scholarly journals Effect of Collateral Blood Flow on Patients Undergoing Endovascular Therapy for Acute Ischemic Stroke

Stroke ◽  
2014 ◽  
Vol 45 (4) ◽  
pp. 1035-1039 ◽  
Author(s):  
Michael P. Marks ◽  
Maarten G. Lansberg ◽  
Michael Mlynash ◽  
Jean-Marc Olivot ◽  
Matus Straka ◽  
...  
Keyword(s):  
Blood Flow ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Endovascular Therapy ◽  
Collateral Blood Flow

Abstract TP127: Impact of Smoking on Collateral Blood Flow in Patients With Acute Ischemic Stroke With Large Cerebral Artery Embolic Occlusion

Stroke ◽  
2019 ◽  
Vol 50 (Suppl_1) ◽  
Author(s):  
George K Vilanilam ◽  
Mohammed K Badi ◽  
Emily G McCoy ◽  
Caitlin E D'Souza ◽  
Tara L Becker ◽  
...  
Keyword(s):  
Blood Flow ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Cerebral Artery ◽  
Collateral Blood Flow

scholarly journals Preserved Collateral Blood Flow in the Endovascular M2CAO Model Allows for Clinically Relevant Profiling of Injury Progression in Acute Ischemic Stroke

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0169541 ◽  
Author(s):  
Philip Little ◽  
Ola Kvist ◽  
Rikard Grankvist ◽  
Stefan Jonsson ◽  
Peter Damberg ◽  
...  
Keyword(s):  
Blood Flow ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Collateral Blood Flow ◽  
Injury Progression

Abstract P321: The Cerebral Collateral Cascade: Rethinking the Assessment of Vascular Pathways in Acute Ischemic Stroke Patients

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Tobias D Faizy ◽  
Michael Mlynash ◽  
Reza Kabiri ◽  
Soren Christensen ◽  
Gabriella Kuraitis ◽  
...  
Keyword(s):  
Blood Flow ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Ct Perfusion ◽  
Infarct Volume ◽  
Strong Predictor ◽  
Secondary Outcome ◽  
Collateral Blood Flow ◽  
Vessel Occlusion ◽  
Cortical Vein

Background and Purpose: Robust collateral blood flow in patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO) has been correlated with favorable outcomes. Collaterals are commonly assessed by the number of arteries present on non-invasive CT angiography (CTA) overlying ischemic brain, but blood transit from these arteries through the brain tissue and the venous drainage is not assessed by this technique. We hypothesized that a comprehensive imaging analysis of the cerebral collateral cascade (CCC) would predict clinical and radiological outcomes in patients with AIS-LVO patients. Materials and Methods: Multicenter retrospective cohort study of AIS-LVO patients undergoing thrombectomy triage. CCC was determined on pre-treatment imaging by scoring for pial arterial collaterals, tissue-level collaterals (TLC), and venous outflow. Pial arterial collaterals were determined by CTA (Tan scale), TLC were assessed on CT perfusion data using the Hypoperfusion Intensity Ratio, and venous egress was assessed on CTA using the cortical vein opacification score system. 3 groups were defined: CCC+ (good pial collaterals, TLC, and venous perfusion), CCC- (poor pial collaterals, TLC, and venous perfusion) and CCCmixed (reminder of patients). Primary outcome was a good functional outcome (modified Rankin Scale [mRS] 0-2 at 90 days). Secondary outcome was final infarct volume. Results: 647 patients met inclusion criteria: 176 CCC+, 345 CCCmixed and 126 CCC-. Multivariate ordinal logistic regression showed that CCC+ predicted good functional outcomes (mRS 0-2: OR=20.8 [95% CI 9.3-46.8]; p<0.001) compared to CCC- and CCCmixed. CCCmixed (β: 27.1, SE: 7.7; p<0.001) and CCC- (β: 86.6, SE: 9.9; p<0.001) profiles were associated with higher final infarct volumes after treatment compared to CCC+. Conclusion: Comprehensive assessment of the collateral blood flow cascade in AIS-LVO patients is a strong predictor of clinical and radiological outcomes in AIS-LVO patients.

scholarly journals Current status of endovascular therapy for acute ischemic stroke

2013 ◽  
Vol 53 (11) ◽  
pp. 1166-1168
Author(s):  
Hiroshi Yamagami ◽  
Nobuyuki Sakai
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Endovascular Therapy ◽  
Current Status

Endovascular Therapy for Acute Ischemic Stroke

2015 ◽  
Vol 72 (10) ◽  
pp. 1101 ◽  
Author(s):  
Mark J. Alberts ◽  
Ty Shang ◽  
Alejandro Magadan
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Endovascular Therapy

Abstract 2825: History of Cancer Predicts Mortality After Acute Endovascular Treatment for Ischemic Stroke

Stroke ◽  
2012 ◽  
Vol 43 (suppl_1) ◽  
Author(s):  
Karl Meisel ◽  
Mahesh Jayaraman ◽  
Jonathan Grossberg ◽  
Anthony Kim
Keyword(s):  
Ischemic Stroke ◽  
Endovascular Treatment ◽  
Acute Ischemic Stroke ◽  
Endovascular Therapy ◽  
Hospice Care ◽  
Exploratory Analysis ◽  
Endovascular Intervention ◽  
Consecutive Series ◽  
History Of ◽  
History Of Cancer

