scholarly journals Angiotensin II Sensitivity Is Associated With the Angiotensin II Type 1 Receptor A1166C Polymorphism in Essential Hypertensives on a High Sodium Diet

Hypertension ◽  
2000 ◽  
Vol 36 (3) ◽  
pp. 411-416 ◽  
Author(s):  
Wilko Spiering ◽  
Abraham A. Kroon ◽  
Monique M. J. J. Fuss-Lejeune ◽  
Mat J. A. P. Daemen ◽  
Peter W. de Leeuw
Keyword(s):  
Angiotensin Ii ◽  
High Sodium ◽  
Sodium Diet ◽  
A1166c Polymorphism ◽  
High Sodium Diet

The Influence of Sodium Intake on the Pressor Response to Angiotensin II in the Unanaesthetized Rat

1976 ◽  
Vol 50 (4) ◽  
pp. 285-291
Author(s):  
Barbara L. Slack ◽  
J. M. Ledingham
Keyword(s):  
Angiotensin Ii ◽  
Dose Response ◽  
Response Curve ◽  
Dose Response Curve ◽  
Response Curves ◽  
High Sodium ◽  
Sodium Diet ◽  
Low Sodium Diet ◽  
Low Sodium ◽  
High Sodium Diet

1. Dose—response curves for the pressor activity of angiotensin II have been determined in unanaesthetized rats receiving diets containing 2·5% (w/w) or 0·007% (w/w) sodium; the different diets were administered in various sequences. 2. In comparison with those from rats receiving a low sodium diet, the dose—response curves were displaced to the left on the high sodium diet, indicating a greater response to angiotensin, and this displacement persisted for a period of approximately 7 days after the diet was changed from high to low sodium. The dose—response curve subsequently shifted to the right when the low sodium diet was maintained for longer. 3. There was a negative correlation between the slope of the dose—response curve and the basal blood pressure in all groups; the correlation was significant in three out of the five different treatment groups. 4. Basal blood pressures were significantly raised in rats on the high sodium diet for 7 days. 5. A number of possible mechanisms have been considered to explain both the parallel shift of the dose—response curve and alteration in its slope. It is concluded that the observed findings are compatible with an action of sodium-loading on the sensitivity of the smooth muscle cell to angiotensin, on the resting of the renin—angiotensin system, on the rate of in-activation of angiotensin and on a change in initial length of the muscle fibre.

Comparison of systemic and direct intrarenal angiotensin II blockade on sodium excretion in rats

1995 ◽  
Vol 269 (1) ◽  
pp. F40-F46 ◽  
Author(s):  
Y. Peng ◽  
F. G. Knox
Keyword(s):  
Blood Pressure ◽  
Angiotensin Ii ◽  
Mean Arterial Pressure ◽  
Sodium Excretion ◽  
Systemic Effects ◽  
Ang Ii ◽  
High Sodium ◽  
Sodium Diet ◽  
High Sodium Diet ◽  
Interstitial Infusion

To dissociate the renal effects from the systemic effects of angiotensin II blockade, the present study was designed to determine the effects of systemic and renal interstitial infusion of the specific angiotensin II (ANG II) receptor antagonist, losartan, on blood pressure and sodium excretion in rats fed a low-, normal, or high-sodium diet. Fractional sodium excretion (FENa) and mean arterial pressure (MAP) were measured in rats before and during systemic infusion of losartan (10 mg/kg) or renal interstitial infusion of losartan (3 mg/kg) by means of a chronically implanted matrix. In rats fed a low- or normal sodium diet, systemic infusion of losartan markedly decreased MAP (delta -21 +/- 2, delta -10 +/- 2 mmHg, respectively; P < 0.05) with an accompanying fall in FENa (delta -0.10 +/- 0.05, delta -0.91 +/- 0.40%, respectively; P < 0.05). In contrast, preferential blockade of renal ANG II with renal interstitial losartan infusion resulted in an increase in FENa (delta 0.13 +/- 0.04, delta 0.95 +/- 0.45%, respectively; P < 0.05) and no significant change in MAP. In rats fed a high-sodium diet, both systemic and renal interstitial infusion of losartan increased FENa (delta 1.90 +/- 0.26, delta 1.40 +/- 0.56%, respectively; P < 0.05). Although systemic infusion of losartan decreased MAP (delta -4.4 +/- 0.6 mmHg, P < 0.05) in rats fed a high-sodium diet, the reduction in MAP was much less than that in rats fed a low- and normal sodium diet.(ABSTRACT TRUNCATED AT 250 WORDS)

