scholarly journals Gene Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 and Type 2 in the Kidneys of Insulin-Dependent Diabetic Rats

Hypertension ◽  
1998 ◽  
Vol 31 (3) ◽  
pp. 885-889 ◽  
Author(s):  
Yan-Jun Liu ◽  
Yuichi Nakagawa ◽  
Takehiko Ohzeki
Keyword(s):  
Gene Expression ◽  
Hydroxysteroid Dehydrogenase ◽  
Diabetic Rats ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

scholarly journals The Role of Placental 11-Beta Hydroxysteroid Dehydrogenase Type 1 and Type 2 Methylation on Gene Expression and Infant Birth Weight1

2015 ◽  
Vol 92 (6) ◽  
Author(s):  
Benjamin B. Green ◽  
David A. Armstrong ◽  
Corina Lesseur ◽  
Alison G. Paquette ◽  
Dylan J. Guerin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hydroxysteroid Dehydrogenase ◽  
Infant Birth

Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats

2008 ◽  
Vol 441 (2) ◽  
pp. 201-204 ◽  
Author(s):  
Liang-Ming Lee ◽  
Cheng Kuei Chang ◽  
Kai-Chun Cheng ◽  
Dai-Huang Kou ◽  
I-Min Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Muscarinic Receptor ◽  
Receptor Gene ◽  
Diabetic Rats ◽  
M2 Muscarinic Receptor ◽  
Receptor Gene Expression ◽  
Type 2 Diabetic

Complications Following Operatively Treated Ankle Fractures in Insulin- and Non–Insulin-Dependent Diabetic Patients

2017 ◽  
Vol 11 (3) ◽  
pp. 206-216 ◽  
Author(s):  
Kevin P. Haddix ◽  
R. Carter Clement ◽  
Joshua N. Tennant ◽  
Robert F. Ostrum
Keyword(s):  
Subgroup Analysis ◽  
Ankle Fractures ◽  
Diabetic Patients ◽  
Posttraumatic Arthritis ◽  
Complication Rates ◽  
Health Care Database ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Background: Diabetics with ankle fractures experience more complications than the general population, but it is unclear whether complications differ between type 1 and 2 diabetics and between insulin- and non–insulin-dependent diabetics. This study aims to determine if there is a difference in postoperative complication rates between these groups. Methods: An administrative health care database from a large commercial insurer was queried to identify operatively treated ankle fractures in patients with type 1 (T1D), type 2 (T2D), type 2 insulin-dependent (T2ID), and type 2 non–insulin-dependent (T2NID) diabetes. Postoperative complications were identified to include postoperative stiffness, posttraumatic arthritis, amputation, implant removal, and infection. Subgroup analysis was performed to control for comorbidities. Results: A total of 20 703 closed and 2873 open operatively treated ankle fractures were identified. Patients with T1D experienced higher rates of amputation, postoperative infection, and total complications than patients with T2D (P < .05). Patients with T2ID experienced higher rates of amputation, infection, and total complications than those with T2NID (P < .0001). Subgroup analysis controlling for comorbidities showed a higher total complication rate for T1D compared with T2D in closed ankle fractures (P < .02) and for T2ID compared with T2NID in both open and closed ankle fractures (P < .0001). Conclusions: Patients with T1D and T2ID have higher complication rates than patients with T2D and T2NID, respectively. Foot and ankle surgeons should be cautioned not to classify diabetics as one cohort and should use these findings to stratify risk among this patient population. Levels of Evidence: Level III: Diagnostic

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