scholarly journals Hematoma Volume Measurement in Gradient Echo MRI Using Quantitative Susceptibility Mapping

Stroke ◽  
2013 ◽  
Vol 44 (8) ◽  
pp. 2315-2317 ◽  
Author(s):  
S. Wang ◽  
M. Lou ◽  
T. Liu ◽  
D. Cui ◽  
X. Chen ◽  
...  
Keyword(s):  
Volume Measurement ◽  
Susceptibility Mapping ◽  
Gradient Echo ◽  
Hematoma Volume ◽  
Quantitative Susceptibility Mapping

Abstract WP292: Quantitative Susceptibility Mapping for Reliably Measuring Hematoma Volume in Magnetic Resonance Imaging

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Shuo Wang ◽  
Min Lou ◽  
Tian Liu ◽  
xiaomei chen ◽  
Yi Wang
Keyword(s):  
Intracerebral Hemorrhage ◽  
T2 Mapping ◽  
Volume Measurement ◽  
Susceptibility Mapping ◽  
Gradient Echo ◽  
Hematoma Volume ◽  
Quantitative Susceptibility Mapping ◽  
Voxel Size ◽  
Magnitude Image ◽  
Imaging Parameters

Introduction T2* weighted gradient echo MRI has been increasingly recognized as a sensitive tool in detecting intracerebral hemorrhage. However, its blooming artifacts is highly dependent on imaging parameters including TE, field strength and voxel size, making it difficult to reliably estimate the hematoma volume, a key predictor of morbidity and mortality of hemorrhage. Recently, a novel quantitative susceptibility mapping (QSM) technology has been developed for processing gradient echo MRI data to map tissue susceptibility property without blooming artifacts and dependence on imaging parameters. Hypothesis We assessed the hypothesis that hematoma volume measurement on QSM is independent of imaging parameters, eliminating its TE dependence on gradient echo MRI. Method A retrospective image analysis of MRI was approved by our IRB with HIPPA compliance. We randomly selected 16 patients who underwent intracerebral hemorrhage MRI including a 3D multiecho T2*w sequence: 8-11 echoes with first echo TE/ echo spacing/ TR= 5/5/50 msec. Postprocessed images of gradient echo MRI included susceptibility weighted imaging (SWI), R2* (quantitative 1/T2* mapping), and QSM at various TEs. Hematoma volumes were measured from all these images. Results Linear regression of hematoma volume vs TE over all subjects showed substantial slopes for gradient echo magnitude (0.45±0.31 L/s), SWI (0.52±0.46) and R2* (0.39±0.30) but nearly zero slope for QSM (0.01±0.05). At TE=20 msec, hematoma volume on QSM was 0.80x that on gradient echo magnitude image (R2=0.99), and hematoma volume on CT is also 0.8x that on gradient echo magnitude image according to literature (Stroke 2008;39:2017-2020). Conclusion In conclusion, quantitative susceptibility mapping can provide reliable measurement of hematoma volume, independent echo time and similar to CT.

scholarly journals Multi-Echo Quantitative Susceptibility Mapping for Strategically Acquired Gradient Echo (STAGE) Imaging

2020 ◽  
Vol 14 ◽  
Author(s):  
Sara Gharabaghi ◽  
Saifeng Liu ◽  
Ying Wang ◽  
Yongsheng Chen ◽  
Sagar Buch ◽  
...  
Keyword(s):  
Susceptibility Mapping ◽  
Gradient Echo ◽  
Quantitative Susceptibility Mapping

scholarly journals Free breathing three-dimensional cardiac quantitative susceptibility mapping for differential cardiac chamber blood oxygenation – initial validation in patients with cardiovascular disease inclusive of direct comparison to invasive catheterization

2019 ◽  
Vol 21 (1) ◽  
Author(s):  
Yan Wen ◽  
Jonathan W. Weinsaft ◽  
Thanh D. Nguyen ◽  
Zhe Liu ◽  
Evelyn M. Horn ◽  
...  
Keyword(s):  
Free Breathing ◽  
Left Ventricular ◽  
Cardiac Performance ◽  
Blood Oxygenation ◽  
Susceptibility Mapping ◽  
Left Ventricular Ejection ◽  
Gradient Echo ◽  
Quantitative Susceptibility Mapping ◽  
Lv Dysfunction ◽  
Cine Cmr

