scholarly journals Sudden Cardiac Death Substrate Imaged by Magnetic Resonance Imaging

2017 ◽  
Vol 10 (7) ◽  
Author(s):  
Katherine C. Wu
Keyword(s):  
Magnetic Resonance Imaging ◽  
Sudden Cardiac Death ◽  
Magnetic Resonance ◽  
Cardiac Death ◽  
Resonance Imaging

scholarly journals Myocardial Inflammation, Sports Practice, and Sudden Cardiac Death: 2021 Update

Medicina ◽  
2021 ◽  
Vol 57 (3) ◽  
pp. 277
Author(s):  
Paolo Compagnucci ◽  
Giovanni Volpato ◽  
Umberto Falanga ◽  
Laura Cipolletta ◽  
Manuel Antonio Conti ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cardiac Magnetic Resonance ◽  
Sudden Cardiac Death ◽  
Magnetic Resonance ◽  
Cardiac Death ◽  
Current Knowledge ◽  
Myocardial Inflammation ◽  
Resonance Imaging ◽  
Inflammatory Cardiomyopathy ◽  
The Relationship

Myocardial inflammation is an important cause of cardiovascular morbidity and sudden cardiac death in athletes. The relationship between sports practice and myocardial inflammation is complex, and recent data from studies concerning cardiac magnetic resonance imaging and endomyocardial biopsy have substantially added to our understanding of the challenges encountered in the comprehensive care of athletes with myocarditis or inflammatory cardiomyopathy (ICM). In this review, we provide an overview of the current knowledge on the epidemiology, pathophysiology, diagnosis, and treatment of myocarditis, ICM, and myopericarditis/perimyocarditis in athletes, with a special emphasis on arrhythmias, patient-tailored therapies, and sports eligibility issues.

scholarly journals ADDITIONAL VALUE OF QUANTIFICATION OF MYOCARDIAL FIBROSIS BY CONTRAST-ENHANCED MRI TO IDENTIFY SUBJECTS WITH HYPERTROPHIC CARDIOMYOPATHY AND SUDDEN CARDIAC DEATH RISK

2019 ◽  
Vol 34 (1) ◽  
pp. 33-38
Author(s):  
S. M. Komissarova ◽  
E. Yu. Zakharova ◽  
T. V. Ilyina ◽  
E. A. Vankovich
Keyword(s):  
Magnetic Resonance Imaging ◽  
Hypertrophic Cardiomyopathy ◽  
Sudden Cardiac Death ◽  
Magnetic Resonance ◽  
Myocardial Fibrosis ◽  
Cardiac Death ◽  
Low Risk ◽  
Resonance Imaging ◽  
Death Risk ◽  
Sudden Cardiac Death Risk

Background. A 5-year sudden cardiac death risk model in line with ESC-2014 (HCM Risk-SCD score) Guidelines assesses the risk of sudden cardiac death in individuals with hypertrophic cardiomyopathy using clinical parameters without taking into account magnetic resonance imaging indices including myocardial fibrosis.Aim. To compare subjects with low, moderate, and high sudden cardiac death risks, identified based on HCM Risk-SCD score, with delayed enhancement magnetic resonance imaging-evidenced fibrosis and to assess the role of fibrosis in identification of patients with sudden cardiac death risk.Material and Methods. A total of 98 patients with hypertrophic cardiomyopathy underwent an integrative examination including cardiac echocardiography, 24-h electrocardiography monitoring, delayed gadolinium-enhanced magnetic resonance imaging, and an assessment of a 5-year sudden cardiac death risk by HCM Risk-SCD score.Results and Discussion. Out of 98 patients, 45 (46%) patients had low risk of sudden cardiac death, 26 (26%) patients had intermediate risk, and 27 (28%) patients had high sudden cardiac death risk by HCM Risk-SCD score. During the follow-up period, (mean 41 months; 25 to 58 months), 16 adverse events were registered: sudden cardiac death occurred in 9 patients while 7 patients had been successfully resuscitated and implanted with implantable cardioverter defibrillator for secondary prevention of sudden cardiac death. The risk assessment using HCM Risk-SCD score showed high risk in 8 out of 16 (50%) patients; 2 (12.5%) patients had moderate risk, while 6 (37.5%) patients had low risk. High-risk patients demonstrated significantly (p<0.001) larger fibrosis (mean 28.5%; quartiles 21.9%; 44.1%) compared to those with moderate risk (mean 17.6%; quartiles 8.0%; 22.5%) and low risk of sudden cardiac death (mean 11.7%; quartiles 5.8%; 17.6%). The volume of fibrosis by delayed contrast-enhanced magnetic resonance imaging was associated with the adverse outcomes rate, which was 15%. A Log rank test in the KaplanMeier survival analysis showed statistically significant differences (p=0,002) in groups with fibrosis <15% and≥15%. The regression analysis showed that myocardial fibrosis was more significant factor associated with sudden cardiac death (OR 12; 95% CI 1.6–91) compared to SCD ESC-2014 score (OR 2.8 95% CI 1.1–7.5).Conclusion. Therefore, based on regression analysis, patients with hypertrophic cardiomyopathy who had myocardial fibrosis volume ≥15% were identified as a group with risk of sudden cardiac death and adverse arrhythmic events.

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