scholarly journals Cerebral Blood Flow Measurement in Children With Sickle Cell Disease Using Continuous Arterial Spin Labeling at 3.0-Tesla MRI

Stroke ◽  
2009 ◽  
Vol 40 (3) ◽  
pp. 795-800 ◽  
Author(s):  
Xandra W. van den Tweel ◽  
Aart J. Nederveen ◽  
Charles B. L. M. Majoie ◽  
Johanna H. van der Lee ◽  
Laetitia Wagener-Schimmel ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Sickle Cell Disease ◽  
Arterial Spin Labeling ◽  
Flow Measurement ◽  
Spin Labeling ◽  
Blood Flow Measurement ◽  
Cell Disease ◽  
3.0 Tesla ◽  
Continuous Arterial Spin Labeling

scholarly journals Inverse correlation between cerebral blood flow measured by continuous arterial spin-labeling (CASL) MRI and neurocognitive function in children with sickle cell anemia (SCA)

Blood ◽  
2006 ◽  
Vol 108 (1) ◽  
pp. 379-381 ◽  
Author(s):  
John J. Strouse ◽  
Christiane S. Cox ◽  
Elias R. Melhem ◽  
Hanzhang Lu ◽  
Michael A. Kraut ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Arterial Spin Labeling ◽  
Complete Blood Count ◽  
Spin Labeling ◽  
Neurocognitive Impairment ◽  
Continuous Arterial Spin Labeling ◽  
L 14

Overt stroke, clinically “silent” cerebral infarct, and neurocognitive impairment are frequent complications of sickle cell anemia (SCA). Current imaging techniques have limited sensitivity and specificity to identify children at risk for neurocognitive impairment. We prospectively evaluated 24 children with SCA with a neurologic exam, complete blood count, transcranial Doppler ultrasound (TCD), measurement of intelligence quotient (IQ), and magnetic resonance imaging (MRI) with measurement of cerebral blood flow (CBF) using continuous arterial spin-labeling (CASL) MRI. Average CBF to gray matter was 112 ± 36 mL/100 g/min. We identified a strong inverse relationship between performance IQ and CBF (-1.5 points per 10 mL/100 g/min increase in CBF, P = .013). Elevated steady-state white blood cell count (≥ 14 × 109/L [14 000/μL]) was associated with lower full scale IQ (86 ± 9 vs 99 ± 10, P = .005). CASL MRI may identify children with neurocognitive impairment, before damage is evident by structural MRI or TCD. (Blood. 2006;108:379-381)

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