scholarly journals Extensive White Matter Hyperintensities May Increase Brain Volume in Cerebral Autosomal-Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

Stroke ◽  
2012 ◽  
Vol 43 (12) ◽  
pp. 3252-3257 ◽  
Author(s):  
Ming Yao ◽  
Eric Jouvent ◽  
Marco During ◽  
Ophélia Godin ◽  
Dominique Hervé ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Autosomal Dominant ◽  
Brain Volume

Vanishing White Matter Hyperintensities in CADASIL: A Case Report with Insight into Disease Mechanisms

2020 ◽  
Vol 78 (3) ◽  
pp. 907-910
Author(s):  
Eric Jouvent ◽  
Nassira Alili ◽  
Dominique Hervé ◽  
Hugues Chabriat
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Autosomal Dominant ◽  
Brain Area ◽  
Imaging Features ◽  
Water Influx ◽  
Disease Mechanisms ◽  
The Brain ◽  
Vanishing White Matter ◽  
Insight Into

In a woman with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) followed for 15 years, we observed magnetic resonance imaging white matter hyperintensities that vanished in the anterior temporal poles while the brain volume decreased unexpectedly. These imaging changes were transient and detected when the patient was being treated by valproic acid for stabilizing mood disturbances. This intriguing case supports that mechanisms underlying white matter hyperintensities can vary from one brain area to another and that important modifications of water influx into the brain tissue might be involved in some imaging features of CADASIL.

Slow-wave Sleep and MRI Markers of Brain Aging in a Community-based Sample

Neurology ◽  
2020 ◽  
pp. 10.1212/WNL.0000000000011377
Author(s):  
Andree-Ann Baril ◽  
Alexa S Beiser ◽  
Vincent Mysliwiec ◽  
Erlan Sanchez ◽  
Charles S DeCarli ◽  
...  
Keyword(s):  
White Matter ◽  
Slow Wave ◽  
White Matter Hyperintensities ◽  
Slow Wave Sleep ◽  
Brain Volume ◽  
Brain Aging ◽  
Brain Mri ◽  
Community Based ◽  
Brain Infarcts ◽  
Absolute Duration

Objective:To test the hypothesis that reduced slow-wave sleep, or N3 sleep, which is thought to underlie the restorative functions of sleep, is associated with MRI markers of brain aging, we evaluated this relationship in the community-based Framingham Heart Study Offspring cohort using polysomnography and brain MRI.Methods:We studied 492 participants (58.8 ± 8.8 years, 49.4% male) free of neurological diseases who completed a brain MRI scan and in-home overnight polysomnography to assess slow-wave sleep (absolute duration and percentage of total sleep). Volumes of total brain, total cortical, frontal cortical, subcortical gray matter, hippocampus, and white matter hyperintensities were investigated as a percentage of intracranial volume and the presence of covert brain infarcts was evaluated. Linear and logistic regression models were adjusted for age, age squared, sex, time interval between polysomnography and MRI (3.3 ± 1.0 years), APOE4 carrier status, stroke risk factors, sleeping pill use, body mass index and depression.Results:Less slow-wave sleep was associated with lower cortical brain volume (absolute duration, β[standard error]: 0.20[0.08], p=0.015; percentage, 0.16[0.08], p=0.044), lower subcortical brain volume (percentage, 0.03[0.02], p=0.034), and higher white matter hyperintensities volume (absolute duration, -0.12[0.05], p=0.010; percentage -0.10[0.04], p=0.033). Slow-wave sleep duration was not associated with hippocampal volume or the presence of covert brain infarcts.Conclusion:Loss of slow-wave sleep might facilitate accelerated brain aging, as evidence by its association with MRI markers suggestive of brain atrophy and injury. Alternatively, subtle injuries and accelerated aging might reduce the ability of the brain to produce slow-wave sleep.

P3-128: Differences in MRI measures of brain volume, white matter hyperintensities and infarcts in Chinese: The Shanghai Community Brain Health Initiative (SCOBHI)

2009 ◽  
Vol 5 (4S_Part_12) ◽  
pp. P382-P382
Author(s):  
Charles DeCarli ◽  
Amy Borenstein ◽  
Jing He ◽  
Ding Ding ◽  
Dong Young Lee ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Brain Volume ◽  
Brain Health ◽  
Health Initiative

scholarly journals Independent and interactive effects of blood pressure and cardiac function on brain volume and white matter hyperintensities in heart failure

2013 ◽  
Vol 7 (5) ◽  
pp. 336-343 ◽  
Author(s):  
Michael L. Alosco ◽  
Adam M. Brickman ◽  
Mary Beth Spitznagel ◽  
Erica Y. Griffith ◽  
Atul Narkhede ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
White Matter ◽  
Cardiac Function ◽  
White Matter Hyperintensities ◽  
Brain Volume ◽  
Interactive Effects

Relation of a Socioeconomic Index with Cognitive Function and Neuroimaging in Hypertensive Individuals

2021 ◽  
pp. 1-12
Author(s):  
Regina Silva Paradela ◽  
Naomi Vidal Ferreira ◽  
Mariana Penteado Nucci ◽  
Brenno Cabella ◽  
Luiza Menoni Martino ◽  
...  
Keyword(s):  
Cognitive Function ◽  
White Matter ◽  
Cognitive Performance ◽  
White Matter Hyperintensities ◽  
Social Inequalities ◽  
Parietal Lobe ◽  
Brain Volume ◽  
Linear Regression Models ◽  
Socioeconomic Index ◽  
The Relationship

Background: Socioeconomic factors are important contributors to brain health. However, data from developing countries (where social inequalities are the most prominent) are still scarce, particularly about hypertensive individuals. Objective: To evaluate the relationship between socioeconomic index, cognitive function, and cortical brain volume, as well as determine whether white matter hyperintensities are mediators of the association of the socioeconomic index with cognitive function in hypertensive individuals. Methods: We assessed 92 hypertensive participants (mean age = 58±8.6 years, 65.2%female). Cognitive evaluation and neuroimaging were performed and clinical and sociodemographic data were collected using questionnaires. A socioeconomic index was created using education, income, occupation (manual or non-manual work), and race. The associations of the socioeconomic index with cognitive performance and brain volume were investigated using linear regression models adjusted for age, sex, time of hypertension since diagnosis, and comorbidities. A causal mediation analysis was also conducted. Results: Better socioeconomic status was associated with better visuospatial ability, executive function, and global cognition. We found associations between a better socioeconomic index and a higher parietal lobe volume. White matter hyperintensities were also not mediators in the relationship between the socioeconomic index and cognitive performance. Conclusion: Socioeconomic disadvantages are associated with worse cognitive performance and brain volume in individuals with hypertension.

scholarly journals IC-P-082: Differences in MRI measures of brain volume, white matter hyperintensities and infarcts in Chinese: The Shanghai Community Brain Health Initiative (SCOBHI)

2009 ◽  
Vol 5 (4S_Part_1) ◽  
pp. P37-P38
Author(s):  
Charles DeCarli ◽  
Amy Borenstein ◽  
Jing He ◽  
Ding Ding ◽  
Dong Young Lee ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Brain Volume ◽  
Brain Health ◽  
Health Initiative

Brain volume and white matter hyperintensities as determinants of cerebral blood flow in Alzheimer's disease

2014 ◽  
Vol 35 (12) ◽  
pp. 2665-2670 ◽  
Author(s):  
Marije R. Benedictus ◽  
Maja A.A. Binnewijzend ◽  
Joost P.A. Kuijer ◽  
Martijn D. Steenwijk ◽  
Adriaan Versteeg ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Brain Volume
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