scholarly journals Troglitazone Reduces Reactive Oxygen Species Generation by Leukocytes and Lipid Peroxidation and Improves Flow-Mediated Vasodilatation in Obese Subjects

Hypertension ◽  
2000 ◽  
Vol 36 (3) ◽  
pp. 430-435 ◽  
Author(s):  
Rajesh Garg ◽  
Yuvraj Kumbkarni ◽  
Ahmad Aljada ◽  
Priya Mohanty ◽  
Husam Ghanim ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Lipid Peroxidation ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Obese Subjects

Effects of silicon on plant resistance to environmental stresses: review

2013 ◽  
Vol 27 (2) ◽  
pp. 225-232 ◽  
Author(s):  
T. Balakhnina ◽  
A. Borkowska
Keyword(s):  
Reactive Oxygen Species ◽  
Lipid Peroxidation ◽  
Plant Resistance ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Guaiacol Peroxidase ◽  
Oxygen Species ◽  
Abiotic Stressors ◽  
Activity Of Enzymes

Abstract The role of exogenous silicon in enhancing plant resistance to various abiotic stressors: salinity, drought, metal toxicities and ultraviolet radiation are presented. The data on possible involvement of silicon in reducing the reactive oxygen species generation, intensity of lipid peroxidation, and in some cases, increasing the activity of enzymes of the reactive oxygen species detoxificators: superoxide dismutase, ascorbate peroxidase, glutathione reductase, guaiacol peroxidase and catalase are analyzed.

Benzene metabolites enhance reactive oxygen species generation in HL60 human leukemia cells

1996 ◽  
Vol 15 (5) ◽  
pp. 422-427 ◽  
Author(s):  
Y. Shen ◽  
H-M. Shen ◽  
C-Y. Shi ◽  
C-N. Ong
Keyword(s):  
Reactive Oxygen Species ◽  
Lipid Peroxidation ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Leukemia Cells ◽  
Ros Generation ◽  
Human Leukemia ◽  
Ros Production ◽  
Oxygen Species ◽  
Ros Formation

Benzene is myelotoxic and leukemogenic in humans. The mechanisms leading to these effects, however have not been fully elucidated. One of the underlying mechanisms is believed to be the oxidative damage caused by its metabolites. A comparative study was undertaken to examine the relationships between reactive oxygen species (ROS) production, lipid peroxidation and subse quent cytotoxicity induced by five major benzene meta bolites. The generation of ROS by benzene metabolites was demonstrated by the significant and dose-dependent increase of intracellular ROS formation in HL60 human promyelocytic leukemia cells in vitro. 1,4-Benzoquinone (BQ) was found to be the most potent metabolite in induction of ROS formation, followed by 1,2,4-benzene triol (BT) and to a lesser extent, phenol (PH) and trans, trans-muconaldehyde (MD). No significant effect was observed when the cells were treated with trans, trans-muconic acid (MA). The enhancement of ROS production by BQ was effectively inhibited by the addition of catalase, deferoxamine (DFO) and dimethyl sulfoxide (DMSO), but unchanged by superoxide dismutase (SOD), suggest that hydrogen peroxide (H2O2) and hydroxyl radicals (OH.) are the two major forms of ROS involved. The results also demonstrate that the ability of benzene metabolites in enhancing ROS generation is closely correlated to their capacity in causing lipid peroxidation and subsequent cytotoxicity. These findings together with earlier parallel observations on DNA damage suggest that ROS play an important role in the mechanism of carcinogenesis induced by benzene metabolites.

Роль оксида азота в реализации антиоксидантного эффекта неопиатного аналога лей-энкефалина в сердце новорожденных белых крыс

2019 ◽  
pp. 61-64
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Postnatal Period ◽  
Oxide System ◽  
No Synthase ◽  
Albino Rats ◽  
Oxygen Species ◽  
Control Parameters ◽  
Synthase Inhibitor

The eff ect of the non-opiate analog of leu-enkephalin (peptide NALE: Phe – D – Ala – Gly – Phe – Leu – Arg) on the reactive oxygen species generation in the heart of albino rats in the early postnatal period was studied. Peptide NALE was administered intraperitoneally in the dose of 100 μ/kg daily from 2 to 6 days of life. Reactive oxygen species generation was assessed by chemiluminescence in the heart homogenates of 7-day-old animals. Decreasing of reactive oxygen species generation nearly by 30 % and an increasing in antioxidant system activity by the 20-27 %, compared with the control parameters, were found. The antioxidant eff ect of peptide NALE is associated with the presence of the amino acid Arg in the structure of the peptide. An analogue of NALE peptide, devoid of Arg (peptide Phe – D – Ala – Gly – Phe – Leu – Gly), had a signifi cant lower antioxidant eff ect. The NO-synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) in the dose 50 mg/kg, administered with NALE peptide, reduced the severity of the NALE antioxidant eff ect. The results of the study suggest that the pronounced antioxidant eff ect of NALE peptide in the heart of albino rats, at least in part, is due to the interaction with the nitric oxide system.

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