scholarly journals Cyclo-Oxygenase-2 Mediates Hyperbaric Oxygen Preconditioning-Induced Neuroprotection in the Mouse Model of Surgical Brain Injury

Stroke ◽  
2009 ◽  
Vol 40 (9) ◽  
pp. 3139-3142 ◽  
Author(s):  
Vikram Jadhav ◽  
Robert P. Ostrowski ◽  
Wenni Tong ◽  
Brenden Matus ◽  
Rachel Jesunathadas ◽  
...  
Keyword(s):  
Brain Injury ◽  
Mouse Model ◽  
Hyperbaric Oxygen ◽  
Surgical Brain Injury ◽  
Hyperbaric Oxygen Preconditioning

scholarly journals Hyperbaric oxygen preconditioning attenuates brain injury after intracerebral hemorrhage by regulating microglia polarization in rats

2019 ◽  
Vol 25 (10) ◽  
pp. 1126-1133 ◽  
Author(s):  
Ming Wang ◽  
Lin Cheng ◽  
Zhong‐Liang Chen ◽  
Rajneesh Mungur ◽  
Shan‐Hu Xu ◽  
...  
Keyword(s):  
Brain Injury ◽  
Intracerebral Hemorrhage ◽  
Hyperbaric Oxygen ◽  
Microglia Polarization ◽  
Hyperbaric Oxygen Preconditioning

scholarly journals Acute treatment with TrkB agonist LM22A-4 confers neuroprotection and preserves myelin integrity in a mouse model of pediatric traumatic brain injury

2021 ◽  
Vol 339 ◽  
pp. 113652
Author(s):  
Jessica L. Fletcher ◽  
Larissa K. Dill ◽  
Rhiannon J. Wood ◽  
Sharon Wang ◽  
Kate Robertson ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mouse Model ◽  
Acute Treatment ◽  
Pediatric Traumatic Brain Injury

scholarly journals Strain-Related Differences in Mouse Neonatal Hypoxia-Ischemia

2018 ◽  
Vol 40 (5-6) ◽  
pp. 490-496 ◽  
Author(s):  
R. Ann Sheldon ◽  
Christine Windsor ◽  
Donna M. Ferriero
Keyword(s):  
Brain Injury ◽  
Mouse Model ◽  
Strain Differences ◽  
Artery Occlusion ◽  
Carotid Artery Occlusion ◽  
Cresyl Violet ◽  
Posterior Cortex ◽  
Carotid Ligation ◽  
Hypoxia Ischemia ◽  
Cd1 Mice

Neonatal hypoxic-ischemic brain injury is commonly studied by means of the Vannucci procedure in mice or rats (unilateral common carotid artery occlusion followed by hypoxia). Previously, we modified the postnatal day 7 (P7) rat procedure for use in mice, and later demonstrated that genetic strain strongly influences the degree of brain injury in the P7 mouse model of hypoxia-ischemia (HI). Recently, the P9 or P10 mouse brain was recognized as the developmental equivalent of a term neonatal human brain, rather than P7. Consequently, the Vannucci procedure has again been modified, and a commonly used protocol employs 10% oxygen for 50 min in C57Bl/6 mice. Strain differences have yet to be described for the P9/P10 mouse model. In order to determine if the strain differences we previously reported in the P7 mouse model are present in the P9 model, we compared 2 commonly used strains, CD1 and C57Bl/6J, in both the P7 (carotid ligation [in this case, right] followed by exposure to 8% oxygen for 30 min) and P9 (carotid ligation [in this case left] followed by exposure to 10% oxygen) models of HI. Experiments using the P7 model were performed in 2001–2012 and those using the P9 model were performed in 2012–2016. Five to seven days after the HI procedure, mice were perfused with 4% paraformaldehyde, their brains were sectioned on a Vibratome (50 µm) and alternate sections were stained with Perl’s iron stain or cresyl violet. Brain sections were examined microscopically and scored for the degree of injury. Since brains in the P7 group had been scored previously with a slightly different system, they were reanalyzed using our current scoring system which scores injury in 11 regions: the anterior, middle, and posterior cortex; the anterior, middle, and posterior striatum; CA1, CA2, CA3, and the dentate gyrus of the hippocampus and thalamus, on a scale from 0 (none) to 3 (cystic infarct) for a total score of 0–33. Brains in the P9 group were scored with the same system. Given the same insult, the P7 CD1 mice had greater injury than the C57Bl/6J mice, which agrees with our previous findings. The P9 CD1 mice also had greater injury than the C57Bl/6J mice. This study confirms that CD1 mice are more susceptible to injury than C57Bl/6J mice and that strain selection is important when using mouse models of HI.

scholarly journals Peroxynitrite-Mediated Protein Nitration and Lipid Peroxidation in a Mouse Model of Traumatic Brain Injury

2004 ◽  
Vol 21 (1) ◽  
pp. 9-20 ◽  
Author(s):  
Edward D. Hall ◽  
Megan R. Detloff ◽  
Kjell Johnson ◽  
Nancy C. Kupina
Keyword(s):  
Traumatic Brain Injury ◽  
Lipid Peroxidation ◽  
Brain Injury ◽  
Mouse Model ◽  
Protein Nitration
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