scholarly journals Annexin A2: A Tissue Plasminogen Activator Amplifier for Thrombolytic Stroke Therapy

Stroke ◽  
2010 ◽  
Vol 41 (10, Supplement 1) ◽  
pp. S54-S58 ◽  
Author(s):  
X. Fan ◽  
Z. Yu ◽  
J. Liu ◽  
N. Liu ◽  
K. A. Hajjar ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Annexin A2 ◽  
Stroke Therapy ◽  
Tissue Plasminogen

scholarly journals Annexin A2 Egress during Calcium-Regulated Exocytosis in Neuroendocrine Cells

Cells ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 2059 ◽  
Author(s):  
Marion Gabel ◽  
Cathy Royer ◽  
Tamou Thahouly ◽  
Valérie Calco ◽  
Stéphane Gasman ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Chromaffin Cells ◽  
Spatial Organization ◽  
Lipid Binding ◽  
Annexin A2 ◽  
Neuroendocrine Cells ◽  
Outer Face ◽  
Tissue Plasminogen

Annexin A2 (AnxA2) is a calcium- and lipid-binding protein involved in neuroendocrine secretion where it participates in the formation and/or stabilization of lipid micro-domains required for structural and spatial organization of the exocytotic machinery. We have recently described that phosphorylation of AnxA2 on Tyr23 is critical for exocytosis. Considering that Tyr23 phosphorylation is known to promote AnxA2 externalization to the outer face of the plasma membrane in different cell types, we examined whether this phenomenon occurred in neurosecretory chromaffin cells. Using immunolabeling and biochemical approaches, we observed that nicotine stimulation triggered the egress of AnxA2 to the external leaflets of the plasma membrane in the vicinity of exocytotic sites. AnxA2 was found co-localized with tissue plasminogen activator, previously described on the surface of chromaffin cells following secretory granule release. We propose that AnxA2 might be a cell surface tissue plasminogen activator receptor for chromaffin cells, thus playing a role in autocrine or paracrine regulation of exocytosis.

scholarly journals Annexin A2 acts as scaffolding receptor for plasminogen and tissue plasminogen activator in renal epithelia

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Henriette Josephine Kaminski ◽  
Christin Dathe ◽  
Hanna Neymeyer ◽  
Daniel Brand ◽  
Tanja Loof ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Annexin A2 ◽  
Renal Epithelia ◽  
Tissue Plasminogen
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