun Wang ◽  
Ed X. Wu ◽  
Chung Nga Tam ◽  
Ho-Fai Lau ◽  
Pik-To Cheung ◽  
...  
Keyword(s):  
White Matter ◽  
Rat Model ◽  
Diffusion Tensor ◽  
White Matter Injury ◽  
Neonatal Rat ◽  
Diffusion Tensor Mri ◽  
Neonatal Rat Model

Minocycline attenuates white matter damage in a rat model of chronic cerebral hypoperfusion

2006 ◽  
Vol 83 (2) ◽  
pp. 285-291 ◽  
Author(s):  
Kyung-Ok Cho ◽  
Hyen O. La ◽  
Young-Jin Cho ◽  
Ki-Wug Sung ◽  
Seong Y. Kim
Keyword(s):  
White Matter ◽  
Rat Model ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
White Matter Damage

scholarly journals Depletion of microglia ameliorates white matter injury and cognitive impairment in a mouse chronic cerebral hypoperfusion model

2019 ◽  
Vol 514 (4) ◽  
pp. 1040-1044 ◽  
Author(s):  
Masashi Kakae ◽  
Shota Tobori ◽  
Misa Morishima ◽  
Kazuki Nagayasu ◽  
Hisashi Shirakawa ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Chronic Cerebral Hypoperfusion ◽  
White Matter Injury ◽  
Cerebral Hypoperfusion
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