scholarly journals Effects of Initiation and Acute Withdrawal of Statins on the Neurovascular Coupling Mechanism in Healthy, Normocholesterolemic Humans

Stroke ◽  
2007 ◽  
Vol 38 (12) ◽  
pp. 3193-3197 ◽  
Author(s):  
Bernhard Rosengarten ◽  
Dieter Auch ◽  
Manfred Kaps
Keyword(s):  
Neurovascular Coupling ◽  
Coupling Mechanism ◽  
Acute Withdrawal

scholarly journals Effects of Acute Hyperhomocysteinemia on the Neurovascular Coupling Mechanism in Healthy Young Adults

Stroke ◽  
2003 ◽  
Vol 34 (2) ◽  
pp. 446-451 ◽  
Author(s):  
B. Rosengarten ◽  
S. Osthaus ◽  
D. Auch ◽  
M. Kaps
Keyword(s):  
Young Adults ◽  
Neurovascular Coupling ◽  
Coupling Mechanism

scholarly journals Multimodal Detection for Cryptogenic Epileptic Seizures Based on Combined Micro Sensors

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Zhitian Shen ◽  
Yang Jiao ◽  
Yiwen Xu ◽  
Wei Shi ◽  
Chen Yang ◽  
...  
Keyword(s):  
Blood Concentration ◽  
Neurovascular Coupling ◽  
Depth Information ◽  
Coupling Mechanism ◽  
Concentration Change ◽  
Electrical Signals ◽  
In Vivo Experiments ◽  
Concentration Changes ◽  
Phantom Experiments

The cryptogenic epilepsy of the neocortex is a disease in which the seizure is accompanied by intense cerebral nerve electrical activities but the lesions are not observed. It is difficult to locate disease foci. Electrocorticography (ECoG) is one of the gold standards in seizure focus localization. This method detects electrical signals, and its limitations are inadequate resolution which is only 10 mm and lack of depth information. In order to solve these problems, our new method with implantable micro ultrasound transducer (MUT) and photoplethysmogram (PPG) device detects blood changes to achieve higher resolution and provide depth information. The basis of this method is the neurovascular coupling mechanism, which shows that intense neural activity leads to sufficient cerebral blood volume (CBV). The neurovascular coupling mechanism established the relationship between epileptic electrical signals and CBV. The existence of mechanism enables us to apply our new methods on the basis of ECoG. Phantom experiments and in vivo experiments were designed to verify the proposed method. The first phantom experiments designed a phantom with two channels at different depths, and the MUT was used to detect the depth where the blood concentration changed. The results showed that the MUT detected the blood concentration change at the depth of 12 mm, which is the position of the second channel. In the second phantom experiments where a PPG device and MUT were used to monitor the change of blood concentration in a thick tube, the results showed that the trend of superficial blood concentration change provided by the PPG device is the same as that provided by the MUT within the depth of 2.5 mm. Finally, in the verification of in vivo experiments, the blood concentration changes on the surface recorded by the PPG device and the changes at a certain depth recorded by the MUT all matched the seizure status shown by ECoG. These results confirmed the effectiveness of the combined micro sensors.

The neural basis of the hemodynamic response nonlinearity in human primary visual cortex: Implications for neurovascular coupling mechanism

NeuroImage ◽  
2006 ◽  
Vol 32 (2) ◽  
pp. 616-625 ◽  
Author(s):  
Xiaohong Wan ◽  
Jorge Riera ◽  
Kazuki Iwata ◽  
Makoto Takahashi ◽  
Toshio Wakabayashi ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Neurovascular Coupling ◽  
Hemodynamic Response ◽  
Coupling Mechanism ◽  
Neural Basis

Negative neurovascular coupling during anoxic depolarization and peri-infarct spreading depressions in acute focal cerebral ischemia in mice

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S425-S425
Author(s):  
Cenk Ayata ◽  
Hwa Kyoung Shin ◽  
Phillip Jones ◽  
Andrew K Dunn ◽  
David A Boas ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Neurovascular Coupling ◽  
Anoxic Depolarization

EVALUATION OF TISSUE STEROID BINDING IN VITRO

1971 ◽  
Vol 68 (1_Suppl) ◽  
pp. S223-S246 ◽  
Author(s):  
C. R. Wira ◽  
H. Rochefort ◽  
E. E. Baulieu
Keyword(s):  
Protein Binding ◽  
Binding Sites ◽  
Experimental System ◽  
Specific Protein ◽  
Coupling Mechanism ◽  
Target Tissue ◽  
Protein Binding Sites ◽  
Definition Of ◽  
Hormone Specificity

