scholarly journals Effects of Systemic Inhibition of Neuronal Nitric Oxide Synthase in Diabetic Rats

Hypertension ◽  
2000 ◽  
Vol 35 (2) ◽  
pp. 655-661 ◽  
Author(s):  
Radko Komers ◽  
Terry T. Oyama ◽  
Justin G. Chapman ◽  
Kristen M. Allison ◽  
Sharon Anderson
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Neuronal Nitric Oxide Synthase ◽  
Diabetic Rats ◽  
Oxide Synthase

Hyperalgesia and decreased neuronal nitric oxide synthase in diabetic rats

Neuroreport ◽  
1998 ◽  
Vol 9 (2) ◽  
pp. 177-177 ◽  
Author(s):  
Teiji Sasaki ◽  
Hitoshi Yasuda ◽  
Kengo Maeda ◽  
Ryuichi Kikkawa
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Neuronal Nitric Oxide Synthase ◽  
Diabetic Rats ◽  
Oxide Synthase

Insulin restores neuronal nitric oxide synthase expression in streptozotocin-induced diabetic rats

Life Sciences ◽  
2000 ◽  
Vol 68 (6) ◽  
pp. 625-634 ◽  
Author(s):  
Wen-Jen Yu ◽  
Show-Wen Juang ◽  
Wan-Tai Chin ◽  
Tzong-Cherng Chi ◽  
Chih-Jen Chang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Neuronal Nitric Oxide Synthase ◽  
Diabetic Rats ◽  
Oxide Synthase

scholarly journals Diabetes-Related Induction of the Heme Oxygenase System and Enhanced Colocalization of Heme Oxygenase 1 and 2 with Neuronal Nitric Oxide Synthase in Myenteric Neurons of Different Intestinal Segments

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Lalitha Chandrakumar ◽  
Mária Bagyánszki ◽  
Zita Szalai ◽  
Diána Mezei ◽  
Nikolett Bódi
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Heme Oxygenase ◽  
Defense Mechanisms ◽  
Neuronal Nitric Oxide Synthase ◽  
Diabetic Rats ◽  
Heme Oxygenase 1 ◽  
Double Labelling ◽  
Myenteric Neurons ◽  
Oxide Synthase

Increase in hyperglycaemia-induced oxidative stress and decreased effectiveness of endogenous defense mechanisms plays an essential role in the initiation of diabetes-related neuropathy. We demonstrated that nitrergic myenteric neurons display different susceptibilities to diabetic damage in different gut segments. Therefore, we aim to reveal the gut segment-specific differences in the expression of heme oxygenase (HO) isoforms and the colocalization of these antioxidants with neuronal nitric oxide synthase (nNOS) in myenteric neurons. After ten weeks, samples from the duodenum, ileum, and colon of control and streptozotocin-induced diabetic rats were processed for double-labelling fluorescent immunohistochemistry and ELISA. The number of both HO-immunoreactive and nNOS/HO-immunoreactive myenteric neurons was the lowest in the ileal and the highest in the colonic ganglia of controls; it increased the most extensively in the ileum and was also elevated in the colon of diabetics. Although the total number of nitrergic neurons decreased in all segments, the proportion of nNOS-immunoreactive neurons colocalizing with HOs was enhanced robustly in the ileum and colon of diabetics. We presume that those nitrergic neurons which do not colocalize with HOs are the most seriously affected by diabetic damage. Therefore, the regional induction of the HO system is strongly correlated with diabetes-related region-specific nitrergic neuropathy.

Effects of long-term inhibition of neuronal nitric oxide synthase (NOS1) in uninephrectomized diabetic rats

Nitric Oxide ◽  
2004 ◽  
Vol 11 (2) ◽  
pp. 147-155 ◽  
Author(s):  
Radko Komers ◽  
Jessie N. Lindsley ◽  
Terry T. Oyama ◽  
Sharon Anderson
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Neuronal Nitric Oxide Synthase ◽  
Diabetic Rats ◽  
Oxide Synthase

Increase in neuronal nitric oxide synthase content of the gastroduodenal tract of diabetic rats

2003 ◽  
Vol 60 (6) ◽  
pp. 1172-1179 ◽  
Author(s):  
E. Adeghate ◽  
B. al-Ramadi ◽  
A. M. Saleh ◽  
C. Vijayarasathy ◽  
A. S. Ponery ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Neuronal Nitric Oxide Synthase ◽  
Diabetic Rats ◽  
Oxide Synthase
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