Abstract TP205: Cerebrovascular Diseases in Hispanic Patients With Systemic Lupus Erythematosus

Stroke ◽  
2018 ◽  
Vol 49 (Suppl_1) ◽  
Author(s):  
Carlos Cantú-Brito ◽  
Paola Guraieb-Chaín ◽  
Sergio I Valdés-Ferrer ◽  
Adriãn Soto-Mota ◽  
Lorena Guerrero-Torres ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Cerebrovascular Diseases ◽  
Systemic Lupus ◽  
Hispanic Patients

Anti-CD20 therapy in patients with refractory systemic lupus erythematosus: a longitudinal analysis of 52 Hispanic patients

Lupus ◽  
2009 ◽  
Vol 19 (2) ◽  
pp. 213-219 ◽  
Author(s):  
M. Garcia-Carrasco ◽  
C. Mendoza-Pinto ◽  
M. Sandoval-Cruz ◽  
E. Soto-Vega ◽  
A. Beltran-Castillo ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Longitudinal Analysis ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Hispanic Patients ◽  
Anti Cd20

Thyroid nodules in Hispanic patients with systemic lupus erythematosus

Lupus ◽  
2013 ◽  
Vol 22 (14) ◽  
pp. 1509-1513 ◽  
Author(s):  
DL Quintanilla-Flores ◽  
MI Hernández-Coria ◽  
G Elizondo-Riojas ◽  
DA Galarza-Delgado ◽  
JG González-González ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Thyroid Nodules ◽  
Systemic Lupus ◽  
Hispanic Patients

Stroke in systemic lupus erythematosus: epidemiology, mechanism, and long-term outcome

Lupus ◽  
2020 ◽  
Vol 29 (5) ◽  
pp. 437-445
Author(s):  
P Guraieb-Chahín ◽  
C Cantú-Brito ◽  
A Soto-Mota ◽  
L Guerrero-Torres ◽  
F Flores-Silva ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Stroke Recurrence ◽  
Systemic Lupus ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Hispanic Patients ◽  
Ischemic Attack ◽  
Demographical Data

Objective To determine stroke prevalence, mechanisms, and long-term outcome in a cohort of Hispanic patients with systemic lupus erythematosus (SLE). Methods We analyzed demographical data, the timing between SLE diagnosis and stroke onset, stroke type, recurrence, and outcomes from an institutional database of 4451 patients with SLE followed from 1993 to 2018. Results We observed 139 strokes (3.1%), for an incidence rate of 1.25 per 1000 person-years: 81 (58.3%) acute ischemic stroke (AIS), 19 (13.7%) subarachnoid hemorrhage (SAH), 17 (12.2%) cerebral venous thrombosis, 13 (9.4%) intracerebral hemorrhage (ICH), and 9 (6.5%) transient ischemic attack. Median time from SLE diagnosis to acute stroke was 60 months (interquartile range 12–132 months). AIS had a bimodal presentation with 26% occurring within the first year and 30% >10 years after SLE diagnosis. In contrast, 75% of ICH cases occurred >3 years (and 34% >10 years) after SLE diagnosis. The most important cause of AIS was secondary antiphospholipid syndrome (48%). Hypertension was associated with 69% of ICH cases, while aneurysmal rupture was observed in 78% of SAH cases. Excellent recovery at hospital discharge was observed in 65%. Stroke recurrence was observed in 7%. The long-term all-cause fatality rate was 8%. Conclusions The prevalence of stroke in this cohort was 3.1%. Ischemic strokes had a bimodal presentation, occurring either early after SLE diagnosis or after a several-year delay. Half of the hemorrhagic strokes occurred >10 years after the diagnosis of SLE. Clinical outcome was usually good with a relatively low recurrence rate.

Organized Intraglomerular Deposits in NZB Mouse Disease

1971 ◽  
Vol 29 ◽  
pp. 544-545
Author(s):  
Francis R. Comerford ◽  
Alan S. Cohen
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antinuclear Antibodies ◽  
Human Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
Glomerular Lesion ◽  
Ultrastructural Studies ◽  
Dense Deposits ◽  
Experimental Nephritis ◽  
Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

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