scholarly journals Measurement of regional brain glucose utilization in vivo using [2(-14)C] glucose.

Stroke ◽  
1979 ◽  
Vol 10 (6) ◽  
pp. 690-703 ◽  
Author(s):  
R Hawkins ◽  
W K Hass ◽  
J Ransohoff
Keyword(s):  
Glucose Utilization ◽  
Brain Glucose ◽  
Regional Brain ◽  
Brain Glucose Utilization

scholarly journals Regional Blood—Brain Glucose Transfer and Glucose Utilization in Chronically Hyperglycemic, Diabetic Rats following Acute Glycemic Normalization

1990 ◽  
Vol 10 (6) ◽  
pp. 774-780 ◽  
Author(s):  
D. A. Pelligrino ◽  
M. D. Lipa ◽  
R. F. Albrecht
Keyword(s):  
Plasma Glucose ◽  
Glucose Utilization ◽  
Diabetic Rats ◽  
Normal Range ◽  
Brain Glucose ◽  
Glucose Transfer ◽  
Regional Brain ◽  
Blood Brain ◽  
Control Plasma ◽  
Brain Glucose Utilization

Regional rates of brain glucose utilization (rCMRglc) and glucose influx (rJin), along with regional brain tissue glucose concentrations, were measured in chronically hyperglycemic diabetic (CHD) rats following acute glycemic normalization. These results were compared to those obtained in nondiabetic normoglycemic controls. The diabetic rats were evaluated at 6–8 weeks following i.p. streptozotocin injection. All rats were N2O (70%) sedated, paralyzed, and artificially ventilated for study. Acutely normoglycemic (plasma glucose = 7.9 µmol/ml) CHD rats, compared to control (plasma glucose = 8.5 µmol/ml), demonstrated significantly higher ( p < 0.05) rCMRglc and rJin values in 8 of the 11 regions analyzed. Tissue/plasma glucose concentration ratios were significantly greater than control in 9 of 11 regions. Prior to acute glycemic normalization, rCMRglc values in CHD rats were either unchanged or moderately lower than control. These findings indicate that no blood–brain barrier glucose transport repression is present in CHD rats. In fact, the results suggest an increased transport capacity. The increased rCMRglc observed in the acutely normalized CHD rats may be a manifestation of the “hypoglycemic symptoms” observed in chronically hyperglycemic patients following acute glycemic reductions to the normal range. The present results imply that these symptoms are not related to the presence of a relative cerebral glucopenia, as others have suggested.

Regional brain glucose utilization during and following chronic naltrexone administration: Preliminary observations in rat brain

Life Sciences ◽  
1989 ◽  
Vol 44 (8) ◽  
pp. 571-577 ◽  
Author(s):  
Diana L. Dow-Edwards ◽  
Thomas H. Milhorat ◽  
Laurel A. Freed ◽  
Alan R. Gintzler
Keyword(s):  
Rat Brain ◽  
Glucose Utilization ◽  
Brain Glucose ◽  
Regional Brain ◽  
Brain Glucose Utilization

Effect of food deprivation on regional brain glucose utilization in lean and fatty Zucker rats

1988 ◽  
Vol 475 (2) ◽  
pp. 371-375 ◽  
Author(s):  
Satoru Tsujii ◽  
Yoshikatsu Nakai ◽  
Hideo Takahashi ◽  
Takeshi Usui ◽  
Toshikiyo Koh ◽  
...  
Keyword(s):  
Food Deprivation ◽  
Glucose Utilization ◽  
Zucker Rats ◽  
Brain Glucose ◽  
Regional Brain ◽  
Effect Of Food ◽  
Brain Glucose Utilization
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