Acute hypertension in a nonhuman primate: humoral and hemodynamic mechanisms.

R J Cody; R F Rodger; L H Hartley; J Burton; J A Herd

doi:10.1161/01.hyp.4.2.219

Acute hypertension in a nonhuman primate: humoral and hemodynamic mechanisms.

Hypertension ◽

10.1161/01.hyp.4.2.219 ◽

1982 ◽

Vol 4 (2) ◽

pp. 219-225 ◽

Cited By ~ 11

Author(s):

R J Cody ◽

R F Rodger ◽

L H Hartley ◽

J Burton ◽

J A Herd

Keyword(s):

Nonhuman Primate ◽

Acute Hypertension

Download Full-text

Electron Microscopic Detection and Characterization of Nonhuman Primate Enteric Viruses

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100054145 ◽

1982 ◽

Vol 40 ◽

pp. 306-307

Author(s):

G. C. Smith ◽

R. L. Heberling ◽

S. S. Kalter

Keyword(s):

Electron Microscopy ◽

Animal Model ◽

Nonhuman Primate ◽

Clinical Condition ◽

Intestinal Tract ◽

Enteric Viruses ◽

Electron Microscopic ◽

Microscopic Detection

A number of viral agents are recognized as and suspected of causing the clinical condition “gastroenteritis.” In our attempts to establish an animal model for studies of this entity, we have been examining the nonhuman primate to ascertain what viruses may be found in the intestinal tract of “normal” animals as well as animals with diarrhea. Several virus types including coronavirus, adenovirus, herpesvirus, and picornavirus (Table I) were detected in our colony; however, rotavirus, astrovirus, and calicivirus have not yet been observed. Fecal specimens were prepared for electron microscopy by procedures reported previously.

Download Full-text

Permeability of the microcirculation in area postrema of rat

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100103802 ◽

1988 ◽

Vol 46 ◽

pp. 348-349

Author(s):

Shams M. Ghoneim ◽

Frank M. Faraci ◽

Gary L. Baumbach

Keyword(s):

Brain Stem ◽

Area Postrema ◽

Upper Body ◽

Sprague Dawley ◽

Sodium Cacodylate ◽

Acute Hypertension ◽

Sprague Dawley Rats ◽

Ultrastructural Characteristics ◽

The Brain ◽

Adjacent Brain

The area postrema is a circumventricular organ in the brain stem and is one of the regions in the brain that lacks a fully functional blood-brain barrier. Recently, we found that disruption of the microcirculation during acute hypertension is greater in area postrema than in the adjacent brain stem. In contrast, hyperosmolar disruption of the microcirculation is greater in brain stem. The objective of this study was to compare ultrastructural characteristics of the microcirculation in area postrema and adjacent brain stem.We studied 5 Sprague-Dawley rats. Horseradish peroxidase was injected intravenously and allowed to circulate for 1, 5 or 15 minutes. Following perfusion of the upper body with 2.25% glutaraldehyde in 0.1 M sodium cacodylate, the brain stem was removed, embedded in agar, and chopped into 50-70 μm sections with a TC-Sorvall tissue chopper. Sections of brain stem were incubated for 1 hour in a solution of 3,3' diaminobenzidine tetrahydrochloride (0.05%) in 0.05M Tris buffer with 1% H2O2.

Download Full-text