scholarly journals Cyclic guanosine monophosphate mediates vascular relaxation induced by atrial natriuretic factor.

Hypertension ◽  
1985 ◽  
Vol 7 (2) ◽  
pp. 306-310 ◽  
Author(s):  
E H Ohlstein ◽  
B A Berkowitz
Keyword(s):  
Atrial Natriuretic Factor ◽  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Vascular Relaxation ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

Left Atrial Function and Atrial Natriuretic Factor/Cyclic Guanosine Monophosphate Changes in DDD and VVI Pacing Modes

1997 ◽  
Vol 79 (3) ◽  
pp. 366-370 ◽  
Author(s):  
George N Theodorakis ◽  
Fotis Panou ◽  
Manolis Markianos ◽  
Nikolaos Fragakis ◽  
Efthimios G Livanis ◽  
...  
Keyword(s):  
Atrial Natriuretic Factor ◽  
Left Atrial ◽  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Atrial Function ◽  
Left Atrial Function ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

Changed cyclic guanosine monophosphate atrial natriuretic factor relationship in hypertensive man

1989 ◽  
Vol 7 (4) ◽  
pp. 287???292 ◽  
Author(s):  
Niels Eske Bruun ◽  
Meta Damkjaer Nielsen ◽  
Peter Skostt ◽  
JoSrn Giese ◽  
Arne Leth ◽  
...  
Keyword(s):  
Atrial Natriuretic Factor ◽  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

Pathophysiology of congestive heart failure: role of atrial natriuretic factor and therapeutic implications

1991 ◽  
Vol 69 (10) ◽  
pp. 1576-1581 ◽  
Author(s):  
Mark A. Perrella ◽  
Kenneth B. Margulies ◽  
John C. Burnett Jr.
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Atrial Natriuretic Factor ◽  
Neutral Endopeptidase ◽  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

Endogenous atrial natriuretic factor (ANF) serves a functional role to maintain sodium homeostasis and inhibit activation of the renin–angiotensin–aldosterone system in acute congestive heart failure despite arterial hypotension. However, as heart failure progresses, maximal synthesis and release of ANF from both the atrial and ventricular myocardium may occur resulting in relative ANF deficiency. This relative deficiency of ANF results in a progressive inability to excrete sodium and antagonize the renin–angiotensin–aldosterone system. Consequently, agents that increase circulating ANF and (or) enhance its local action have potential therapeutic efficacy. Recent studies suggest that inhibitors of neutral endopeptidase 24.11, which block ANF degradation, potentiate the natriuretic action of endogenous ANF independent of systemic or renal hemodynamics. This action does not parallel increases in plasma ANF and is associated with marked increases in urinary ANF and cyclic guanosine monophosphate consistent with enhanced local action of the peptide. In addition, agents that selectively bind to biologically inactive ANF clearance receptors increase endogenous plasma ANF and promote increases in renal sodium excretion. These studies suggest a therapeutic role for neutral endopeptidase inhibition and clearance receptor blockade, while advancing our understanding of the pathophysiology of ANF in congestive heart failure.Key words: congestive heart failure, atrial natriuretic factor, cyclic guanosine monophosphate, natriuresis, renin–angiotensin–aldosterone system.

Intracoronary and systemic release of the atrial natriuretic factor and cyclic-guanosine monophosphate during coronary angioplasty

1996 ◽  
Vol 3 (4) ◽  
pp. 221-226 ◽  
Author(s):  
Efstathios K. Iliodromitis ◽  
George K. Karavolias ◽  
Manolis Markianos ◽  
Zenon S. Kyriakides ◽  
Demetrios V. Vlahakos ◽  
...  
Keyword(s):  
Coronary Angioplasty ◽  
Atrial Natriuretic Factor ◽  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

Atrial natriuretic factor and cyclic guanosine monophosphate: Ion transport in rat colon in vitro and in vivo

1990 ◽  
Vol 99 (4) ◽  
pp. 1153-1156 ◽  
Author(s):  
Gwendolyn J. Barros ◽  
Nimish Vakil ◽  
Jolanta Gutkowska ◽  
Joseph Sellin ◽  
Gregory D. Potter
Keyword(s):  
Ion Transport ◽  
Atrial Natriuretic Factor ◽  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Rat Colon ◽  
Natriuretic Factor ◽  
Atrial Natriuretic
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