ABSTRACT The definition of a RECEPTOR* in terms of a receptive site, an executive site and a coupling mechanism, is followed by a general consideration of four binding criteria, which include hormone specificity, tissue specificity, high affinity and saturation, essential for distinguishing between specific and nonspecific binding. Experimental approaches are proposed for choosing an experimental system (either organized or soluble) and detecting the presence of protein binding sites. Techniques are then presented for evaluating the specific protein binding sites (receptors) in terms of the four criteria. This is followed by a brief consideration of how receptors may be located in cells and characterized when extracted. Finally various examples of oestrogen, androgen, progestagen, glucocorticoid and mineralocorticoid binding to their respective target tissues are presented, to illustrate how researchers have identified specific corticoid and mineralocorticoid binding in their respective target tissue receptors.

Anionic and Cationic Redox Processes in β-Li2IrO3 and Their Structural Implications on Electrochemical Cycling in Li-Ion Cell

2019 ◽  
Author(s):  
Paul Pearce ◽  
Gaurav Assat ◽  
Antonella Iadecola ◽  
François Fauth ◽  
Rémi Dedryvère ◽  
...  
Keyword(s):  
Analytical Techniques ◽  
Charge Compensation ◽  
Coupling Mechanism ◽  
Redox Processes ◽  
Positive Electrodes ◽  
X Ray ◽  
Electrochemical Cycling ◽  
Li Ion ◽  
Electrochemical Instability ◽  
High Degree

The recent discovery of anionic redox as a means to increase the energy density of transition metal oxide positive electrodes is now a well established approach in the Li-ion battery field. However, the science behind this new phenomenon pertaining to various Li-rich materials is still debated. Thus, it is of paramount importance to develop a robust set of analytical techniques to address this issue. Herein, we use a suite of synchrotron-based X-ray spectroscopies as well as diffraction techniques to thoroughly characterize the different redox processes taking place in a model Li-rich compound, the tridimentional hyperhoneycomb β-Li2IrO3. We clearly establish that the reversible removal of Li+ from this compound is associated to a previously described reductive coupling mechanism and the formation of the M-(O-O) and M-(O-O)* states. We further show that the respective contributions to these states determine the spectroscopic response for both Ir L3-edge X-ray absorption spectroscopy (XAS) and X-ray photoemissions spectroscopy (XPS). Although the high covalency and the robust tridimentional structure of this compound enable a high degree of reversibile delithiation, we found that pushing the limits of this charge compensation mechanism has significant effects on the local as well as average structure, leading to electrochemical instability over cycling and voltage decay. Overall, this work highlights the practical limits to which anionic redox can be exploited and sheds some light on the nature of the oxidized species formed in certain lithium-rich compounds.<br>

Anionic and Cationic Redox Processes in β-Li2IrO3 and Their Structural Implications on Electrochemical Cycling in Li-Ion Cell

2019 ◽  
Author(s):  
Paul Pearce ◽  
Gaurav Assat ◽  
Antonella Iadecola ◽  
François Fauth ◽  
Rémi Dedryvère ◽  
...  
Keyword(s):  
Analytical Techniques ◽  
Charge Compensation ◽  
Coupling Mechanism ◽  
Redox Processes ◽  
Positive Electrodes ◽  
X Ray ◽  
Electrochemical Cycling ◽  
Li Ion ◽  
Electrochemical Instability ◽  
High Degree

The recent discovery of anionic redox as a means to increase the energy density of transition metal oxide positive electrodes is now a well established approach in the Li-ion battery field. However, the science behind this new phenomenon pertaining to various Li-rich materials is still debated. Thus, it is of paramount importance to develop a robust set of analytical techniques to address this issue. Herein, we use a suite of synchrotron-based X-ray spectroscopies as well as diffraction techniques to thoroughly characterize the different redox processes taking place in a model Li-rich compound, the tridimentional hyperhoneycomb β-Li2IrO3. We clearly establish that the reversible removal of Li+ from this compound is associated to a previously described reductive coupling mechanism and the formation of the M-(O-O) and M-(O-O)* states. We further show that the respective contributions to these states determine the spectroscopic response for both Ir L3-edge X-ray absorption spectroscopy (XAS) and X-ray photoemissions spectroscopy (XPS). Although the high covalency and the robust tridimentional structure of this compound enable a high degree of reversibile delithiation, we found that pushing the limits of this charge compensation mechanism has significant effects on the local as well as average structure, leading to electrochemical instability over cycling and voltage decay. Overall, this work highlights the practical limits to which anionic redox can be exploited and sheds some light on the nature of the oxidized species formed in certain lithium-rich compounds.<br>

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