scholarly journals Level and Value of Circulating Endothelial Progenitor Cells in Patients After Acute Ischemic Stroke

Stroke ◽  
2008 ◽  
Vol 39 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Hon-Kan Yip ◽  
Li-Teh Chang ◽  
Wen-Neng Chang ◽  
Cheng-Hsien Lu ◽  
Chia-Wei Liou ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor ◽  
Circulating Endothelial Progenitor Cells

CDP-choline treatment increases circulating endothelial progenitor cells in acute ischemic stroke

2011 ◽  
Vol 33 (6) ◽  
pp. 572-577 ◽  
Author(s):  
Tomás Sobrino ◽  
Raquel Rodríguez-González ◽  
Miguel Blanco ◽  
David Brea ◽  
María Pérez-Mato ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor ◽  
Circulating Endothelial Progenitor Cells

scholarly journals The Increase of Circulating Endothelial Progenitor Cells After Acute Ischemic Stroke Is Associated With Good Outcome

Stroke ◽  
2007 ◽  
Vol 38 (10) ◽  
pp. 2759-2764 ◽  
Author(s):  
Tomás Sobrino ◽  
Olivia Hurtado ◽  
María Ángeles Moro ◽  
Manuel Rodríguez-Yáñez ◽  
Mar Castellanos ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor ◽  
Good Outcome ◽  
Circulating Endothelial Progenitor Cells

Abstract 1941: Level and Value of Circulating Endothelial Progenitor Cells in Patients after Acute Ischemic Stroke

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Yip Hon-Kan
Keyword(s):  
At Risk ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Neurological Impairment ◽  
Systemic Circulation ◽  
Endothelial Progenitor ◽  
Tissue Ischemia ◽  
Severe Neurological Impairment

Background and Purpose Endothelial progenitor cells (EPCs) migrate from bone marrow to systemic circulation in response to tissue ischemia where they differentiate into mature endothelial cells for in situ angiogenesis. This study tested the hypothesis that the level of circulating EPCs is substantially increased and predictive of prognostic outcomes after acute ischemic stroke. Methods The level of circulating EPCs [staining markers: CD31/CD34 (E 1 ), CD62E/CD34 (E 2 ) and KDR/CD34 (E 3 )] was examined using flow cytometry at 48 h after acute ischemic stroke in 138 consecutive patients. The EPC level was also evaluated once in twenty healthy volunteers and in forty at-risk controls. Results Level of circulating EPCs (E 1–3 ) was significantly higher in ischemic stroke patients than in at-risk control subjects ( p <0.05). Additionally, EPC (E 1–3 ) level was significantly lower in patients with severe neurological impairment [defined as a score ≥12 on the National Institute of Health Stroke Scale (NIHSS)] than in patients with less severe impairment (NIHSS < score 12) at 48 h after ischemic stroke ( p <0.0001). Moreover, the EPC (E 3 ) level was strongly correlated with improved NIHSS ≥ 4 on day 21 after ischemic stroke ( p =0.0004). Furthermore, low circulating EPC level was independently predictive of severe neurological impairment (NIHSS ≥ 12) at 48 h (E 1–3 ) and combined major adverse clinical outcomes (defined as recurrent ischemic stroke, any cause of death, or NIHSS of ≥ 12) on day 90 (E 1 ) following ischemic stroke ( p <0.001). Conclusions Level of circulating EPCs is independently predictive of prognosis after ischemic stroke.

scholarly journals The angiogenic gene profile of circulating endothelial progenitor cells from ischemic stroke patients

Vascular Cell ◽  
2013 ◽  
Vol 5 (1) ◽  
pp. 3 ◽  
Author(s):  
Míriam Navarro-Sobrino ◽  
Mar Hernández-Guillamon ◽  
Israel Fernandez-Cadenas ◽  
Marc Ribó ◽  
Ignacio A Romero ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Gene Profile ◽  
Stroke Patients ◽  
Endothelial Progenitor ◽  
Circulating Endothelial Progenitor Cells ◽  
Angiogenic Gene
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