Introduction: Endovascular treatment is an emerging therapy for acute ischemic stroke. There is no clear consensus about how best to select patients that may benefit from intervention. We conducted an exploratory analysis of clinical risk factors to predict mortality after endovascular intervention in order to better understand how to improve outcomes for patients with acute ischemic stroke. Methods: We identified consecutive series of patients treated with endovascular therapy for acute ischemic stroke at two academic hospitals between 2005 to 2010. Key clinical data elements and clinical outcomes at the time of discharge were abstracted from medical records. We evaluated univariate and multivariable associations using logistic regression and compared mean NIH Stroke Scale between those with and without a history of cancer using the t-test. Results: We identified 88 patients who received endovascular intervention with intra-arterial tissue plasminogen activator (t-PA) and/or mechanical thrombectomy. The mean age of the cohort was 68.2 (SD 16.6) and 44 (55%) were female. A total of 23 (26.1%) patients died during the index hospitalization or were discharged to hospice care. A history of cancer was documented in 20 (22.7%) patients. A history of cancer was associated with a 3.2-fold (95% CI 1.1-9.1) higher odds of mortality. This association persisted after adjusting for age greater than 80 years and hypertension (OR of 4.0, 95% CI 1.3-12). The average NIH Stroke Scale was 15.6 in those with cancer compared to 14.6 without (p=0.53). A history of cancer was not associated with parenchymal hemorrhagic transformation (OR 1.2, 95% CI 0.3-4.9), IV tPA (OR 0.5, 95% CI 0.1-2.3), a TIMI score of 2b or 3 (OR 0.5, 95% CI 0.2-1.3), or an internal carotid artery occlusion (OR 1.7, 95% CI 0.5-5.1). Conclusions: In an exploratory analysis of consecutive patients with acute ischemic stroke treated with endovascular therapy, a history of cancer was strongly associated with significantly increased odds of mortality. One possible explanation could be that patients with cancer may have earlier withdrawal of care but the reasons for this observed association are unclear. Further investigation is necessary to verify and explain the reasons for this observation in order to improve outcomes for acute ischemic stroke patients.

Abstract T P10: Therapeutic Time Window for Endovascular Therapy of Acute Ischemic Stroke Depends on THRIVE Score: A Retrospective Single-center Study

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Kenichi Todo ◽  
Nobuyuki Sakai ◽  
Tomoyuki Kono ◽  
Taku Hoshi ◽  
Hirotoshi Imamura ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Endovascular Therapy ◽  
Time Window ◽  
Medical Center ◽  
Multivariate Logistic Regression Analysis ◽  
Symptom Duration ◽  
Vascular Events ◽  
Good Outcome ◽  
Therapeutic Time Window

Background and purpose: The outcome after endovascular therapy in acute ischemic stroke is associated with onset-to-reperfusion time (ORT). The Totaled Health Risks in Vascular Events (THRIVE) score is also an important pre-thrapeutic predictor of outcome. We hypothesized that the therapeutic time window is narrower in patients with the higher THRIVE score. Methods: We retrospectively studied consecutive 109 ischemic stroke patients with successful reperfusion after endovascular therapy between October 2005 and March 2014 at a single institute (Kobe City Medical Center General Hospital). Inclusion criteria was as follows: National Institutes of Health Stroke Scale (NIHSS) score ≥8, stroke symptom duration ≤8 h, premorbid modified Rankin Scale (mRS) score ≤2, and thrombolysis myocardial infarction score 2-3. We analyzed the relationships of ORT, THRIVE score, and THRIVE+ORT score with good outcome (mRS ≤2 at 3 months). The THRIVE+ORT score was defined as the sum of the THRIVE score and ORT (h). Results: Median ORT was 5.5 h (IQR; 4.4-7.1 h), median THRIVE score was 5 (IQR; 4-6), and median THRIVE+ORT score was 10.8 (IQR; 9.2-12.5). Good outcome rates for patients with ORT ≤4 h, >4 and ≤6 h, >6 and ≤8 h, and >8h were 50.0%, 45.8%, 37.0%, and 21.4%, respectively (p=0.3), those with THRIVE score ≤3, >3 and ≤5, >5 and ≤7, and >7 were 57.1%, 51.4%, 28.3%, and 20.0%, respectively (p9 and ≤11, >11 and ≤13, and >13 were 64.0%, 44.1%, 34.4%, and 16.7%, respectively (p<0.05). Multivariate logistic regression analysis revealed that THRIVE+ORT score was an independent predictor of good outcome after adjusted for THRIVE score (odds ratio [OR], 1.367; 95% confidence interval [CI], 1.082-1.728) or after adjusted for ORT (OR, 1.517: 95% CI, 1.160-1.983). Conclusion: Our study showed that THRIVE+ORT score was associated with outcome that was independent from THRIVE score or ORT. This is the first report to suggest that patients with the higher THRIVE score require the shorter ORT for good outcome.

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