Synergistic vascular effects of dietary sodium supplementation and angiotensin II administration

1997 ◽  
Vol 273 (3) ◽  
pp. H1275-H1282 ◽  
Author(s):  
B. Csiky ◽  
G. Simon
Keyword(s):  
Angiotensin Ii ◽  
Dietary Sodium ◽  
Ang Ii ◽  
Resistance Arteries ◽  
Vascular Effects ◽  
High Sodium ◽  
Sodium Diet ◽  
Term Administration ◽  
High Sodium Diet ◽  
Sodium Supplementation

The hypertensinogenic action of dietary sodium supplementation was investigated in angiotensin II (ANG II)-treated rats. We hypothesized that high-sodium diet would potentiate ANG II-induced vasoconstriction and hypertension, including the development of structural vascular changes, through synergistic action with ANG II in stimulating sympathetic activity and vascular growth. Mesenteric vasoconstrictor responses to ANG II, norepinephrine (NE), arginine vasopressin (AVP), and periarterial nerve stimulation were measured in Sprague-Dawley rats after 7-10 days of the following treatments: 200 ng.kg-1.min-1 ip ANG II (n = 12), 4% NaCl diet (n = 11), ANG II + 4% NaCl diet (n = 7), and 0.7% NaCl diet (controls) (n = 15). Additional rats received 50 ng.kg-1.min-1 sc ANG II (n = 8), 2% NaCl diet (n = 9), ANG II + 2% NaCl diet (n = 6), or 0.7% NaCl diet (controls) (n = 10) for 12 wk. Systolic blood pressure (SBP) values were measured weekly for 4 wk and then every other week for 8 wk. Then, the wall-to-lumen ratio (W/L) of mesenteric resistance arteries (< 150 microns OD) was measured after in situ perfusion-fixation. After 7-10 days of treatment, there were no significant changes in SBP in any of the groups. High-sodium diet increased vasoconstrictor responses to ANG II (P < 0.01) and nerve stimulation (P < 0.02), but not to NE or AVP, and in combination with ANG II treatment further potentiated vasoconstrictor responses to ANG II (synergism). After 12 wk of treatment, ANG II increased W/L of small resistance arteries by 11% (P < 0.05) without a significant rise in SBP. ANG II and 2% NaCl diet in combination raised SBP by 36 mmHg (P < 0.01) and increased small artery W/L by 28% (P < 0.001) compared with values obtained in control rats. To test the specificity of the interaction between ANG II and high-sodium diet, all the experiments were repeated during phenylephrine (PE, 10 micrograms.kg-1.min-1 sc) treatment of rats. PE by itself or in combination with high-sodium diet had no effect on the measured parameters. Thus short-term administration of high-sodium diet appears to potentiate vasoconstrictor responses to ANG II by facilitating sympathetic neurotransmission, and long-term administration of high-sodium diet raises SBP by potentiating the trophic vascular effects of ANG II. The interaction appears to be specific to ANG II and is occurring on the vascular level.

scholarly journals Enhanced angiotensin-converting enzyme activity and systemic reactivity to angiotensin II in normotensive rats exposed to a high-sodium diet

2014 ◽  
Vol 60 (2) ◽  
pp. 67-74 ◽  
Author(s):  
Sandra Crestani ◽  
Arquimedes Gasparotto Júnior ◽  
Maria C.A. Marques ◽  
Jennifer C. Sullivan ◽  
R. Clinton Webb ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Angiotensin Ii ◽  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme Activity ◽  
High Sodium ◽  
Sodium Diet ◽  
High Sodium Diet

Effect of dietary sodium intake on the pressor reactivity to angiotensin II in rats with experimental cirrhosis of the liver

