scholarly journals Genetic Variation in the Lymphotoxin-Alpha Pathway and the Risk of Ischemic Stroke in European Populations

Stroke ◽  
2009 ◽  
Vol 40 (3) ◽  
pp. 970-972 ◽  
Author(s):  
Tobias Freilinger ◽  
Steve Bevan ◽  
Stephan Ripke ◽  
Andreas Gschwendtner ◽  
Peter Lichtner ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Ischemic Stroke ◽  
Lymphotoxin Alpha ◽  
European Populations

scholarly journals Genetic variation at the IGF1 locus shows association with post-stroke outcome and to circulating IGF1

2013 ◽  
Vol 169 (6) ◽  
pp. 759-765 ◽  
Author(s):  
N David Åberg ◽  
Sandra Olsson ◽  
Daniel Åberg ◽  
Katarina Jood ◽  
Tara M Stanne ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Ischemic Stroke ◽  
Stroke Severity ◽  
Stroke Outcome ◽  
Nucleotide Polymorphisms ◽  
Post Stroke ◽  
Index Stroke ◽  
Genetic Impact ◽  
Major Allele ◽  
Community Controls

ObjectiveIn humans, serum IGF1 (s-IGF1) is associated with outcome after ischemic stroke (IS). Therefore variation at the IGF1 locus could also associate with both IS and s-IGF1. We investigated whether genetic variation at the IGF1 locus is associated with i) s-IGF1, ii) IS occurrence, iii) IS severity, and iv) post-stroke outcome.Design/methodsPatients (n=844; 66% males, mean age 56 years) and community controls (n=668) were included from the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS). Post-stroke outcome was evaluated with the modified Rankin Scale at 3 and 24 months after index stroke, and baseline stroke severity with the Scandinavian Stroke Scale. s-IGF1 was determined in patients and after random selection in 40 of the controls.ResultsEleven single nucleotide polymorphisms (SNPs) were selected in the IGF1 gene. In healthy controls the major allele of rs7136446 was associated with higher s-IGF1, whereas in patients no such association was found. No SNP was associated with IS, nor with stroke severity. After multivariate correction for presence of diabetes, smoking, and hypertension, the major allele of rs7136446 was associated with favorable functional outcome 24-months post-stroke (odds ratio 1.46; 95% CI 1.09–1.96).ConclusionVariation in rs7136446 of the IGF1 gene associates with post-stroke outcome in relatively young IS patients. Also, rs7136446 associates with s-IGF1 in controls but not in IS, which indicates that IS perturbs a normal genetic impact on s-IGF1 levels.

No evidence for an association between genetic variation at the SERPINI1 locus and ischemic stroke

2011 ◽  
Vol 258 (10) ◽  
pp. 1885-1887 ◽  
Author(s):  
A. Tjärnlund-Wolf ◽  
S. Olsson ◽  
K. Jood ◽  
C. Blomstrand ◽  
C. Jern
Keyword(s):  
Genetic Variation ◽  
Ischemic Stroke

Common genetic variation near MC4R is associated with eating behaviour patterns in European populations

2009 ◽  
Vol 33 (3) ◽  
pp. 373-378 ◽  
Author(s):  
F Stutzmann ◽  
S Cauchi ◽  
E Durand ◽  
C Calvacanti-Proença ◽  
M Pigeyre ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Eating Behaviour ◽  
Common Genetic Variation ◽  
European Populations

scholarly journals Association between genetic variation at the ADAMTS13 locus and ischemic stroke

2009 ◽  
Vol 7 (12) ◽  
pp. 2147-2148 ◽  
Author(s):  
E. HANSON ◽  
K. JOOD ◽  
S. NILSSON ◽  
C. BLOMSTRAND ◽  
C. JERN
Keyword(s):  
Genetic Variation ◽  
Ischemic Stroke

ID: 184 An increased risk of ischemic stroke is related to activated TAFI levels but not to genetic variation

2006 ◽  
Vol 4 (s1) ◽  
pp. 204-204
Author(s):  
C. Jern ◽  
C. Ladenvall ◽  
A. Gils ◽  
K. Jood ◽  
P. Declerck ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Ischemic Stroke ◽  
Increased Risk
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