scholarly journals Key Role of CD36 in Toll-Like Receptor 2 Signaling in Cerebral Ischemia

Stroke ◽  
2010 ◽  
Vol 41 (5) ◽  
pp. 898-904 ◽  
Author(s):  
Takato Abe ◽  
Munehisa Shimamura ◽  
Katherine Jackman ◽  
Hitomi Kurinami ◽  
Josef Anrather ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

Role of toll-like receptor 2 and 4 gene polymorphisms in the development of allergic diseases with increased IgE levels

2012 ◽  
Vol 46 (6) ◽  
pp. 379-383 ◽  
Author(s):  
N. L. Kutsenko ◽  
O. V. Izmailova ◽  
L. E. Vesnina ◽  
I. P. Kaidashev
Keyword(s):  
Gene Polymorphisms ◽  
Allergic Diseases ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

Role of Toll-like receptor 2 in the immune response against hepadnaviral infection

2012 ◽  
Vol 57 (3) ◽  
pp. 522-528 ◽  
Author(s):  
Xiaoyong Zhang ◽  
Zhiyong Ma ◽  
Hongyan Liu ◽  
Jia Liu ◽  
Zhongji Meng ◽  
...  
Keyword(s):  
Immune Response ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

1153 – Critical Role of Toll-Like Receptor 2 in Mediating Serotonin Production in Gut

2019 ◽  
Vol 156 (6) ◽  
pp. S-247
Author(s):  
Yun Han Kwon ◽  
Huaqing Wang ◽  
Varun Dewan ◽  
Saad Syed ◽  
Michelle E. Fontes ◽  
...  
Keyword(s):  
Critical Role ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

scholarly journals Interactions between Yersinia pestis V-antigen (LcrV) and human Toll-like receptor 2 (TLR2) in a modelled protein complex and potential mechanistic insights

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Tiandi Wei ◽  
Jing Gong ◽  
Guojing Qu ◽  
Mingyu Wang ◽  
Hai Xu
Keyword(s):  
Immune Response ◽  
Yersinia Pestis ◽  
Mechanistic Model ◽  
White Blood Cells ◽  
Dynamics Simulation ◽  
Structure Model ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2 ◽  
V Antigen

Abstract Background Yersinia pestis, the etiological pathogen of plague, is capable of repressing the immune response of white blood cells to evade phagocytosis. The V-antigen (LcrV) was found to be involved in this process by binding to human Toll-like Receptor 2 (TLR2). The detailed mechanism behind this LcrV and TLR2 mediated immune response repression, however, is yet to be fully elucidated due to the lack of structural information. Results In this work, with protein structure modelling, we were able to construct a structure model of the heterotetramer of Y. pestis LcrV and human TLR2. Molecular dynamics simulation suggests the stability of this structure in aquatic environment. The LcrV model has a dumbbell-like structure with two globule domains (G1 at N-terminus and G2 away from membrane) connected with a coiled-coil linker (CCL) domain. The two horseshoe-shape TLR2 subunits form a V-shape structure, are not in direct contact with each other, and are held together by the LcrV homodimer. In this structure model, both the G1 and CCL domains are involved in the formation of LcrV homodimer, while all three domains are involved in LcrV-TLR2 binding. A mechanistic model was proposed based on this heterotetrameric structure model: The LcrV homodimer separates the TLR2 subunits to inhibit the dimerization of TLR2 and subsequent signal transfer for immune response; while LcrV could also inhibit the formation of heterodimers of TLR2 with other TLRs, and leads to immune response repression. Conclusions A heterotetrameric structure of Y. pestis LcrV and human TLR2 was modelled in this work. Analysis of this modelled structure showed its stability in aquatic environments and the role of LcrV domains and residues in protein-protein interaction. A mechanistic model for the role of LcrV in Y. pestis pathogenesis is raised based on this heterotetrameric structure model. This work provides a hypothesis of LcrV function, with which further experimental validation may elucidate the role of LcrV in human immune response repression.

Role of toll-like receptor 2 in ischemic demyelination and oligodendrocyte death

2014 ◽  
Vol 35 (7) ◽  
pp. 1643-1653 ◽  
Author(s):  
Jun Young Choi ◽  
Yuexian Cui ◽  
Young Mi Kang ◽  
Jang-Hee Kim ◽  
Sung Joong Lee ◽  
...  
Keyword(s):  
Toll Like Receptor ◽  
Toll Like Receptor 2

scholarly journals The Role of Toll-Like Receptor 2 in Inflammation and Fibrosis during Progressive Renal Injury

PLoS ONE ◽  
2009 ◽  
Vol 4 (5) ◽  
pp. e5704 ◽  
Author(s):  
Jaklien C. Leemans ◽  
Loes M. Butter ◽  
Wilco P. C. Pulskens ◽  
Gwendoline J. D. Teske ◽  
Nike Claessen ◽  
...  
Keyword(s):  
Renal Injury ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

scholarly journals Limited role of the Toll-like receptor-2 in resistance to Mycobacterium avium

Immunology ◽  
2004 ◽  
Vol 111 (2) ◽  
pp. 179-185 ◽  
Author(s):  
M. Salome Gomes ◽  
Manuela Florido ◽  
Joao V. Cordeiro ◽  
C. Miguel Teixeira ◽  
Osamu Takeuchi ◽  
...  
Keyword(s):  
Mycobacterium Avium ◽  
Toll Like Receptor ◽  
Limited Role ◽  
Toll Like Receptor 2

scholarly journals Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography

2016 ◽  
Vol 36 (4) ◽  
pp. 702-708 ◽  
Author(s):  
Ana Moraga ◽  
Vanessa Gómez-Vallejo ◽  
María Isabel Cuartero ◽  
Boguslaw Szczupak ◽  
Eneko San Sebastián ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Positron Emission Tomography ◽  
Cerebral Ischemia ◽  
Emission Tomography ◽  
Toll Like Receptor ◽  
Resonance Imaging ◽  
Toll Like Receptor 4 ◽  
Positron Emission ◽  
Neuroimaging Techniques

The influence of toll-like receptor 4 on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques. For this purpose, we performed magnetic resonance imaging and positron emission tomography with 3′-deoxy-3′-[18F]fluorothymidine and [11C]PK11195 at 2, 7, and 14 days following cerebral ischemia in TLR4+/+ and TLR4−/− mice. MRI showed similar infarction volumes in both groups. Despite this, positron emission tomography with 3′-deoxy-3′-[18F]fluorothymidine and [11C]PK11195 evidenced an increase of neurogenesis and a decrease of inflammation in TLR4−/− mice after ischemia. These results evidence the versatility of neuroimaging techniques to monitor the role of toll-like receptor 4 after cerebral ischemia.

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