scholarly journals Prevalence and Clinical Profile of Myocardial Crypts in Hypertrophic Cardiomyopathy

2012 ◽  
Vol 5 (4) ◽  
pp. 441-447 ◽  
Author(s):  
Martin S. Maron ◽  
Ethan J. Rowin ◽  
David Lin ◽  
Evan Appelbaum ◽  
Raymond H. Chan ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Clinical Profile ◽  
Myocardial Crypts

scholarly journals Response to Letter Regarding Article, “Prevalence and Clinical Profile of Myocardial Crypts in Hypertrophic Cardiomyopathy”

2012 ◽  
Vol 5 (5) ◽  
Author(s):  
Martin S. Maron ◽  
Ethan J. Rowin ◽  
David Lin ◽  
Evan Appelbaum ◽  
C. Michael Gibson ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Clinical Profile ◽  
Myocardial Crypts

scholarly journals PREVALENCE AND CLINICAL PROFILE OF MYOCARDIAL CRYPTS IN HYPERTROPHIC CARDIOMYOPATHY

2011 ◽  
Vol 57 (14) ◽  
pp. E191 ◽  
Author(s):  
Martin S. Maron ◽  
Ethan Rowin ◽  
David Lin ◽  
Evan Appelbaum ◽  
C. Michael Gibson ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Clinical Profile ◽  
Myocardial Crypts

scholarly journals Clinical profile of stroke in 900 patients with hypertrophic cardiomyopathy

2002 ◽  
Vol 39 (2) ◽  
pp. 301-307 ◽  
Author(s):  
Barry J Maron ◽  
Iacopo Olivotto ◽  
Pietro Bellone ◽  
Maria Rosa Conte ◽  
Franco Cecchi ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Clinical Profile

P894The association of the polymorphic variant rs1739843 of the hspb7 gene with clinical profile and outcomes in patients with hypertrophic cardiomyopathy (10 years follow-up)

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
A Streltsova ◽  
A Gudkova ◽  
A Poliakova ◽  
S Pyko ◽  
A Kostareva
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Allele Frequency ◽  
Functional Class ◽  
Clinical Profile ◽  
Genotype Frequency ◽  
Polymorphic Variant ◽  
Control Group ◽  
Healthy Donors ◽  
The Impact ◽  
Benign Course

Abstract Purpose The aim of this study was to determine the impact of polymorphic variant rs1739843 of the hspb7 gene on clinical profile and outcomes in patients with hypertrophic cardiomyopathy (HCM). Methods The study population consisted of 108 patients with HCM ≥45 years old. The control group included 192 healthy donors. A novel disease pathway model, firstly designed in foreign outcome study (2017), was employed to assess clinical course of HCM. SNP rs1739843 of the hspb7 gene was genotyped by allele-specific real-time polymerase chain reaction (PCR) assay. Results It was found a significant increase in TT genotype frequency of rs1739843 of the hspb7 gene in patients with HCM (n=108) – 20.4%, compared with control group (n=192) – 4.2% (TT: TC+CC, odds ratio (OR) = 5.88, 95% confidence interval (CI) = 2.52–13.75, p<0.001). High prevalence of CC genotype of rs1739843 of the hspb7 gene was observed in control group – 80.2% vs 31.5% in HCM (CC: TC+TT, OR = 0.11, 95% CI = 0.07–0.19, p<0.001). The allele frequency (C: T) also differed between HCM and control groups – 55.6: 44.4% in HCM, vs 88.02: 11.98% in control group (OR = 5.88, 95% CI = 3.91–8.85, p<0.001). It was also found a significant increase in TT genotype frequency of rs1739843 of the hspb7 gene in HCM patients with benign course free of adverse pathways (n=48) – 16.7%, compared with control group (n=192) – 4.2% (TT: TC+CC, OR= 4.60, 95% CI = 1.63–12.99, p<0.001)). The allele frequency (C: T) in HCM patients with benign course free of adverse pathways was 56.3: 43.7% vs 88.02: 11.98% in control group (OR = 5.71, 95% CI= 3.44–9.49, p<0.001). The mortality rate of HCM patients with 1, 2 or 3 adverse pathways was higher compared with HCM patients with benign course free of adverse pathways. HCM patients ≥45 years old showed a significant increase in T allele frequency in cases of presence of 2 (CHF (chronic heart failure) III–IV functional class (NYHA) + AF (atrial fibrillation)) and 3 adverse pathways (CHF III-IV functional class (NYHA) + AF + SCD (sudden cardiac death) of HCM progression. Conclusions The T allele and TT genotype of rs1739843 of the hspb7 gene were more frequent in patients with HCM ≥45 years old, compared with control group. It was also found a significant increase in frequency of TT genotype and T allele of rs1739843 of the hspb7 gene in HCM patients with benign course free of adverse pathways, compared with control group. HCM progression along 2 and more adverse pathways in patients ≥45 years old has been characterized with adverse outcome. Allele T of rs1739843 of the hspb7 gene was associated with 2 and more adverse pathways of HCM progression.

PREVALENCE, CLINICAL PROFILE, AND OUTCOME OF CARDIORENAL SYNDROME IN SYMPTOMATIC PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY

2019 ◽  
Vol 73 (9) ◽  
pp. 761
Author(s):  
Mikhail Romashko ◽  
Martin Maron ◽  
Barry Maron ◽  
James Udelson ◽  
Jeffrey M. Testani ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Cardiorenal Syndrome ◽  
Clinical Profile

scholarly journals An Unusual Presentation of a Myocardial Crypt in Hypertrophic Cardiomyopathy

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
Danny A. J. P. van de Sande ◽  
Jan Hoogsteen ◽  
Luc J. H. J. Theunissen
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Interventricular Septum ◽  
Positive Family History ◽  
Phenotypic Expression ◽  
Anterior Wall ◽  
Left Ventricular ◽  
Genes Encoding ◽  
History Of ◽  
Basal Septum ◽  
Myocardial Crypts

Hypertrophic cardiomyopathy (HCM) is a common inherited cardiovascular disease with prevalence of 0.2% in the population. More than 1000 mutations in more than 10 genes encoding for proteins of the cardiac sarcomere have been identified. Cardiac magnetic resonance imaging (CMR) is used to characterize left ventricular morphology with great precision in patients with HCM and it identifies unique structural abnormalities in patients with HCM. We present a case of a 56-year-old man who had positive family history of HCM who was a carrier of the genetic MYH-7 2770 G > C, exon 23 mutation. Transthoracic echocardiography showed thickening of the interventricular septum (16 mm) and in particular the basal septum. CMR confirmed the diagnosis of HCM in the anteroseptal myocardium with a thickness of 23 mm and also revealed large and deep myocardial crypts in the anterior wall. These myocardial crypts are rarely found in the so-called genotype positive and phenotype positive patients, as in our case. Also the crypts in this case are deeper and wider than those reported in other cases. So in conclusion, this case reveals an uncommon finding of a myocardial crypt at an unusual myocardial site with the unusual morphology in a patient with genotypic and phenotypic expression of hypertrophic cardiomyopathy.

scholarly journals Prevalence, Clinical Profile, and Significance of Left Ventricular Remodeling in the End-Stage Phase of Hypertrophic Cardiomyopathy

Circulation ◽  
2006 ◽  
Vol 114 (3) ◽  
pp. 216-225 ◽  
Author(s):  
Kevin M. Harris ◽  
Paolo Spirito ◽  
Martin S. Maron ◽  
Andrey G. Zenovich ◽  
Francesco Formisano ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Clinical Profile ◽  
End Stage
Sign in / Sign up

Export Citation Format

Share Document