scholarly journals Endothelin-1–Independent and Angiotensin II–Independent Induction of Adrenomedullin Gene Expression

Hypertension ◽  
2001 ◽  
Vol 37 (1) ◽  
pp. 84-90 ◽  
Author(s):  
Hannu Romppanen ◽  
Jutta Puhakka ◽  
Gábor Földes ◽  
István Szokodi ◽  
Olli Vuolteenaho ◽  
...  
Keyword(s):  
Gene Expression ◽  
Angiotensin Ii ◽  
Endothelin 1

scholarly journals Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Wendy Rosales ◽  
Juan Carulla ◽  
Jeison García ◽  
Diana Vargas ◽  
Fernando Lizcano
Keyword(s):  
Gene Expression ◽  
Angiotensin Ii ◽  
Transient Transfection ◽  
Cardiac Cells ◽  
Pcr Analysis ◽  
Histone Demethylases ◽  
Rat Cardiomyocytes ◽  
Endothelin 1 ◽  
Cardiac Gene

Epigenetic changes induced by histone demethylases play an important role in differentiation and pathological changes in cardiac cells. However, the role of the jumonji family of demethylases in the development of cardiac hypertrophy remains elusive. In this study, the presence of different histone demethylases in cardiac cells was evaluated after hypertrophy was induced with neurohormones. A cell line from rat cardiomyocytes was used as a biological model. The phenotypic profiles of the cells, as well as the expression of histone demethylases, were studied through immunofluorescence, transient transfection, western blot, and qRT-PCR analysis after inducing hypertrophy by angiotensin II and endothelin-1. An increase in fetal gene expression (ANP, BNP, andβ-MHC) was observed in cardiomyocytes after treatment with angiotensin II and endothelin-1. A significant increase in JMJD2A expression, but not in UTX or JMJD2C expression, was observed. When JMJD2A was overexpressed in cardiomyocytes through transient transfection, the effect of neurohormones on fetal cardiac gene expression was increased. We conclude that JMJD2A plays a principal role in the regulation of fetal cardiac genes, which increase in expression during the pathological hypertrophic process.

scholarly journals Involvement of reactive oxygen species in angiotensin II-induced endothelin-1 gene expression in rat cardiac fibroblasts

2003 ◽  
Vol 42 (10) ◽  
pp. 1845-1854 ◽  
Author(s):  
Tzu-Hurng Cheng ◽  
Pao-Yun Cheng ◽  
Neng-Lang Shih ◽  
Iuan-Bor Chen ◽  
Danny Ling Wang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Reactive Oxygen Species ◽  
Angiotensin Ii ◽  
Cardiac Fibroblasts ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Endothelin 1

17β-Estradiol Downregulates Angiotensin-II-Induced Endothelin-1 Gene Expression in Rat Aortic Smooth Muscle Cells

2004 ◽  
Vol 11 (1) ◽  
pp. 27-36 ◽  
Author(s):  
Hong-Jye Hong ◽  
Ju-Chi Liu ◽  
Paul Chan ◽  
Shu-Hui Juan ◽  
Shih-Hurng Loh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Endothelin 1
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