Abstract Background Differential blood oxygenation between left (LV) and right ventricles (RV; ΔSaO2) is a key index of cardiac performance; LV dysfunction yields increased RV blood pool deoxygenation. Deoxyhemoglobin increases blood magnetic susceptibility, which can be measured using an emerging cardiovascular magnetic resonance (CMR) technique, Quantitative Susceptibility Mapping (QSM) – a concept previously demonstrated in healthy subjects using a breath-hold 2D imaging approach (2DBHQSM). This study tested utility of a novel 3D free-breathing QSM approach (3DNAVQSM) in normative controls, and validated 3DNAVQSM for non-invasive ΔSaO2 quantification in patients undergoing invasive cardiac catheterization (cath). Methods Initial control (n = 10) testing compared 2DBHQSM (ECG-triggered 2D gradient echo acquired at end-expiration) and 3DNAVQSM (ECG-triggered navigator gated gradient echo acquired in free breathing using a phase-ordered automatic window selection algorithm to partition data based on diaphragm position). Clinical testing was subsequently performed in patients being considered for cath, including 3DNAVQSM comparison to cine-CMR quantified LV function (n = 39), and invasive-cath quantified ΔSaO2 (n = 15). QSM was acquired using 3 T scanners; analysis was blinded to comparator tests (cine-CMR, cath). Results 3DNAVQSM generated interpretable QSM in all controls; 2DBHQSM was successful in 6/10. Among controls in whom both pulse sequences were successful, RV/LV susceptibility difference (and ΔSaO2) were not significantly different between 3DNAVQSM and 2DBHQSM (252 ± 39 ppb [17.5 ± 3.1%] vs. 211 ± 29 ppb [14.7 ± 2.0%]; p = 0.39). Acquisition times were 30% lower with 3DNAVQSM (4.7 ± 0.9 vs. 6.7 ± 0.5 min, p = 0.002), paralleling a trend towards lower LV mis-registration on 3DNAVQSM (p = 0.14). Among cardiac patients (63 ± 10y, 56% CAD) 3DNAVQSM was successful in 87% (34/39) and yielded higher ΔSaO2 (24.9 ± 6.1%) than in controls (p < 0.001). QSM-calculated ΔSaO2 was higher among patients with LV dysfunction as measured on cine-CMR based on left ventricular ejection fraction (29.4 ± 5.9% vs. 20.9 ± 5.7%, p < 0.001) or stroke volume (27.9 ± 7.5% vs. 22.4 ± 5.5%, p = 0.013). Cath measurements (n = 15) obtained within a mean interval of 4 ± 3 days from CMR demonstrated 3DNAVQSM to yield high correlation (r = 0.87, p < 0.001), small bias (− 0.1%), and good limits of agreement (±8.6%) with invasively measured ΔSaO2. Conclusion 3DNAVQSM provides a novel means of assessing cardiac performance. Differential susceptibility between the LV and RV is increased in patients with cine-CMR evidence of LV systolic dysfunction; QSM-quantified ΔSaO2 yields high correlation and good agreement with the reference of invasively-quantified ΔSaO2.

scholarly journals Quantitative assessment of microvasculopathy in arcAβ mice with USPIO-enhanced gradient echo MRI

2016 ◽  
Vol 36 (9) ◽  
pp. 1614-1624 ◽  
Author(s):  
Jan Klohs ◽  
Andreas Deistung ◽  
Giovanna D Ielacqua ◽  
Aline Seuwen ◽  
Diana Kindler ◽  
...  
Keyword(s):  
Magnetic Susceptibility ◽  
Iron Oxide ◽  
Superparamagnetic Iron Oxide ◽  
Brain Regions ◽  
Susceptibility Mapping ◽  
Amyloid Angiopathy ◽  
Gradient Echo ◽  
Quantitative Susceptibility Mapping ◽  
Focal Uptake

Magnetic resonance imaging employing administration of iron oxide-based contrast agents is widely used to visualize cellular and molecular processes in vivo. In this study, we investigated the ability of [Formula: see text] and quantitative susceptibility mapping to quantitatively assess the accumulation of ultrasmall superparamagnetic iron oxide (USPIO) particles in the arcAβ mouse model of cerebral amyloidosis. Gradient-echo data of mouse brains were acquired at 9.4 T after injection of USPIO. Focal areas with increased magnetic susceptibility and [Formula: see text] values were discernible across several brain regions in 12-month-old arcAβ compared to 6-month-old arcAβ mice and to non-transgenic littermates, indicating accumulation of particles after USPIO injection. This was concomitant with higher [Formula: see text] and increased magnetic susceptibility differences relative to cerebrospinal fluid measured in USPIO-injected compared to non-USPIO-injected 12-month-old arcAβ mice. No differences in [Formula: see text] and magnetic susceptibility were detected in USPIO-injected compared to non-injected 12-month-old non-transgenic littermates. Histological analysis confirmed focal uptake of USPIO particles in perivascular macrophages adjacent to small caliber cerebral vessels with radii of 2–8 µm that showed no cerebral amyloid angiopathy. USPIO-enhanced [Formula: see text] and quantitative susceptibility mapping constitute quantitative tools to monitor such functional microvasculopathies.

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