scholarly journals Amyloid-β Contributes to Blood–Brain Barrier Leakage in Transgenic Human Amyloid Precursor Protein Mice and in Humans With Cerebral Amyloid Angiopathy

Stroke ◽  
2012 ◽  
Vol 43 (2) ◽  
pp. 514-523 ◽  
Author(s):  
Anika M.S. Hartz ◽  
Björn Bauer ◽  
Emma L.B. Soldner ◽  
Andrea Wolf ◽  
Sandra Boy ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Blood Brain Barrier ◽  
Cerebral Amyloid Angiopathy ◽  
Amyloid Β ◽  
Precursor Protein ◽  
Brain Barrier ◽  
Amyloid Angiopathy ◽  
Blood Brain ◽  
Cerebral Amyloid

Cerebral Amyloid Angiopathy and Blood-Brain Barrier Dysfunction

2020 ◽  
pp. 107385842095481
Author(s):  
Monica Gireud-Goss ◽  
Alexis F. Mack ◽  
Louise D. McCullough ◽  
Akihiko Urayama
Keyword(s):  
Blood Brain Barrier ◽  
Cerebral Amyloid Angiopathy ◽  
Amyloid Β ◽  
Brain Barrier ◽  
Amyloid Angiopathy ◽  
Barrier Dysfunction ◽  
Vessel Occlusion ◽  
Main Hypothesis ◽  
Blood Brain ◽  
Cerebral Amyloid

Cerebral hemorrhage, a devastating subtype of stroke, is often caused by hypertension and cerebral amyloid angiopathy (CAA). Pathological evidence of CAA is detected in approximately half of all individuals over the age of 70 and is associated with cortical microinfarcts and cognitive impairment. The underlying pathophysiology of CAA is characterized by accumulation of pathogenic amyloid β (Aβ) fragments of amyloid precursor protein in the cerebral vasculature. Vascular deposition of Aβ damages the vessel wall, results in blood-brain barrier (BBB) leakiness, vessel occlusion or rupture, and leads to hemorrhages and decreased cerebral blood flow that negatively affects vessel integrity and cognitive function. Currently, the main hypothesis surrounding the mechanism of CAA pathogenesis is that there is an impaired clearance of Aβ peptides, which includes compromised perivascular drainage as well as dysfunction of BBB transport. Also, the immune response in CAA pathogenesis plays an important role. Therefore, the mechanism by which Aβ vascular deposition occurs is crucial for our understanding of CAA pathogenesis and for the development of potential therapeutic options.

scholarly journals Blood-Brain Barrier Leakage and Microvascular Lesions in Cerebral Amyloid Angiopathy

Stroke ◽  
2019 ◽  
Vol 50 (2) ◽  
pp. 328-335 ◽  
Author(s):  
Whitney M. Freeze ◽  
Brian J. Bacskai ◽  
Matthew P. Frosch ◽  
Heidi I.L. Jacobs ◽  
Walter H. Backes ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Cerebral Amyloid Angiopathy ◽  
Brain Barrier ◽  
Amyloid Angiopathy ◽  
Blood Brain ◽  
Cerebral Amyloid

P2-479: BLOOD-BRAIN BARRIER LEAKAGE AND MICROVASCULAR LESIONS IN CEREBRAL AMYLOID ANGIOPATHY: A POSTMORTEM MRI AND HISTOPATHOLOGY STUDY

2006 ◽  
Vol 14 (7S_Part_16) ◽  
pp. P909-P909
Author(s):  
Whitney M. Freeze ◽  
Steven M. Greenberg ◽  
Matthew P. Frosch ◽  
Heidi I.L. Jacobs ◽  
Walter H. Backes ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Cerebral Amyloid Angiopathy ◽  
Brain Barrier ◽  
Amyloid Angiopathy ◽  
Postmortem Mri ◽  
Blood Brain ◽  
Cerebral Amyloid

IC-P-051: BLOOD-BRAIN BARRIER LEAKAGE AND MICROVASCULAR LESIONS IN CEREBRAL AMYLOID ANGIOPATHY: A POSTMORTEM MRI AND HISTOPATHOLOGY STUDY

2006 ◽  
Vol 14 (7S_Part_1) ◽  
pp. P50-P50
Author(s):  
Whitney M. Freeze ◽  
Steven M. Greenberg ◽  
Matthew P. Frosch ◽  
Heidi IL. Jacobs ◽  
Walter H. Backes ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Cerebral Amyloid Angiopathy ◽  
Brain Barrier ◽  
Amyloid Angiopathy ◽  
Postmortem Mri ◽  
Blood Brain ◽  
Cerebral Amyloid

scholarly journals The effects of cerebral amyloid angiopathy on integrity of the blood-brain barrier

2018 ◽  
Vol 70 ◽  
pp. 70-77 ◽  
Author(s):  
Shino Magaki ◽  
Zhaoyi Tang ◽  
Spencer Tung ◽  
Christopher K. Williams ◽  
Darrick Lo ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Cerebral Amyloid Angiopathy ◽  
Brain Barrier ◽  
Amyloid Angiopathy ◽  
Blood Brain ◽  
Cerebral Amyloid
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