scholarly journals Experimental cerebral infarction. Part 3: Protective effect of mannitol in thalamic infarction in dogs.

Stroke ◽  
1978 ◽  
Vol 9 (3) ◽  
pp. 217-218 ◽  
Author(s):  
T Yoshimoto ◽  
T Sakamoto ◽  
T Watanabe ◽  
S Tanaka ◽  
J Suzuki
Keyword(s):  
Cerebral Infarction ◽  
Protective Effect ◽  
Thalamic Infarction ◽  
Experimental Cerebral Infarction

scholarly journals Experimental cerebral infarction. Part 2: Electroencephalographic changes produced by experimental thalamic infarction in dogs.

Stroke ◽  
1978 ◽  
Vol 9 (3) ◽  
pp. 214-216 ◽  
Author(s):  
T Sakamoto ◽  
S Tanaka ◽  
T Yoshimoto ◽  
T Watanabe ◽  
J Suzuki
Keyword(s):  
Cerebral Infarction ◽  
Thalamic Infarction ◽  
Experimental Cerebral Infarction

scholarly journals In vivo 31P NMR studies on experimental cerebral infarction.

1983 ◽  
Vol 33 (1) ◽  
pp. 19-28 ◽  
Author(s):  
Shoji NARUSE ◽  
Soshun TAKADA ◽  
Izumi KOIZUKA ◽  
Hiroshi WATARI
Keyword(s):  
Cerebral Infarction ◽  
31P Nmr ◽  
Nmr Studies ◽  
Experimental Cerebral Infarction

Effect of Parecoxib on Hippocampus and Hypothalamic Orexin Neurons in Rats with Cerebral Infarction

2021 ◽  
Vol 11 (4) ◽  
pp. 679-683
Author(s):  
Yapeng Guo ◽  
Heng Xu ◽  
Xuyi Li ◽  
Zhiming Zhou
Keyword(s):  
Cerebral Infarction ◽  
Protective Effect ◽  
Infarct Size ◽  
Hippocampal Neurons ◽  
Neuronal Apoptosis ◽  
Low Dose ◽  
Human Life ◽  
Sham Operation ◽  
Sham Operation Group ◽  
Orexin Neuron

Cerebral infarction has seriously threatened human life and health. Parecoxib is the first nonsteroidal analgesic for surgical analgesia. However, its effect on orexin neurons during cerebral infarction treatment is unclear. In this study, a rat model of cerebral infarction was established by suture method. The experiment was assigned into sham operation group, cerebral infarction model group (MCAO), high and low dose group of parecoxib. Western blotting and immunofluorescence staining was used to evaluate the activity of orexin neurons. The infarct size was evaluated by TTC staining. The apoptosis of neurons in hypothalamus and hippocampus was determined by AV-PI staining. TTC staining suggested that parecoxib treatment significantly reduced cerebral infarct size, increased orexin neuronal activity, and decreased neuronal apoptosis in hypothalamus and hippocampus, which were significantly different from sham-operated groups. This study demonstrates that parecoxib has a protective effect on cerebral infarction rats, which can inhibit the apoptosis of hypothalamic and hippocampal neurons through the orexin neuron pathway. It provides a theoretical basis for the protective effect of parecoxib, indicating that it might be a new target for the treatment of cerebral infarction.

scholarly journals Interventional procedure for experimental cerebral infarction model in rats. : Assessment of materials for embolization.

1991 ◽  
Vol 55 ◽  
pp. 141
Author(s):  
Shino Usami ◽  
Yuko Kanda ◽  
Masahiro Inagaki ◽  
Junkichi Izumi ◽  
Manabu Matsumoto ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Interventional Procedure ◽  
Experimental Cerebral Infarction

scholarly journals Assessment of embolization materials for experimental cerebral infarction model in rats

1992 ◽  
Vol 58 ◽  
pp. 252
Author(s):  
Shino Usami ◽  
Yuko Kanda ◽  
Masahiro Inagaki ◽  
Daichi Morioka ◽  
Yuji Kiuchil ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Experimental Cerebral Infarction
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