Association of Variants in Critical Core Promoter Element of Angiotensinogen Gene With Increased Risk of Essential Hypertension in Japanese

Hypertension ◽  
1997 ◽  
Vol 30 (3) ◽  
pp. 321-325 ◽  
Author(s):  
Noriyuki Sato ◽  
Tomohiro Katsuya ◽  
Hiromi Rakugi ◽  
Seiju Takami ◽  
Yukiko Nakata ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Core Promoter ◽  
Promoter Element ◽  
Core Promoter Element ◽  
Angiotensinogen Gene ◽  
Increased Risk

scholarly journals DTIE, a novel core promoter element that directs start site selection in TATA-less genes

2015 ◽  
Vol 44 (3) ◽  
pp. 1080-1094 ◽  
Author(s):  
Nadav Marbach-Bar ◽  
Anat Bahat ◽  
Shaked Ashkenazi ◽  
Michal Golan-Mashiach ◽  
Ora Haimov ◽  
...  
Keyword(s):  
Site Selection ◽  
Core Promoter ◽  
Start Site ◽  
Promoter Element ◽  
Core Promoter Element

The DPE, a Conserved Downstream Core Promoter Element That Is Functionally Analogous to the TATA Box

1998 ◽  
Vol 63 (0) ◽  
pp. 75-82 ◽  
Author(s):  
T.W. BURKE ◽  
P.J. WILLY ◽  
A.K. KUTACH ◽  
J.E.F. BUTLER ◽  
J.T. KADONAGA
Keyword(s):  
Core Promoter ◽  
Tata Box ◽  
Promoter Element ◽  
Core Promoter Element

scholarly journals Identification of a novel p53 promoter element involved in genotoxic stress-inducible p53 gene expression.

1995 ◽  
Vol 15 (8) ◽  
pp. 4489-4496 ◽  
Author(s):  
X Sun ◽  
H Shimizu ◽  
K Yamamoto
Keyword(s):  
Stress Response ◽  
Anticancer Drugs ◽  
Promoter Activity ◽  
Core Promoter ◽  
Genotoxic Stress ◽  
Promoter Element ◽  
Promoter Activation ◽  
Nf Kappa B ◽  
Core Promoter Element ◽  
Genotoxic Agents

p53 is recruited in response to DNA-damaging genotoxic stress and plays an important role in maintaining the integrity of the genome. We show that exposure of cells to various genotoxic agents, including anticancer drugs such as mitomycin and 5-fluorouracil, results in an increase in p53 mRNA levels and in p53 promoter activation, indicating that the p53 genotoxic stress response is partly regulated at the transcriptional level. The results of the p53 promoter analysis show that a novel p53 promoter element, termed a p53 core promoter element (from -70 to -46), is essential for basal p53 promoter activity and promoter activation induced by genotoxic agents such as anticancer drugs and UV. Although a kappa B motif partially overlaps with this element and those genotoxic agents activate NF-kappa B, it does not play a major role in p53 genotoxic stress response: NF-kappa B p65 expression did not induce significant p53 promoter activation, and NF-kappa B inhibitors (N-acetyl cysteine and I kappa B alpha) did not inhibit genotoxic stress-inducible p53 promoter activation. Finally, we characterized nuclear factors, the binding of which to the p53 core promoter element is essential for basal p53 promoter activity and p53 promoter activation induced by genotoxic agents.

The Initiator Motif is Preferentially Used as the Core Promoter Element in Ionizing Radiation-Responsive Genes

2006 ◽  
Vol 166 (5) ◽  
pp. 810-813 ◽  
Author(s):  
Jianyu Wu ◽  
Kazuhiro Daino ◽  
Sachiko Ichimura ◽  
Mitsuru Nenoi
Keyword(s):  
Ionizing Radiation ◽  
Core Promoter ◽  
Promoter Element ◽  
Core Promoter Element ◽  
The Core

scholarly journals Characterization of sINR, a strict version of the Initiator core promoter element

2009 ◽  
Vol 37 (13) ◽  
pp. 4234-4246 ◽  
Author(s):  
Ganit Yarden ◽  
Rofa Elfakess ◽  
Kfir Gazit ◽  
Rivka Dikstein
Keyword(s):  
Core Promoter ◽  
Promoter Element ◽  
Core Promoter Element
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