1989 ◽  
Vol 67 (12) ◽  
pp. 1506-1511 ◽  
Author(s):  
L. M. Villamediana ◽  
Angel L. García-Villalón ◽  
Carlos Caramelo ◽  
José M. López-Novoa
Keyword(s):  
Angiotensin Ii ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Vascular Reactivity ◽  
Sodium Intake ◽  
Pressor Response ◽  
Experimental Cirrhosis ◽  
High Sodium ◽  
Sodium Diet ◽  
High Sodium Diet

The present experiments were designed to evaluate vascular reactivity to angiotensin II in rats with experimental cirrhosis of the liver (induced with CCl4 and phenobarbital) before ascites appearance. The systemic pressor response to angiotensin II in conscious animals and the contractile effect of angiotensin II in isolated femoral arteries were studied. In addition, the effect of high sodium intake on these parameters was also analyzed. Both renin and aldosterone plasma concentrations were similar in control and cirrhotic rats on the normal or on the high sodium diet. Basal mean arterial pressure was higher in control rats than in cirrhotic rats on the normal sodium (116 ± 4 vs. 101 ± 4 mmHg (1 mmHg = 133.3 Pa),p < 0.05) or on the high sodium diet (118 ± 7 vs. 98 ± 6 mmHg). No differences in plasma renin activity or plasma aldosterone were found between control and cirrhotic rats. Upon injection of angiotensin II, control rats show a dose-dependent increase in mean arterial pressure which is higher in high sodium than in normal sodium rats. Cirrhotic rats showed a lower hypertensive response to angiotensin II than their corresponding control rats. In addition, no difference between pressor responses to angiotensin II was observed when normal sodium and high sodium cirrhotic rats were compared. On application of angiotensin II, femoral arteries of control and cirrhotic rats exhibited a dose-dependent contraction. However, maximal contraction was higher in high sodium control rats (145 ± 12 mg) than in normal sodium control rats (99 ± 6 mg, p < 0.05). No significant differences between control and cirrhotic rats on either sodium diet were observed. In conclusion, cirrhotic, nonascitic rats showed an impaired pressor response to angiotensin II that is more marked after a high sodium diet. These differences are not due to changes in the contractility of peripheral arteries to angiotensin II.Key words: angiotensin II, liver cirrhosis, sodium intake, mean arterial pressure, vascular reactivity.

scholarly journals C allele of angiotensin II type 1 receptor gene A1166C polymorphism affects plasma adiponectin concentrations in healthy young Japanese women

2009 ◽  
Vol 32 (10) ◽  
pp. 901-905 ◽  
Author(s):  
Katsuko Miyanaga ◽  
Keisuke Fukuo ◽  
Hiroshi Akasaka ◽  
Tomohiro Katsuya ◽  
Rumi Fukada ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Receptor Gene ◽  
Japanese Women ◽  
Plasma Adiponectin ◽  
A1166c Polymorphism ◽  
Young Japanese Women

P1-93 Prenatal hyperglycemia alters kallikrein activity response to high sodium diet in adult rats

2007 ◽  
Vol 83 ◽  
pp. S108
Author(s):  
S.P. Salas ◽  
A. Giacaman ◽  
F.J. Guarda ◽  
J. Acosta ◽  
C.P. Vío
Keyword(s):  
Adult Rats ◽  
High Sodium ◽  
Sodium Diet ◽  
Activity Response ◽  
Kallikrein Activity ◽  
High Sodium Diet

scholarly journals Effects of High Sodium Diet on Dopaminergic Mechanism in Normal and Hypertensive Subjects

1988 ◽  
Vol 64 (11) ◽  
pp. 1157-1168
Author(s):  
Masaki TAKAHASHI ◽  
Yukio MIURA ◽  
Naoki SANO ◽  
Takashi OHZEKI ◽  
Takashi SUGAWARA ◽  
...  
Keyword(s):  
High Sodium ◽  
Sodium Diet ◽  
Dopaminergic Mechanism ◽  
High Sodium Diet
Sign in / Sign up

Export Citation Format

Share Document