scholarly journals Influence of carboxyhemoglobin, gamma-glutamyl-transferase, body weight, and heart rate on blood pressure in middle-aged men.

Hypertension ◽  
1983 ◽  
Vol 5 (4) ◽  
pp. 560-563 ◽  
Author(s):  
N C Henningsen ◽  
L Janzon ◽  
E Trell
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Body Weight ◽  
Gamma Glutamyl Transferase ◽  
Middle Aged ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

Obstructive Sleep Apnea and Cardiovascular Risk Markers (Fibrinogen & Gamma Glutamyl Transferase) in Obese Males

2021 ◽  
Vol 15 (12) ◽  
pp. 3312-3314
Author(s):  
Shagufta Khaliq ◽  
Mudassar Ali Roomi ◽  
Shaheena Naz ◽  
Komal Iqbal ◽  
Muhammad Imran Ashraf ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Gamma Glutamyl Transferase ◽  
Strong Positive Correlation ◽  
Positive Correlation ◽  
Gamma Glutamyl ◽  
Obstructive Sleep ◽  
Glutamyl Transferase

Aim: To determine and compare gamma glutamyl transferase (GGT) and fibrinogen among obese males with and without obstructive sleep apnea (OSA). Second objective was to investigate correlation between blood pressure and GGT. Methodology: Sixty-four obese males aged 20-45 years with BMI > 25kg/m2 were included by convenience sampling. The study was conducted, after obtaining ethical approval from IRB, at the Department of Physiology, Post Graduate Medical Institute, Lahore from August 2014 to May 2015. Participants having acute or chronic inflammatory conditions were excluded. Participants were screened for OSA by Berlin and STOP BANG questionnaires. Diagnosis of OSA was made by overnight portable pulse oximetry. The participants were divided into two groups. Group I had 32 obese males with OSA. Group II contained 32 obese males without OSA. After an overnight fasting of 10-12 hours blood samples were drawn. Serum fibrinogen and GGT were measured by spectrophotometer. The data was analyzed using SPSS-22. Quantitative variables were compared between the two groups by Mann-Whitney U test. Spearman correlation was used to correlate blood pressure and GGT among the participants. Results: Fibrinogen was significantly raised (p=0.015) in obese males with OSA. Systolic blood pressure (p=0.003), diastolic blood pressure (p=0.001) and mean arterial blood pressure (p<0.001) showed strong positive correlation with GGT in obese males with OSA. Conclusion: Proinflammatory, procoagulant and proatherogenic marker fibrinogen levels were significantly raised in obese otherwise healthy males with OSA. Oxidative stress marker GGT showed strong positive correlation with blood pressure in obese males with OSA. Keywords: Fibrinogen, gamma glutamyl transferase, inflammation, obstructive sleep apnea, oxidative stress

scholarly journals Lead Exposure and Cardiovascular Disease among Young and Middle-Aged Adults

2019 ◽  
Vol 7 (11) ◽  
pp. 103 ◽  
Author(s):  
Emmanuel Obeng-Gyasi
Keyword(s):  
Blood Pressure ◽  
Logistic Regression ◽  
Lead Exposure ◽  
Binary Logistic Regression ◽  
The United States ◽  
Gamma Glutamyl Transferase ◽  
Middle Aged ◽  
The Mean ◽  
Glutamyl Transferase ◽  
Middle Aged Adults

Lead and its effects on cardiovascular-related markers were explored in this cross-sectional study of young adults (18–44 years) and middle-aged adults (45–65 years) from the United States using the National Health and Nutrition Examination Survey (NHANES), 2009–2016. Degrees of exposure were created using blood lead level (BLL) as the biomarker of exposure based on the epidemiologically relevant threshold of BLL > 5 μg/dL. The mean values, in addition to the percentages of people represented for the markers of interest (systolic blood pressure [SBP], diastolic blood pressure [DBP], gamma-glutamyl transferase [GGT], non-high-density lipoprotein cholesterol [non-HDL-C]) were explored. Among those exposed to lead, the likelihood of elevated clinical markers (as defined by clinically relevant thresholds of above normal) were examined using binary logistic regression. In exploring exposure at the 5 μg/dL levels, there were significant differences in all the mean variables of interest between young and middle-aged adults. The binary logistic regression showed young and middle-aged adults exposed to lead were significantly more likely to have elevated markers (apart from DBP). In all, lead affects cardiovascular-related markers in young and middle-aged U.S. adults and thus we must continue to monitor lead exposure to promote health.

scholarly journals Effects of change in body weight on serum aminotransferase and gamma-glutamyl transferase levels.

