scholarly journals Short-Term Dose–Response Characteristics of 2-Iminobiotin Immediately Postinsult in the Neonatal Piglet After Hypoxia-Ischemia

Stroke ◽  
2013 ◽  
Vol 44 (3) ◽  
pp. 809-811 ◽  
Author(s):  
S. Tracey Bjorkman ◽  
Zoe Ireland ◽  
Xiyong Fan ◽  
Willem M. van der Wal ◽  
Kit C.B. Roes ◽  
...  
Keyword(s):  
Dose Response ◽  
Short Term ◽  
Response Characteristics ◽  
Neonatal Piglet ◽  
Hypoxia Ischemia

Short-Term Dose Response Characteristics of Acetazolamide in Man

1977 ◽  
Vol 95 (10) ◽  
pp. 1809-1812 ◽  
Author(s):  
B. R. Friedland ◽  
J. Mallonee ◽  
D. R. Anderson
Keyword(s):  
Dose Response ◽  
Short Term ◽  
Response Characteristics

Dose-response characteristics of an amorphous silicon EPID

2005 ◽  
Vol 32 (10) ◽  
pp. 3095-3105 ◽  
Author(s):  
Peter Winkler ◽  
Alfred Hefner ◽  
Dietmar Georg
Keyword(s):  
Amorphous Silicon ◽  
Dose Response ◽  
Response Characteristics

scholarly journals Dose-response analysis of epigenetic, metabolic, and apical endpoints after short-term exposure to experimental hepatotoxicants

2017 ◽  
Vol 109 ◽  
pp. 690-702 ◽  
Author(s):  
Isabelle R. Miousse ◽  
Lynea A. Murphy ◽  
Haixia Lin ◽  
Melissa R. Schisler ◽  
Jinchun Sun ◽  
...  
Keyword(s):  
Dose Response ◽  
Response Analysis ◽  
Short Term ◽  
Short Term Exposure

Varying the patterns and concentrations of gonadotrophin-releasing hormone stimulation does not alter the ratio of LH and FSH released from perifused sheep pituitary cells

1986 ◽  
Vol 109 (2) ◽  
pp. 155-161 ◽  
Author(s):  
J. E. A. McIntosh ◽  
R. P. McIntosh
Keyword(s):  
Dose Response ◽  
Dose Interval ◽  
Follicular Phase ◽  
Pituitary Cells ◽  
Ovulatory Cycle ◽  
Short Term ◽  
Releasing Hormone ◽  
Dissociated Cells ◽  
Gonadotrophin Releasing Hormone

ABSTRACT Our aim was to determine whether release of LH and FSH can be controlled differentially by the characteristics of applied signals of stimulatory gonadotrophin-releasing hormone (GnRH) alone, free of the effects of steroid feedback or other influences from the whole animal. The outputs of both gonadotrophins were significantly correlated (r≈0·90; P<0·0005) when samples of freshly dispersed sheep pituitary cells were perifused in columns for 7 h with medium containing a range of concentrations of GnRH in various patterns of pulses. Hormone released in response to the second, third and fourth pulses from every column was analysed in detail. Dose–response relationships for both LH and FSH were very similar when cells were stimulated with 5–8500 pmol GnRH/1 in 5-min pulses every hour. When GnRH was delivered in pulses at a maximally stimulating level, the outputs of both hormones increased similarly with increasing inter-pulse intervals. Efficiency of stimulation (release of gonadotrophin/unit stimulatory GnRH) decreased (was desensitized) with increasing pulse duration in the same way for both hormones. Thus, varying the dose, interval and duration of GnRH pulses did not alter the proportions of LH and FSH released in the short-term from freshly dissociated cells. However, the same cell preparations released more LH relative to FSH when treated with maximally stimulating levels of GnRH for 3 h in the presence of 10% serum from a sheep in the follicular phase of its ovulatory cycle compared with charcoal-treated serum. Because there was no gonadotrophin synthesis under the conditions used in vitro these results suggest that changes in the LH/FSH ratio seen in whole animals are more likely to result from differential clearance from the circulation, ovarian feedback at the pituitary, differential synthesis in intact tissue or another hormone influencing FSH secretion, rather than from differences in the mechanism of acute release controlled by GnRH. J. Endocr. (1986) 109, 155–161

Dose-Response and Efficacy of Ferric Citrate to Treat Hyperphosphatemia in Hemodialysis Patients: A Short-term Randomized Trial

2013 ◽  
Vol 61 (5) ◽  
pp. 759-766 ◽  
Author(s):  
Jamie P. Dwyer ◽  
Mohammed Sika ◽  
Gerald Schulman ◽  
Ingrid J. Chang ◽  
Michael Anger ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Dose Response ◽  
Hemodialysis Patients ◽  
Ferric Citrate ◽  
Short Term

Varying dose–response characteristics of different immunoassays and an in-vitro bioassay for FSH are responsible for changing ratios of biologically active to immunologically active FSH

1990 ◽  
Vol 127 (3) ◽  
pp. 523-532 ◽  
Author(s):  
F. Jockenhövel ◽  
S. A. Khan ◽  
E. Nieschlag
Keyword(s):  
Sertoli Cell ◽  
Dose Response ◽  
Serum Levels ◽  
Biologically Active ◽  
Testicular Function ◽  
In Vitro Bioassay ◽  
Great Caution ◽  
Response Characteristics ◽  
Infertile Men

ABSTRACT Serum FSH levels in fertile and infertile men were determined by applying the Sertoli cell in-vitro bioassay and six different immunoassays. Bioassay and immunoassay estimates were significantly correlated (r ranging from 0·78 to 0·86; P<0·01). On average, all immunoassays measured lower FSH concentrations in samples with low FSH levels and higher FSH concentrations in those with high FSH levels compared with the bioassay. Ratios of bioactivity to immunoreactivity (B/I) were highest in fertile men and lowest in men with severe disturbances of testicular function. Depending on which immunoassay was used these differences were either significant or only marginal. Dose–response characteristics for WHO FSH standard preparation 78/549, used in the bioassay as well as in the immunoassays, were different between immunoassays and the bioassay, suggesting that decreasing B/I ratios with increasing FSH serum levels were method-related and reflected different slopes of the dose–response characteristics of the assays, rather than being true changes in the molecular composition of FSH. The present investigation underlines the necessity of choosing the immunoassay used for comparison with the bioassay carefully and of validating the system in regard to parallelism between dose–response characteristics. B/I ratios must be interpreted with great caution and previous studies which report changing B/I ratios in various endocrine situations may have to be reevaluated. Journal of Endocrinology (1990) 127, 523–532

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