Sangyo Igaku ◽  
1993 ◽  
Vol 35 (1) ◽  
pp. 36-37
Author(s):  
Yutaka TAKASHIMA ◽  
Takashi AKAMATSU ◽  
Yasuhide ORIDO ◽  
Takaaki KINOUE
Keyword(s):  
Body Weight ◽  
Gamma Glutamyl Transferase ◽  
Serum Aminotransferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

scholarly journals Determination of Biochemical and Histological Parameters of Alcohol Administration in Wistar Rats

2019 ◽  
pp. 1-8
Author(s):  
O. G. Dawodu ◽  
O. A. T. Ebuehi ◽  
O. S. Odesanmi ◽  
M. O. Olalekan
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Water Intake ◽  
Wistar Rats ◽  
Ethanol Administration ◽  
Gamma Glutamyl Transferase ◽  
Alcohol Administration ◽  
Gamma Glutamyl ◽  
Alanine Amino Transferase ◽  
Glutamyl Transferase

Animal model development of alcohol administration in rats is of crucial importance as it gives indirect information to effects of alcohol in humans. An indirect assessment of this would be the biochemical and histological data that could arise from such experiments. 20 Male Wistar rats weighing (63.50±3.79 g), were divided into four groups (consisting 15 treated animals and 5 control animals) and administered with varying concentrations of ethanol (5% 15% and 40%) via intragastric intubation for a period of 28 days. Probic evaluations, liver biochemical enzymes and alteration in histology profile of gastrointestinal tract (GIT) and viscera organs (namely the liver, kidney, heart and lungs) were determined after experimental duration. At 40% ethanol administration, the rats showed biochemically significant decrease in serum gamma glutamyl transferase (GGT), serum aspartate (AST) and Alanine amino transferase (ALT) when compared to normal study while 5% and 15% ethanol administered rats were comparable with control values i.e. normal study. Probic evaluations such as body weight, water intake and food intake showed percentage decrease in 40% ethanol administrated rat when compared with controls. The photomicrographs of the 5% and 15% ethanol administered rats indicated mild damage in their histological profiles when compared to the normal study while there was more adverse damage occurring in the 40% ethanol administrated rats. Conclusion: From this study, serum aspartate (AST), gamma glutamyl transferase (GGT) and Alanine amino transferase (ALT), probic evaluation (body weight, food intake and water intake) coupled with histopathological investigation may be used as biomarker for the early diagnosis of ethanol toxicity in human beings.

scholarly journals Serum Gamma-Glutamyl Transferase Is Associated with Epicardial Fat Thickness in Middle Aged Women

2020 ◽  
Vol 71 (1) ◽  
pp. 430-435
Author(s):  
Adriana Albu ◽  
Anca Moldovan ◽  
Cristian Petra ◽  
Ioana Para
Keyword(s):  
Visceral Adiposity ◽  
Skewed Distribution ◽  
Epicardial Fat ◽  
Abdominal Circumference ◽  
Gamma Glutamyl Transferase ◽  
Middle Aged ◽  
Cross Sectional ◽  
Gamma Glutamyl ◽  
Cardiovascular Morbidity And Mortality ◽  
Glutamyl Transferase

Accumulating data indicate that gamma-glutamyl transferase (GGT) is associated with cardiovascular morbidity and mortality. A positive correlation between GGT levels and various cardiometabolic risk factors has been previously found. The aim of this study was to investigate the relationship between GGT and epicardial fat tissue thickness (EFTT) a marker of visceral adiposity. A total of one hundred five middle-aged (40-60 years) women were included in this cross-sectional study. EFTT was measured using 2-dimensional echocardiography, on the free wall of the right ventricle perpendicularly to the aortic annulus. Biochemical parameters were determined with an automated biochemical analyzer. Values of GGT were logarithmically transformed (log-GGT) because of their skewed distribution. We found that log-GGT correlated with age, body mass index, abdominal circumference, EFTT, triglycerides, fasting plasma glucose and uric acid. In multivariate regression analysis, log-GGT levels were independently associated with EFTT (�=0.27, p=0.004), postmenopausal status (�=0.25, p=0.008) and triglycerides (�=0.23, p=0.01). In conclusion, in middle-aged women, GGT independently correlated with EFTT and may be a marker of visceral adiposity and increased cardiovascular risk.

scholarly journals Bioflavonoid Robinin from Astragalus falcatus Lam. Mildly Improves the Effect of Metothrexate in Rats with Adjuvant Arthritis

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1268
Author(s):  
Lia Tsiklauri ◽  
Karol Švík ◽  
Martin Chrastina ◽  
Silvester Poništ ◽  
František Dráfi ◽  
...  
Keyword(s):  
Body Weight ◽  
Plasma Levels ◽  
Adjuvant Arthritis ◽  
Experimental Arthritis ◽  
Gamma Glutamyl Transferase ◽  
The Novel ◽  
Gamma Glutamyl ◽  
Adjuvant Induced Arthritis ◽  
Aerial Parts ◽  
Glutamyl Transferase

Anti-inflammatory potential of orally administrated bioflavonoid-robinin, active sub-stance of original drug Flaroninum™ (FL), was investigated in the combination with methotrexate (MTX) and in monotherapy in rats suffering from adjuvant-induced arthritis (AA). Robinin (kaempferol-3-O-robinoside-7-O-rhamnoside) was isolated from the aerial parts of Astragalus falcatus Lam. The monotherapy with robinin was not efficient in alleviating symptoms of AA. The combination of MTX with robinin was similarly active as MTX alone in reducing the hind paw volume and change of body weight during the whole experiment. The combination, however, reduced plasma levels of Interleukin-17Aand activity of gamma-glutamyl transferase in joint more efficiently then MTX alone. Our results demonstrate that the novel combination of robinin and MTX mildly improved the reduction of inflammation in experimental arthritis.

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